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    HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression

    Moon, Sung-Min, Kim, Soo-A, Yoon, Jung-Hoon, Ahn, Sang-Gun
    The Journal of biological chemistry, 12 October 2012, Vol.287(42), pp.35678-35688 [Peer Reviewed Journal]
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    Title: HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression
    Author: Moon, Sung-Min; Kim, Soo-A; Yoon, Jung-Hoon; Ahn, Sang-Gun
    Subject: Gene Expression Regulation, Neoplastic ; Response Elements ; Carcinoma, Squamous Cell -- Metabolism ; Head and Neck Neoplasms -- Metabolism ; Homeodomain Proteins -- Metabolism ; Proto-Oncogene Proteins C-Bcl-2 -- Biosynthesis
    Description: Homeobox C6 (HOXC6) genes belong to the homeoprotein family of transcription factors, which play an important role in morphogenesis and cellular differentiation during embryonic development. The aim of this study was to explore the role of HOXC6 in the regulation of Bcl-2 in human head and neck squamous cell carcinoma (HNSCC). The HOXC6 and Bcl-2 gene were identified as being overexpressed in HNSCC tissue and cell lines. Transfection assays demonstrated that HOXC6 increased the levels of Bcl-2 mRNA and protein. A luciferase reporter assay suggested that HOXC6 induced activity of the Bcl-2 promoter. A series of Bcl-2 promoter deletion mutants were examined and the minimal HOXC6-responsive region was identified to be in the TAAT motif (-420 bp) of the Bcl-2 promoter. Interestingly, the inhibition of HOXC6 using siRNA led to the repression of Bcl-2 expression and induced caspase-3-dependent apoptosis; overexpression of HOXC6 in HNSCC cells increased the resistance to paclitaxel-induced apoptosis....
    Is part of: The Journal of biological chemistry, 12 October 2012, Vol.287(42), pp.35678-35688
    Identifier: 1083-351X (E-ISSN); 22896703 Version (PMID); 10.1074/jbc.M112.361675 (DOI)

    • Several versions

    The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA

    Choe, Junho, Ahn, Sang Ho, Kim, Yoon Ki
    Nucleic acids research, August 2014, Vol.42(14), pp.9334-49 [Peer Reviewed Journal]

    • Several versions

    Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment

    Han, Sang Hoon, Kim, Seung Up, Kim, Chang Oh, Jeong, Su Jin, Park, Jun Yong, Choi, Jun Yong, Kim, Do Young, Ahn, Sang Hoon, Song, Young Goo, Han, Kwang-Hyub, Kim, June Myung
    PLoS ONE, 2013, Vol.8(1) [Peer Reviewed Journal]

    • Several versions

    Association between IL28B Polymorphisms and Spontaneous Clearance of Hepatitis B Virus Infection

    Kim, Seung Up, Song, Ki Jun, Chang, Hye Young, Shin, Eui-Cheol, Park, Jun Yong, Kim, Do Young, Han, Kwang-Hyub, Chon, Chae Yoon, Ahn, Sang Hoon
    PLoS ONE, 2013, Vol.8(7) [Peer Reviewed Journal]

    • Several versions

    The Hepatitis B Virus X Protein Inhibits Thymine DNA Glycosylase Initiated Base Excision Repair (Inhibition of BER by the HBV Protein X)

    van de Klundert, Maarten A. A, van Hemert, Formijn J, Zaaijer, Hans L, Kootstra, Neeltje A
    2012, Vol.7(11), p.e48940 [Peer Reviewed Journal]

    • Several versions

    Serum γ-glutamyl Transferase Levels, Insulin Resistance and Liver Fibrosis in Patients with Chronic Liver Diseases (γ-GT, IR and Fibrosis)

    Petta, Salvatore, Macaluso, Fabio Salvatore, Barcellona, Maria Rosa, Cammà, Calogero, Cabibi, Daniela, Di Marco, Vito, Craxì, Antonio
    2012, Vol.7(12), p.e51165 [Peer Reviewed Journal]

    • Several versions

    A Novel Model to Predict Esophageal Varices in Patients with Compensated Cirrhosis Using Acoustic Radiation Force Impulse Elastography

    Park, Yehyun, Kim, Seung Up, Park, Soo Young, Kim, Beom Kyung, Park, Jun Yong, Kim, Do Young, Ahn, Sang Hoon, Tak, Won Young, Kweon, Young Oh, Han, Kwang-Hyub
    PLoS ONE, 2015, Vol.10(3) [Peer Reviewed Journal]

    • Several versions

    Performance of Transient Elastography for the Staging of Liver Fibrosis in Patients with Chronic Hepatitis B: A Meta-Analysis (A Meta-Analysis on Performance of TE)

    Chon, Young Eun, Choi, Eun Hee, Song, Ki Jun, Park, Jun Yong, Kim, Do Young, Han, Kwang-Hyub, Chon, Chae Yoon, Ahn, Sang Hoon, Kim, Seung Up
    2012, Vol.7(9), p.e44930 [Peer Reviewed Journal]

    • Several versions

    Casein Kinase II Inhibitor Enhances Production of Infectious Genotype 1a Hepatitis C Virus (H77S)

    Kim, Seungtaek, Jin, Bora, Choi, Sung Hoon, Han, Kwang-Hyub, Ahn, Sang Hoon
    PLoS ONE, 2014, Vol.9(12) [Peer Reviewed Journal]

    • Several versions

    Prospective Validation of FibroTest in Comparison with Liver Stiffness for Predicting Liver Fibrosis in Asian Subjects with Chronic Hepatitis B (FibroTest and Fibroscan in Asian CHB Subjects)

    Kim, Beom Kyung, Kim, Seung Up, Kim, Hyon Suk, Park, Jun Yong, Ahn, Sang Hoon, Chon, Chae Yoon, Cho, In Rae, Joh, Dong-Hoo, Park, Young Nyun, Han, Kwang-Hyub, Kim, Do Young
    PLoS ONE, 2012, Vol.7(4), p.e35825 [Peer Reviewed Journal]