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    Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells

    Aleksandrov, Dmitry A, Zagryagskaya, Anna N, Pushkareva, Marina A, Bachschmid, Markus, Peters-Golden, Marc, Werz, Oliver, Steinhilber, Dieter, Sud'Ina, Galina F
    The FEBS journal, February 2006, Vol.273(3), pp.548-57 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells
    Author: Aleksandrov, Dmitry A; Zagryagskaya, Anna N; Pushkareva, Marina A; Bachschmid, Markus; Peters-Golden, Marc; Werz, Oliver; Steinhilber, Dieter; Sud'Ina, Galina F
    Subject: Lipoxygenase Inhibitors ; Arachidonate 5-Lipoxygenase -- Metabolism ; Cholesterol -- Analogs & Derivatives ; Neutrophils -- Metabolism
    Description: 5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes (LTs), biological mediators of host defense reactions and of inflammatory diseases. While the role of membrane binding in the regulation of 5-LO activity is well established, the effects of lipids on cellular activity when added to the medium has not been characterized. Here, we show such a novel function of the most abundant sulfated sterol in human blood, cholesterol sulfate (CS), to suppress LT production in human polymorphonuclear leukocytes (PMNL) and Mono Mac6 cells. We synthesized another anionic lipid, cholesterol phosphate, which demonstrated a similar capacity in suppression of LT synthesis in PMNL. Cholesteryl acetate was without effect. Cholesterol increased the effect of CS on 5-LO product synthesis. CS and cholesterol also inhibited arachidonic acid (AA) release from PMNL. Addition of exogenous AA increased the threshold concentration of CS required to inhibit LT synthesis. The effect of cholesterol...
    Is part of: The FEBS journal, February 2006, Vol.273(3), pp.548-57
    Identifier: 1742-464X (ISSN); 16420478 Version (PMID)

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    Underlying Event measurements in pp collisions at $ \sqrt {s} = 0.9 $ and 7 TeV with the ALICE experiment at the LHC

    Abelev, Betty, Quintana, Arian, Adamova, Dagmar, Adare, Andrew, Aggarwal, Madan, Rinella, Gianluca, Agocs, Andras, Agostinelli, Andrea, Salazar, Saul, Ahammed, Zubayer, Ahmad, Nazeer, Ahmad, Arshad, Ahn, Sang, Akindinov, Alexander, Aleksandrov, Dmitry, Alessandro, Bruno, Molina, Jose, Alici, Andrea, Alkin, Anton, Avina, Erick, Alt, Torsten, Altini, Valerio, Altinpinar, Sedat, Altsybeev, Igor, Andrei, Cristian, Andronic, Anton, Anguelov, Venelin, Anson, Christopher, Anticic, Tome, Antinori, Federico, Antonioli, Pietro, Aphecetche, Laurent, Appelshauser, Harald, Arbor, Nicolas, Arcelli, Silvia, Arend, Andreas, Armesto, Nestor, Arnaldi, Roberta, Aronsson, Tomas, Arsene, Ionut, Arslandok, Mesut, Asryan, Andzhey, Augustinus, Andre, Averbeck, Ralf, Awes, Terry, Aysto, Juha, Azmi, Mohd, Bach, Matthias, Badala, Angela, Baek, Yong, Bailhache, Raphaelle, Bala, Renu, Ferroli, Rinaldo, Baldisseri, Alberto, Baldit, Alain, Pedrosa, Fernando, Ban, Jaroslav, Baral, Rama, Barbera, Roberto, Barile, Francesco, Barnafoldi, Gergely, Barnby, Lee, Barret, Valerie, Bartke, Jerzy, Basile, Maurizio, Bastid, Nicole, Bathen, Bastian, Batigne, Guillaume, Batyunya, Boris, Baumann, Christoph, Bearden, Ian, Beck, Hans, Belikov, Iouri, Bellini, Francesca, Bellwied, Rene, Belmont-Moreno, Ernesto, Beole, Stefania, Berceanu, Ionela, Bercuci, Alexandru, Berdnikov, Yaroslav, Berenyi, Daniel, Bergmann, Cyrano, Berzano, Dario, Betev, Latchezar, Bhasin, Anju, Bhati, Ashok, Bianchi, Nicola, Bianchi, Livio, Bianchin, Chiara, Bielcik, Jaroslav, Bielcikova, Jana, Bilandzic, Ante, Blanco, F., Blanco, Francesco, Blau, Dmitry, Blume, Christoph, Boccioli, Marco, Bock, Nicolas, Bogdanov, Alexey, Boggild, Hans, Bogolyubsky, Mikhail, Boldizsar, Laszlo, Bombara, Marek, Book, Julian, Borel, Herve, Borissov, Alexander, Bortolin, Claudio, Bose, Suvendu, Bossu, Francesco, Botje, Michiel, Bottger, Stefan, Boyer, Bruno, Braun-Munzinger, Peter, Bregant, Marco, Breitner, Timo, Broz, Michal, Brun, Rene, Bruna, Elena, Bruno, Giuseppe, Budnikov, Dmitry, Buesching, Henner, Bufalino, Stefania, Bugaiev, Kyrylo, Busch, Oliver, Buthelezi, Edith, Caffarri, Davide, Cai, Xu, Caines, Helen, Villar, Ernesto, Camerini, Paolo, Roman, Veronica, Romeo, Giovanni, Carena, Francesco, Carena, Wisla, Filho, Nelson, Carminati, Federico, Montoya, Camilo, Diaz, Amaya, Caselle, Michele, Castellanos, Javier, Hernandez, Juan, Casula, Ester, Catanescu, Vasile, Cavicchioli, Costanza, Cepila, Jan, Cerello, Piergiorgio, Chang, Beomsu, Chapeland, Sylvain, Charvet, Jean-Luc, Chattopadhyay, Sukalyan, Chattopadhyay, Subhasis, Cherney, Michael, Cheshkov, Cvetan, Cheynis, Brigitte, Chiavassa, Emilio, Barroso, Vasco, Chinellato, David, Chochula, Peter, Chojnacki, Marek, Christakoglou, Panagiotis, Christensen, Christian, Christiansen, Peter, Chujo, Tatsuya, Chung, Suh-Urk, Cicalo, Corrado, Cifarelli, Luisa, Cindolo, Federico, Cleymans, Jean, Coccetti, Fabrizio, Coffin, Jean-Pierre, Colamaria, Fabio, Colella, Domenico, Balbastre, Gustavo, Valle, Zaida, Constantin, Paul, Contin, Giacomo, Contreras, Jesus, Cormier, Thomas, Morales, Yasser, Cortese, Pietro, Maldonado, Ismael, Cosentino, Mauro, Costa, Filippo, Cotallo, Manuel, Crescio, Elisabetta, Crochet, Philippe, Alaniz, Emilia, Cuautle, Eleazar, Cunqueiro, Leticia, Dainese, Andrea, Dalsgaard, Hans, Danu, Andrea, Das, Indranil, Das, Kushal, Das, Debasish, Dash, Ajay, Dash, Sadhana, De, Sudipan, Azevedo Moregula, Andrea, Barros, Gabriel, Caro, Annalisa, Cataldo, Giacinto, Cuveland, Jan, Falco, Alessandro, Gruttola, Daniele, Delagrange, Hugues, Castillo Sanchez, Eduardo, Deloff, Andrzej, Demanov, Vyacheslav, Marco, Nora, Denes, Ervin, Pasquale, Salvatore, Deppman, Airton, D’Erasmo, Ginevra, Rooij, Raoul, Bari, Domenico, Dietel, Thomas, Giglio, Carmelo, Liberto, Sergio, Mauro, Antonio, Nezza, Pasquale, Divia, Roberto, Djuvsland, Oeystein, Dobrin, Alexandru, Dobrowolski, Tadeusz, Dominguez, Isabel, Donigus, Benjamin, Dordic, Olja, Driga, Olga, Dubey, Anand, Ducroux, Laurent, Dupieux, Pascal, Majumdar, Mihir, Majumdar, A.K., Elia, Domenico, Emschermann, David, Engel, Heiko, Erdal, Hege, Espagnon, Bruno, Estienne, Magali, Esumi, Shinichi, Evans, David, Eyyubova, Gyulnara, Fabris, Daniela, Faivre, Julien, Falchieri, Davide, Fantoni, Alessandra, Fasel, Markus, Fearick, Roger, Fedunov, Anatoly, Fehlker, Dominik, Feldkamp, Linus, Felea, Daniel, Feofilov, Grigory, Tellez, Arturo, Ferretti, Alessandro, Ferretti, Roberta, Figiel, Jan, Figueredo, Marcel, Filchagin, Sergey, Fini, Rosa, Finogeev, Dmitry, Fionda, Fiorella, Fiore, Enrichetta, Floris, Michele, Foertsch, Siegfried, Foka, Panagiota, Fokin, Sergey, Fragiacomo, Enrico, Fragkiadakis, Michail, Frankenfeld, Ulrich, Fuchs, Ulrich, Furget, Christophe, Girard, Mario, Gaardhoje, Jens, Gagliardi, Martino, Gago, Alberto, Gallio, Mauro, Gangadharan, Dhevan, Ganoti, Paraskevi, Garabatos, Jose, Garcia-Solis, Edmundo, Garishvili, Irakli, Gerhard, Jochen, Germain, Marie, Geuna, Claudio, Gheata, Andrei, Gheata, Mihaela, Ghidini, Bruno, Ghosh, Premomoy, Gianotti, Paola, Girard, Martin, Giubellino, Paolo, Gladysz-Dziadus, Ewa, Glassel, Peter, Gomez, Ramon, Ferreiro, Elena, Gonzalez-Trueba, Laura, Gonzalez-Zamora, Pedro, Gorbunov, Sergey, Goswami, Ankita, Gotovac, Sven, Grabski, Varlen, Graczykowski, Lukasz, Grajcarek, Robert, Grelli, Alessandro, Grigoras, Costin, Grigoras, Alina, Grigoriev, Vladislav, Grigoryan, Ara, Grigoryan, Smbat, Grinyov, Boris, Grion, Nevio, Gros, Philippe, Grosse-Oetringhaus, Jan, Grossiord, Jean-Yves, Grosso, Raffaele, Guber, Fedor, Guernane, Rachid, Gutierrez, Cesar, Guerzoni, Barbara, Guilbaud, Maxime, Gulbrandsen, Kristjan, Gunji, Taku, Gupta, Anik, Gupta, Ramni, Gutbrod, Hans, Haaland, Oystein, Hadjidakis, Cynthia, Haiduc, Maria, Hamagaki, Hideki, Hamar, Gergoe, Han, Byounghee, Hanratty, Luke, Hansen, Alexander, Harmanova, Zuzana, Harris, John, Hartig, Matthias, Hasegan, Dumitru, Hatzifotiadou, Despoina, Hayrapetyan, Arsen, Heckel, Stefan, Heide, Markus, Helstrup, Haavard, Herghelegiu, Andrei, Corral, Gerardo, Herrmann, Norbert, Hetland, Kristin, Hicks, Bernard, Hille, Per, Hippolyte, Boris, Horaguchi, Takuma, Hori, Yasuto, Hristov, Peter, Hrivnacova, Ivana, Huang, Meidana, Huber, Sebastian, Humanic, Thomas, Hwang, Dae, Ichou, Raphaelle, Ilkaev, Radiy, Ilkiv, Iryna, Inaba, Motoi, Incani, Elisa, Innocenti, Pier, Innocenti, Gian, Ippolitov, Mikhail, Irfan, Muhammad, Ivan, Cristian, Ivanov, Marian, Ivanov, Vladimir, Ivanov, Andrey, Ivanytskyi, Oleksii, Jacholkowski, Adam, Jacobs, Peter, Jancurova, Lucia, Jang, Haeng, Jangal, Swensy, Janik, Rudolf, Janik, Malgorzata, Jayarathna, Sandun, Jena, Satyajit, Bustamante, Raul, Jirden, Lennart, Jones, Peter, Jung, Won, Jung, Hyung, Jusko, Anton, Kaidalov, Alexei, Kakoyan, Vanik, Kalcher, Sebastian, Kalinak, Peter, Kalisky, Matus, Kalliokoski, Tuomo, Kalweit, Alexander, Kanaki, Kalliopi, Kang, Ju, Kaplin, Vladimir, Uysal, Ayben, Karavichev, Oleg, Karavicheva, Tatiana, Karpechev, Evgeny, Kazantsev, Andrey, Kebschull, Udo, Keidel, Ralf, Khan, Palash, Khan, Mohisin, Khan, Shuaib, Khanzadeev, Alexei, Kharlov, Yury, Kileng, Bjarte, Kim, Jonghyun, Kim, Dong, Kim, Do, Kim, Jin, Kim, Minwoo, Kim, Seon, Kim, Se, Kim, Beomkyu, Kim, Taesoo, Kirsch, Stefan, Kisel, Ivan, Kiselev, Sergey, Kisiel, Adam, Klay, Jennifer, Klein, Jochen, Klein-Bosing, Christian, Kliemant, Michael, Kluge, Alexander, Knichel, Michael, Koch, Kathrin, Kohler, Markus, Kolojvari, Anatoly, Kondratiev, Valery, Kondratyeva, Natalia, Konevskih, Artem, Korneev, Andrey, Don, Chamath, Kour, Ravjeet, Kowalski, Marek, Kox, Serge, Meethaleveedu, Greeshma, Kral, Jiri, Kralik, Ivan, Kramer, Frederick, Kraus, Ingrid, Krawutschke, Tobias, Kretz, Matthias, Krivda, Marian, Krizek, Filip, Krus, Miroslav, Kryshen, Evgeny, Krzewicki, Mikolaj, Kucheriaev, Yury, Kuhn, Christian, Kuijer, Paul, Kurashvili, Podist, Kurepin, A.B., Kurepin, A., Kuryakin, Alexey, Kushpil, Svetlana, Kushpil, Vasily, Kvaerno, Henning, Kweon, Min, Kwon, Youngil, Guevara, Pedro, Lakomov, Igor, Langoy, Rune, Lara, Camilo, Lardeux, Antoine, Rocca, Paola, Lazzeroni, Cristina, Lea, Ramona, Bornec, Yves, Lee, Sung, Lee, Ki, Lefevre, Frederic, Lehnert, Joerg, Leistam, Lars, Lenhardt, Matthieu, Lenti, Vito, Leon, Hermes, Monzon, Ildefonso, Vargas, Hermes, Levai, Peter, Li, Xiaomei, Lien, Jorgen, Lietava, Roman, Lindal, Svein, Lindenstruth, Volker, Lippmann, Christian, Lisa, Michael, Liu, Lijiao, Loenne, Per-Ivar, Loggins, Vera, Loginov, Vitaly, Lohn, Stefan, Lohner, Daniel, Loizides, Constantinos, Loo, Kai, Lopez, Xavier, Torres, Ernesto, Lovhoiden, Gunnar, Lu, Xianguo, Luettig, Philipp, Lunardon, Marcello, Luo, Jiebin, Luparello, Grazia, Luquin, Lionel, Luzzi, Cinzia, Ma, Rongrong, Ma, Ke, Madagodahettige-Don, Dilan, Maevskaya, Alla, Mager, Magnus, Mahapatra, Durga, Maire, Antonin, Malaev, Mikhail, Cervantes, Ivonne, Malinina, Ludmila, Mal’Kevich, Dmitry, Malzacher, Peter, Mamonov, Alexander, Manceau, Loic, Mangotra, Lalit, Manko, Vladislav, Manso, Franck, Manzari, Vito, Mao, Yaxian, Marchisone, Massimiliano, Mares, Jiri, Margagliotti, Giacomo, Margotti, Anselmo, Marin, Ana, Markert, Christina, Martashvili, Irakli, Martinengo, Paolo, Martinez, Mario, Davalos, Arnulfo, Garcia, Gines, Martynov, Yevgen, Mas, Alexis, Masciocchi, Silvia, Masera, Massimo, Masoni, Alberto, Massacrier, Laure, Mastromarco, Mario, Mastroserio, Annalisa, Matthews, Zoe, Matyja, Adam, Mayani, Daniel, Mayer, Christoph, Mazer, Joel, Mazzoni, Aless...
    Journal of High Energy Physics, 2012, Vol.2012(7), pp.1-43 [Peer Reviewed Journal]
    Springer Science & Business Media B.V.