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    Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment

    Han, Sang, Kim, Seung, Ahn, Sang, Han, Kwang-Hyub
    PLoS One, Jan 2013, Vol.8(1), p.e52720 [Peer Reviewed Journal]
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    Title: Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment
    Author: Han, Sang; Kim, Seung; Ahn, Sang; Han, Kwang-Hyub
    Subject: South Korea ; Liver ; Human Immunodeficiency Virus–HIV ; Proteinase Inhibitors ; Confidence Intervals ; Stiffness ; Correlation Analysis ; Antiretroviral Agents ; Patients ; Physicians ; Proteinase Inhibitors ; Regression Analysis ; Regression Analysis ; Acquired Immune Deficiency Syndrome–AIDS ; Liver Diseases ; Exposure ; Antiretroviral Drugs ; Liver
    Description: Background and Aims Liver stiffness measurement (LSM) using transient elastography (Fibroscan®) can identify individuals with potential underlying liver disease. We evaluated the prevalence of abnormal LSM values as assessed using LSM and its predictors in HIV-infected asymptomatic patients receiving combined antiretroviral treatment (cART) without HBV/HCV coinfection. Methods We prospectively recruited 93 patients who had consistently been undergoing cART for more than 12 months at Severance Hospital in Seoul, Republic of Korea, from June to December 2010. LSM values >5.3 kPa were defined as abnormal. Results Thirty-nine (41.9%) had abnormal LSM values. On multivariate correlation analysis, the cumulative duration of boosted and unboosted protease inhibitors (PIs) were the independent factors which showed a negative and positive correlation to LSM values, respectively (β = –0.234, P = 0.023 and β = 0.430, P
    Is part of: PLoS One, Jan 2013, Vol.8(1), p.e52720
    Identifier: 19326203 (E-ISSN); 10.1371/journal.pone.0052720 (DOI)

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    Abnormal liver stiffness assessed using transient elastography (Fibroscan®) in HIV-infected patients without HBV/HCV coinfection receiving combined antiretroviral treatment

    Han, Sang Hoon, Kim, Seung Up, Kim, Chang Oh, Jeong, Su Jin, Park, Jun Yong, Choi, Jun Yong, Kim, Do Young, Ahn, Sang Hoon, Song, Young Goo, Han, Kwang-Hyub, Kim, June Myung
    PloS one, 2013, Vol.8(1), pp.e52720 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Abnormal liver stiffness assessed using transient elastography (Fibroscan®) in HIV-infected patients without HBV/HCV coinfection receiving combined antiretroviral treatment
    Author: Han, Sang Hoon; Kim, Seung Up; Kim, Chang Oh; Jeong, Su Jin; Park, Jun Yong; Choi, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Song, Young Goo; Han, Kwang-Hyub; Kim, June Myung
    Subject: Elasticity Imaging Techniques -- Methods ; HIV Infections -- Complications ; Liver -- Pathology ; Liver Cirrhosis -- Complications
    Description: Liver stiffness measurement (LSM) using transient elastography (Fibroscan®) can identify individuals with potential underlying liver disease. We evaluated the prevalence of abnormal LSM values as assessed using LSM and its predictors in HIV-infected asymptomatic patients receiving combined antiretroviral treatment (cART) without HBV/HCV coinfection. We prospectively recruited 93 patients who had consistently been undergoing cART for more than 12 months at Severance Hospital in Seoul, Republic of Korea, from June to December 2010. LSM values >5.3 kPa were defined as abnormal. Thirty-nine (41.9%) had abnormal LSM values. On multivariate correlation analysis, the cumulative duration of boosted and unboosted protease inhibitors (PIs) were the independent factors which showed a negative and positive correlation to LSM values, respectively (β = -0.234, P = 0.023 and β = 0.430, P
    Is part of: PloS one, 2013, Vol.8(1), pp.e52720
    Identifier: 1932-6203 (E-ISSN); 23300987 Version (PMID); 10.1371/journal.pone.0052720 (DOI)

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    Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment

    Han, Sang Hoon, Kim, Seung Up, Kim, Chang Oh, Jeong, Su Jin, Park, Jun Yong, Choi, Jun Yong, Kim, Do Young, Ahn, Sang Hoon, Song, Young Goo, Han, Kwang-Hyub, Kim, June Myung
    PLoS ONE, 2013, Vol.8(1) [Peer Reviewed Journal]
    U.S. National Library of Medicine (NIH/NLM)
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    Title: Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment
    Author: Han, Sang Hoon; Kim, Seung Up; Kim, Chang Oh; Jeong, Su Jin; Park, Jun Yong; Choi, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Song, Young Goo; Han, Kwang-Hyub; Kim, June Myung
    Contributor: Villa, Erica (editor)
    Subject: Research Article ; Medicine
    Description: Background and Aims Liver stiffness measurement (LSM) using transient elastography (Fibroscan®) can identify individuals with potential underlying liver disease. We evaluated the prevalence of abnormal LSM values as assessed using LSM and its predictors in HIV-infected asymptomatic patients receiving combined antiretroviral treatment (cART) without HBV/HCV coinfection. Methods We prospectively recruited 93 patients who had consistently been undergoing cART for more than 12 months at Severance Hospital in Seoul, Republic of Korea, from June to December 2010. LSM values >5.3 kPa were defined as abnormal. Results Thirty-nine (41.9%) had abnormal LSM values. On multivariate correlation analysis, the cumulative duration of boosted and unboosted protease inhibitors (PIs) were the independent factors which showed a negative and positive correlation to LSM values, respectively ( β  = –0.234, P  = 0.023 and β  = 0.430, P
    Is part of: PLoS ONE, 2013, Vol.8(1)
    Identifier: 1932-6203 (E-ISSN); 10.1371/journal.pone.0052720 (DOI); 3536776 (PMCID); 23300987 (PMID)

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    Abnormal liver stiffness assessed using transient elastography (Fibroscan®) in HIV-infected patients without HBV/HCV coinfection receiving combined antiretroviral treatment

    Sang Hoon Han, Seung Up Kim, Chang Oh Kim, Su Jin Jeong, Jun Yong Park, Jun Yong Choi, Do Young Kim, Sang Hoon Ahn, Young Goo Song, Kwang-Hyub Han, June Myung Kim
    PloS one, 01 January 2013, Vol.8(1), p.e52720 [Peer Reviewed Journal]
    Directory of Open Access Journals (DOAJ)
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    Title: Abnormal liver stiffness assessed using transient elastography (Fibroscan®) in HIV-infected patients without HBV/HCV coinfection receiving combined antiretroviral treatment
    Author: Sang Hoon Han; Seung Up Kim; Chang Oh Kim; Su Jin Jeong; Jun Yong Park; Jun Yong Choi; Do Young Kim; Sang Hoon Ahn; Young Goo Song; Kwang-Hyub Han; June Myung Kim
    Subject: Sciences (General)
    Description: Liver stiffness measurement (LSM) using transient elastography (Fibroscan®) can identify individuals with potential underlying liver disease. We evaluated the prevalence of abnormal LSM values as assessed using LSM and its predictors in HIV-infected asymptomatic patients receiving combined antiretroviral treatment (cART) without HBV/HCV coinfection.We prospectively recruited 93 patients who had consistently been undergoing cART for more than 12 months at Severance Hospital in Seoul, Republic of Korea, from June to December 2010. LSM values 5.3 kPa were defined as abnormal.Thirty-nine (41.9%) had abnormal LSM values. On multivariate correlation analysis, the cumulative duration of boosted and unboosted protease inhibitors (PIs) were the independent factors which showed a negative and positive correlation to LSM values, respectively (β = -0.234, P = 0.023 and β = 0.430, P0.001). In multivariate logistic regression analysis, the cumulative exposure duration of boosted-PIs...
    Is part of: PloS one, 01 January 2013, Vol.8(1), p.e52720
    Identifier: 1932-6203 (E-ISSN); 10.1371/journal.pone.0052720 (DOI)