TY  - JOUR
AB  - serovar Dublin is adapted to cattle but is able to infect humans with high invasiveness. An acute inflammatory response at the intestine helps to prevent dissemination to systemic sites. Flagella contribute to this response by providing motility and FliC-mediated signaling through pattern recognition receptors. In a previous work, we reported a high frequency (11 out of 25) of Dublin isolates lacking flagella in a collection obtained from humans and cattle. The aflagellate strains were impaired in their proinflammatory properties and The aim of this work was to elucidate the underlying cause of the absence of flagella in Dublin isolates. We report here that class 3 flagellar genes are repressed in the human aflagellate isolates, due to impaired secretion of FliA anti-sigma factor FlgM. This phenotype is due to an in-frame 42-nucleotide deletion in the gene, which codes for a protein located in the flagellar basal body. The deletion is predicted to produce a protein lacking amino...
AU  - Sasías, Sebastián
AU  - Martínez-Sanguiné, Adriana
AU  - Betancor, Laura
AU  - Martínez, Arací
AU  - D'Alessandro, Bruno
AU  - Iriarte, Andrés
AU  - Chabalgoity, José A
AU  - Yim, Lucía
DA  - 201801
DO  - 10.1128/IAI.00517-17
KW  - Flie ; Salmonella ; Flagella ; Proinflammatory Capacity ; Serovar Dublin ; Bacterial Proteins -- Genetics ; Flagella -- Genetics ; Salmonella Enterica -- Genetics ; Sequence Deletion -- Genetics
LA  - eng
PY  - 201801
SN  - 1098-5522
SN  - 0019-9567
T2  - Infection and immunity
TI  - A Naturally Occurring Deletion in FliE from Salmonella enterica Serovar Dublin Results in an Aflagellate Phenotype and Defective Proinflammatory Properties
Y2  - 2021-02-25T15:29:50+01:00
ER  -