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    Eupartoium makinoi suppresses lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression

    Ahn, Sang-Il, Lim, Se Jin, Gu, Gyo-Jeong, Kim, Ji-Soo, Paek, Ji Hun, Kim, Songmun, Lim, Soon Sung, Youn, Hyung-Sun
    Food and agricultural immunology, 04 July 2015, Vol.26(4), pp.496-503 [Peer Reviewed Journal]
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    Title: Eupartoium makinoi suppresses lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression
    Author: Ahn, Sang-Il; Lim, Se Jin; Gu, Gyo-Jeong; Kim, Ji-Soo; Paek, Ji Hun; Kim, Songmun; Lim, Soon Sung; Youn, Hyung-Sun
    Subject: Eupatorium Makinoi ; Lipopolysaccharide ; Nuclear Factor-Κb ; Cyclooxygenase-2 ; Inducible Nitric Oxide Synthase ; Biology
    Description: Inflammation is involved in numerous diseases including cancer. Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play important roles in the development of certain inflammatory diseases. Eupatorium makinoi, which belongs to a family of Asteraceae plants, is used medicinally in East Asia. We investigated the effects of an ethanol extract of E. makinoi (E) on nuclear factor-kappa B (NF-κB) activation and the expression of iNOS and COX-2 with lipopolysaccharide (TLR4 agonist) in murine macrophages. E suppressed NF-κB activation and iNOS and COX-2 expression induced by LPS. These results suggest that E may regulate TLR4 signalling pathways and this may be a useful strategy for anti-inflammatory therapies.
    Is part of: Food and agricultural immunology, 04 July 2015, Vol.26(4), pp.496-503
    Identifier: 0954-0105 (ISSN); 1465-3443 (E-ISSN); 10.1080/09540105.2014.968768 (DOI)

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    Transcription factors Rv0081 and Rv3334 connect the early and the enduring hypoxic response of Mycobacterium tuberculosis

    Sun, Xian, Zhang, Lu, Jiang, Jun, Ng, Mark, Cui, Zhenling, Mai, Juntao, Ahn, Sang Kyun, Liu, Jingqian, Zhang, Jinyu, Liu, Jun, Li, Yao
    Virulence, 31 December 2018, Vol.9(1), pp.1468-1482 [Peer Reviewed Journal]

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    Aster yomena suppresses LPS-induced cyclooxygenase-2 and inducible nitric oxide synthase expression

    Kim, Ji-Soo, Kim, Ah-Yeon, Shin, Hyeon-Myeong, Ahn, Sang-Il, Shim, Hyun-Jin, Nam, Kung-Woo, Hwang, Kyung-A, Youn, Hyung-Sun
    Food and agricultural immunology, 04 March 2017, Vol.28(2), pp.202-210 [Peer Reviewed Journal]
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    Title: Aster yomena suppresses LPS-induced cyclooxygenase-2 and inducible nitric oxide synthase expression
    Author: Kim, Ji-Soo; Kim, Ah-Yeon; Shin, Hyeon-Myeong; Ahn, Sang-Il; Shim, Hyun-Jin; Nam, Kung-Woo; Hwang, Kyung-A; Youn, Hyung-Sun
    Subject: Aster Yomena ; Inflammation ; Nuclear Factor-Κb ; Cyclooxygenase-2 ; Inducible Nitric Oxide Synthase ; Biology
    Description: Inflammation is a pathological process that is known to be involved in numerous diseases. Microbial infection or tissue injury activates inflammatory responses, resulting in the induction of proinflammatory proteins including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Aster yomena is used in traditional Korean remedies to treat cough, asthma, and insect bites. Here, we investigated the effects of A. yomena extract (EAY) on the expression of COX-2 and iNOS induced by LPS. EAY inhibited NF-κB activation and IκBα degradation induced by LPS. EAY suppressed LPS-induced COX-2 and iNOS expression which are the target genes regulated through NF-κB activation in macrophages. EAY also suppressed LPS-induced nitrite production. These results suggest that EAY has the potential to be developed as a potent anti-inflammatory drug.
    Is part of: Food and agricultural immunology, 04 March 2017, Vol.28(2), pp.202-210
    Identifier: 0954-0105 (ISSN); 1465-3443 (E-ISSN); 10.1080/09540105.2016.1251395 (DOI)

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    Eupatorium makinoi suppresses toll-like receptor signaling pathways

    Ahn, Sang-Il, Kim, Ji-Soo, Hong, Chae-Yeon, Gu, Gyo-Jeong, Shin, Hyeon-Myeong, Paek, Ji Hun, Kim, Songmun, Lim, Soon Sung, Youn, Hyung-Sun
    Food and agricultural immunology, 03 March 2016, Vol.27(2), pp.242-250 [Peer Reviewed Journal]
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    Title: Eupatorium makinoi suppresses toll-like receptor signaling pathways
    Author: Ahn, Sang-Il; Kim, Ji-Soo; Hong, Chae-Yeon; Gu, Gyo-Jeong; Shin, Hyeon-Myeong; Paek, Ji Hun; Kim, Songmun; Lim, Soon Sung; Youn, Hyung-Sun
    Subject: Toll-Like Receptor ; Myd88 ; Trif ; Nf-Κb ; Irf3 ; Biology
    Description: Toll-like receptors (TLRs) recognize microbial molecules that are widely presented by pathogens and initiate the innate immune system. TLR signaling is divided into two different signaling pathways, the myeloid differential factor 88 (MyD88)- and Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF)-dependent pathways. Eupatorium makinoi, a plant species in Asteraceae, is used for medicinal purposes in China, Korea, and Japan. Through our previous research, we found that an ethanol extract of E. makinoi (E) suppresses inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. In this study, we investigated the effect of E on TLRs signaling pathways. E suppresses NF-κB activation and iNOS and COX-2 expressions induced by TLR2 or TLR4 agonists. Also, E suppresses the activation of interferon (IFNs) regulatory factor 3 (IRF3) induced by TLR3 or TLR4 agonists. All results indicate that E suppresses myeloid differentiation...
    Is part of: Food and agricultural immunology, 03 March 2016, Vol.27(2), pp.242-250
    Identifier: 0954-0105 (ISSN); 1465-3443 (E-ISSN); 10.1080/09540105.2015.1086315 (DOI)

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    Tiled stereo display system for immersive telemeeting

    Kim, Ig-Jae, Ahn, Sang Chul, Kim, Hyoung-Gon
    Journal of Information Display, 01 January 2007, Vol.8(4), pp.27-31 [Peer Reviewed Journal]
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    Title: Tiled stereo display system for immersive telemeeting
    Author: Kim, Ig-Jae; Ahn, Sang Chul; Kim, Hyoung-Gon
    Subject: Tiled Display ; Telemeeting ; Real-Time Warping ; Gpu ; Engineering
    Description: In this paper, we present an efficient tiled stereo display system for tangible meeting. For tangible meeting, it is important to provide immersive display with high resolution image to cover up the field of view and provide to the local user the same environment as that of remote site. To achieve these, a high resolution image needs to be transmitted for reconstruction of remote world, and it should be displayed using a tiled display. However, it is hard to transmit high resolution image in real time due to the limit of network bandwidth, and so we receive multiple images and reconstruct a remote world with received images in advance. Then, we update only a specific area where remote user exists by receiving low resolution image in realtime. We synthesize the transmitted image to the existing environmental map of remote world and display it as a stereo image. For this, we developed a new system which supports GPU based real time warping and blending, automatic feature extraction...
    Is part of: Journal of Information Display, 01 January 2007, Vol.8(4), pp.27-31
    Identifier: 1598-0316 (ISSN); 2158-1606 (E-ISSN); 10.1080/15980316.2007.9652043 (DOI)