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    Proteomic analysis of Proteus mirabilis outer membrane proteins reveals differential expression in vivo vs. in vitro conditions

    D'Alessandro, Bruno, Lery, Leticia M. S, Von Krüger, Wanda M. A, Lima, Analía, Piccini, Claudia, Zunino, Pablo
    FEMS Immunology & Medical Microbiology, 2011, Vol. 63(2), pp.174-182 [Peer Reviewed Journal]

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    An iron-regulated outer-membrane protein of Proteus mirabilis is a haem receptor that plays an important role in urinary tract infection and in in vivo growth

    Lima, Analía, Zunino, Pablo, D'Alessandro, Bruno, Piccini, Claudia
    Journal of medical microbiology, December 2007, Vol.56(Pt 12), pp.1600-1607 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: An iron-regulated outer-membrane protein of Proteus mirabilis is a haem receptor that plays an important role in urinary tract infection and in in vivo growth
    Author: Lima, Analía; Zunino, Pablo; D'Alessandro, Bruno; Piccini, Claudia
    Subject: Bacterial Outer Membrane Proteins -- Metabolism ; Iron -- Pharmacology ; Proteus Mirabilis -- Metabolism ; Receptors, Cell Surface -- Metabolism ; Urinary Tract Infections -- Physiopathology
    Description: Proteus mirabilis, a common cause of urinary tract infections, expresses iron-regulated outer-membrane proteins (OMPs) in response to iron restriction. It has been suggested that a 64 kDa OMP is involved in haemoprotein uptake and that this might have a role in pathogenesis. In order to confirm this hypothesis, this study generated a P. mirabilis mutant strain (P7) that did not express the 64 kDa OMP, by insertion of the TnphoA transposon. The nucleotide sequence of the interrupted gene revealed that it corresponded to a haemin receptor precursor. Moreover, in vitro growth assays showed that the mutant was unable to grow using haemoglobin and haemin as unique iron sources. The authors also carried out in vivo growth and infectivity assays and demonstrated that P7 was not able to survive in an in vivo model and was less efficient than wild-type strain Pr 6515 in colonizing the urinary tract. These results confirmed that the P. mirabilis 64 kDa iron-regulated OMP is a haem receptor that has...
    Is part of: Journal of medical microbiology, December 2007, Vol.56(Pt 12), pp.1600-1607
    Identifier: 0022-2615 (ISSN); 18033826 Version (PMID); 10.1099/jmm.0.47320-0 (DOI)