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    HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression

    Moon, Sung-Min, Kim, Soo-A, Yoon, Jung-Hoon, Ahn, Sang-Gun
    The Journal of biological chemistry, 12 October 2012, Vol.287(42), pp.35678-35688 [Peer Reviewed Journal]
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    Title: HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression
    Author: Moon, Sung-Min; Kim, Soo-A; Yoon, Jung-Hoon; Ahn, Sang-Gun
    Subject: Gene Expression Regulation, Neoplastic ; Response Elements ; Carcinoma, Squamous Cell -- Metabolism ; Head and Neck Neoplasms -- Metabolism ; Homeodomain Proteins -- Metabolism ; Proto-Oncogene Proteins C-Bcl-2 -- Biosynthesis
    Description: Homeobox C6 (HOXC6) genes belong to the homeoprotein family of transcription factors, which play an important role in morphogenesis and cellular differentiation during embryonic development. The aim of this study was to explore the role of HOXC6 in the regulation of Bcl-2 in human head and neck squamous cell carcinoma (HNSCC). The HOXC6 and Bcl-2 gene were identified as being overexpressed in HNSCC tissue and cell lines. Transfection assays demonstrated that HOXC6 increased the levels of Bcl-2 mRNA and protein. A luciferase reporter assay suggested that HOXC6 induced activity of the Bcl-2 promoter. A series of Bcl-2 promoter deletion mutants were examined and the minimal HOXC6-responsive region was identified to be in the TAAT motif (-420 bp) of the Bcl-2 promoter. Interestingly, the inhibition of HOXC6 using siRNA led to the repression of Bcl-2 expression and induced caspase-3-dependent apoptosis; overexpression of HOXC6 in HNSCC cells increased the resistance to paclitaxel-induced apoptosis....
    Is part of: The Journal of biological chemistry, 12 October 2012, Vol.287(42), pp.35678-35688
    Identifier: 1083-351X (E-ISSN); 22896703 Version (PMID); 10.1074/jbc.M112.361675 (DOI)

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    Genome Context as a Predictive Tool for Identifying Regulatory Targets of the TetR Family Transcriptional Regulators (Finding Target Genes for TetR Family Regulators)

    Ahn, Sang Kyun, Cuthbertson, Leslie, Nodwell, Justin R
    2012, Vol.7(11), p.e50562 [Peer Reviewed Journal]

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    Combined Adenovirus-Mediated Artificial microRNAs Targeting mfgl2, mFas, and mTNFR1 Protect against Fulminant Hepatic Failure in Mice (Virus-Mediated miRNA Treatment of Hepatic Failure)

    Xi, Dong, Wang, Ming, Ye, Huali, Luo, Xiaoping, Ning, Qin
    2013, Vol.8(11), p.e82330 [Peer Reviewed Journal]

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    Static Numbers to Dynamic Statistics: Designing a Policy-Friendly Social Policy Indicator Framework

    Ahn, Sang-Hoon, Choi, Young, Kim, Young-Mi
    Social Indicators Research, 2012, Vol.108(3), pp.387-400 [Peer Reviewed Journal]

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    Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway

    Hong, Elim, Santhakumar, Kirankumar, Akitake, Courtney A, Ahn, Sang Jung, Thisse, Christine, Thisse, Bernard, Wyart, Claire, Mangin, Jean-Marie, Halpern, Marnie E
    Proceedings of the National Academy of Sciences of the United States of America, 24 December 2013, Vol.110(52), pp.21171-6 [Peer Reviewed Journal]

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    The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA

    Choe, Junho, Ahn, Sang Ho, Kim, Yoon Ki
    Nucleic acids research, August 2014, Vol.42(14), pp.9334-49 [Peer Reviewed Journal]

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    Dynamics of the Liver Stiffness Value Using Transient Elastography during the Perioperative Period in Patients with Valvular Heart Disease

    Chon, Young Eun, Kim, Seung Up, Park, Jun Yong, Kim, Do Young, Ahn, Sang Hoon, Han, Kwang-Hyub, Chon, Chae Yoon, Lee, Sak
    PLoS ONE, 2014, Vol.9(3) [Peer Reviewed Journal]

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    Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment

    Han, Sang Hoon, Kim, Seung Up, Kim, Chang Oh, Jeong, Su Jin, Park, Jun Yong, Choi, Jun Yong, Kim, Do Young, Ahn, Sang Hoon, Song, Young Goo, Han, Kwang-Hyub, Kim, June Myung
    PLoS ONE, 2013, Vol.8(1) [Peer Reviewed Journal]

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    Association between IL28B Polymorphisms and Spontaneous Clearance of Hepatitis B Virus Infection

    Kim, Seung Up, Song, Ki Jun, Chang, Hye Young, Shin, Eui-Cheol, Park, Jun Yong, Kim, Do Young, Han, Kwang-Hyub, Chon, Chae Yoon, Ahn, Sang Hoon
    PLoS ONE, 2013, Vol.8(7) [Peer Reviewed Journal]

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    The Hepatitis B Virus X Protein Inhibits Thymine DNA Glycosylase Initiated Base Excision Repair (Inhibition of BER by the HBV Protein X)

    van de Klundert, Maarten A. A, van Hemert, Formijn J, Zaaijer, Hans L, Kootstra, Neeltje A
    2012, Vol.7(11), p.e48940 [Peer Reviewed Journal]

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