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Language: German

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Suppression of Toll-Like Receptor 4 Dimerization by 1-5-Methoxy-2-(2-nitrovinyl)phenylpyrrolidine
Ahn, Sang-Il, Kim, Ji-Soo, Gu, Gyo-Jeong, Shin, Hyeon-Myeong, Kim, Ah-Yeon, Shim, Hyun-Jin, Kim, Yeon Joo, Koh, Kwang Oh, Mang, Joo Yang, Kim, Dae Young, Youn, Hyung-Sun
Archiv der Pharmazie, October 2016, Vol.349(10), pp.785-790 [Peer Reviewed Journal]
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Title: Suppression of Toll-Like Receptor 4 Dimerization by 1-5-Methoxy-2-(2-nitrovinyl)phenylpyrrolidine
Author: Ahn, Sang-Il; Kim, Ji-Soo; Gu, Gyo-Jeong; Shin, Hyeon-Myeong; Kim, Ah-Yeon; Shim, Hyun-Jin; Kim, Yeon Joo; Koh, Kwang Oh; Mang, Joo Yang; Kim, Dae Young; Youn, Hyung-Sun
Subject: 1-[5-Methoxy-2-(2-Nitrovinyl)Phenyl]Pyrrolidine ; Inflammation ; Lipopolysaccharide ; Nf-Κb ; Toll-Like Receptor ; Nitro Compounds -- Pharmacology ; Protein Multimerization -- Drug Effects ; Pyrrolidines -- Pharmacology ; Toll-Like Receptor 4 -- Metabolism
Description: Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS) and triggers the activation of myeloid differention factor 88 (MyD88) and the Toll/interleukin-1 receptor domain-containing adapter, inducing interferon-β (TRIF)-dependent major downstream signaling pathways. To evaluate the therapeutic potential of 1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine (MNP), previously synthesized in our laboratory, its effect on signal transduction via the TLR signaling pathways was examined. Here, we investigated whether MNP modulates the TLR4 signaling pathways and which anti-inflammatory target in TLR4 signaling is regulated by MNP. MNP inhibited the activation of nuclear factor-κB (NF-κB) induced by LPS (TLR4 agonist), and it also inhibited the expression of cyclooxygenase-2 and inducible nitric oxide synthase. MNP inhibited LPS-induced NF-κB activation by targeting TLR4 dimerization in addition to IKKβ. These results suggest that MNP can modulate the TLR4 signaling pathway at the receptor...
Is part of: Archiv der Pharmazie, October 2016, Vol.349(10), pp.785-790
Identifier: 1521-4184 (E-ISSN); 27515124 Version (PMID); 10.1002/ardp.201600159 (DOI)

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Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis
Kim, Ja Kyung, Park, Young Nyun, Kim, Jin Seok, Park, Mi-Suk, Paik, Yong Han, Seok, Jae-Yeon, Chung, Yong Eun, Kim, Hyun Ok, Kim, Kyung Sik, Ahn, Sang Hoon, Kim, Do Young, Kim, Myeong-Jin, Lee, Kwan Sik, Chon, Chae Yoon, Kim, Soo Jeong, Terai, Shuji, Sakaida, Isao, Han, Kwang-Hyub
Cell transplantation, 2010, Vol.19(10), pp.1237-46 [Peer Reviewed Journal]

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Suppression of Toll-Like Receptor 4 Dimerization by 1-5-Methoxy-2-(2-nitrovinyl)phenylpyrrolidine

Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis