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    Steroidal Saponins from the Mesocarp of the Fruits of Raphia farinifera (Arecaceae) and their Cytotoxic Activity

    Tapondjou, Léon A, Siems, Kristina J, Böttger, Stefan, Melzig, Matthias F
    Natural product communications, November 2015, Vol.10(11), pp.1941-4 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Steroidal Saponins from the Mesocarp of the Fruits of Raphia farinifera (Arecaceae) and their Cytotoxic Activity
    Author: Tapondjou, Léon A; Siems, Kristina J; Böttger, Stefan; Melzig, Matthias F
    Subject: Arecaceae -- Chemistry ; Cytotoxins -- Pharmacology ; Fruit -- Chemistry ; Plant Extracts -- Pharmacology ; Saponins -- Pharmacology ; Steroids -- Pharmacology
    Description: Eight steroidal saponins (1-8), including one previously unreported derivative (1), have been isolated from the mesocarp of Raphia farinifera fruits by combined column chromatography and RP-HPLC methods. They were characterized by spectroscopic (1D and 2D NMR experiments) and spectrometric (ESIMS) methods, as well as by comparison of their spectral data with those of reported compounds in the literature. All the isolated compounds were tested for cytotoxicity against urinary bladder carcinoma cells (ECV-304). Our results revealed that, for a high cytotoxicity, a sugar chain of at least three sugar moieties attached to C-3 of the steroidal saponin is necessary.
    Is part of: Natural product communications, November 2015, Vol.10(11), pp.1941-4
    Identifier: 1934-578X (ISSN); 26749832 Version (PMID)

    • Several versions

    LED-Absorption-QEPAS Sensor for Biogas Plants

    Köhring, Michael, Böttger, Stefan, Willer, Ulrike, Schade, Wolfgang
    Sensors, 2015, Vol.15(5), pp.12092-12102 [Peer Reviewed Journal]

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    Title: Untersuchungen zur synergistischen Zytotoxizität zwischen Saponinen und Ribosomen inaktivierenden Proteinen Typ I : Research on the synergistic cytotoxicity between saponins and ribosome inactivating proteins type I
    Author: Böttger, Stefan
    Contributor: Prof. Dr. Matthias F. Melzig
    Publisher: Berlin: Freie Universität Berlin Universitätsbibliothek
    Date: 2013
    Subject: 572 Biochemistry ; 572 Biochemie ; Ddc:572 ; Saponin ; Lectin ; Ribosome Inactivating Protein ; Rip ; Cholesterol ; Membrane ; Saponinum Album ; Caryophyllaceae ; Agrostemma Githago
    Description: In the present work eight plant extracts of Caryophyllaceae and 76 substances (saponins and aglyca) were analyzed for their cytotoxicity and their ability to synergistically enhance the cytotoxicity of ribosome-inactivating proteins type I (RIP I). Therefore a cell-based model using ECV-304-cells and the naturally little cytotoxic RIP-I saporin, considered as a standard-RIP-I, was developed. Referring these results to the structures of the substances, structure-activity-relationships (SAR) were established. This allowed identifying structural features that enable and amplify the cytotoxicity of RIP I. It also allowed detecting structural features that inhibit the synergistic enhancement of cytotoxicity of RIP I. Two potent saponins, SA1641 and SA1657, which synergistically enhance the cytotoxicity of RIP I were isolated from Saponinum album, a formerly commercial saponin mixture of the company Merck. The structure of SA1657 was elucidated as new substance. Four saponins were isolated from an extract from the seeds of Agrostemma githago L. Although three of these substances, Gypsophilasaponin 1 – 3, were already known from other species, they were described for this species for the first time. The structure of Agrostemmasaponin 3 was elucidated as new substance and synergistically enhanced the cytotoxicity of RIP I. A further amplification of the synergistic enhancement of the cytotoxicity of the RIP I Agrostin that is also present in the species, compared to the synergistic enhancement of the cytotoxicity of the RIP I Saporin from Saponaria officinalis L. by the saponins isolated from Agrostemma githago L. was not detected. Experiments on the membrane activity of saponins revealed a linear correlation between the membrane toxicity of saponins and their characteristic to lower the surface tension of aqueous solutions. Furthermore a cell-based model using radiolabeled cholesterol was developed to analyze the influence of saponins on the cholesterol content of cell membranes. Results from the model showed, that membrane active saponins lowered the cholesterol content of cell membranes. These saponins also hindered the uptake of free cholesterol into the cell membrane resulting in a decreased cholesterol content compared to a control. Saponins that are not membrane active did not influence the cholesterol content of cells in the same range of concentration. An influence of the membrane active saponin SA1641 on the cholesterol content of endosomes was not detectable.

    • Several versions

    Underlying Event measurements in pp collisions at and 7 TeV with the ALICE experiment at the LHC

    Quintana, Arian, Rinella, Gianluca, Agostinelli, Andrea, Nazeer, Ahmad, Ahmad, Arshad, Ahn, Sang, Bruno, Alessandro, Alici, Andrea, Alt, Torsten, Anson, Christopher, Tome, Anticic, Aphecetche, Laurent, Arcelli, Silvia, Arend, Andreas, Arnaldi, Roberta, Aronsson, Tomas, Arsene, Ionut, Averbeck, Ralf, Awes, Terry, Bach
    Journal of High Energy Physics, Jul 2012, Vol.2012(7) [Peer Reviewed Journal]

    • Several versions

    Underlying Event measurements in pp collisions at $ \sqrt {s} = 0.9 $ and 7 TeV with the ALICE experiment at the LHC

    Abelev, Betty, Quintana, Arian, Adamova, Dagmar, Adare, Andrew, Aggarwal, Madan, Rinella, Gianluca, Agocs, Andras, Agostinelli, Andrea, Salazar, Saul, Ahammed, Zubayer, Ahmad, Nazeer, Ahmad, Arshad, Ahn, Sang, Akindinov, Alexander, Aleksandrov, Dmitry, Alessandro, Bruno, Molina, Jose, Alici, Andrea, Alkin, Anton, Avina, Erick, Alt, Torsten, Altini, Valerio, Altinpinar, Sedat, Altsybeev, Igor, Andrei, Cristian, Andronic, Anton, Anguelov, Venelin, Anson, Christopher, Anticic, Tome, Antinori, Federico, Antonioli, Pietro, Aphecetche, Laurent, Appelshauser, Harald, Arbor, Nicolas, Arcelli, Silvia, Arend, Andreas, Armesto, Nestor, Arnaldi, Roberta, Aronsson, Tomas, Arsene, Ionut, Arslandok, Mesut, Asryan, Andzhey, Augustinus, Andre, Averbeck, Ralf, Awes, Terry, Aysto, Juha, Azmi, Mohd, Bach, Matthias, Badala, Angela, Baek, Yong, Bailhache, Raphaelle, Bala, Renu, Ferroli, Rinaldo, Baldisseri, Alberto, Baldit, Alain, Pedrosa, Fernando, Ban, Jaroslav, Baral, Rama, Barbera, Roberto, Barile, Francesco, Barnafoldi, Gergely, Barnby, Lee, Barret, Valerie, Bartke, Jerzy, Basile, Maurizio, Bastid, Nicole, Bathen, Bastian, Batigne, Guillaume, Batyunya, Boris, Baumann, Christoph, Bearden, Ian, Beck, Hans, Belikov, Iouri, Bellini, Francesca, Bellwied, Rene, Belmont-Moreno, Ernesto, Beole, Stefania, Berceanu, Ionela, Bercuci, Alexandru, Berdnikov, Yaroslav, Berenyi, Daniel, Bergmann, Cyrano, Berzano, Dario, Betev, Latchezar, Bhasin, Anju, Bhati, Ashok, Bianchi, Nicola, Bianchi, Livio, Bianchin, Chiara, Bielcik, Jaroslav, Bielcikova, Jana, Bilandzic, Ante, Blanco, F., Blanco, Francesco, Blau, Dmitry, Blume, Christoph, Boccioli, Marco, Bock, Nicolas, Bogdanov, Alexey, Boggild, Hans, Bogolyubsky, Mikhail, Boldizsar, Laszlo, Bombara, Marek, Book, Julian, Borel, Herve, Borissov, Alexander, Bortolin, Claudio, Bose, Suvendu, Bossu, Francesco, Botje, Michiel, Bottger, Stefan, Boyer, Bruno, Braun-Munzinger, Peter, Bregant, Marco, Breitner, Timo, Broz, Michal, Brun, Rene, Bruna, Elena, Bruno, Giuseppe, Budnikov, Dmitry, Buesching, Henner, Bufalino, Stefania, Bugaiev, Kyrylo, Busch, Oliver, Buthelezi, Edith, Caffarri, Davide, Cai, Xu, Caines, Helen, Villar, Ernesto, Camerini, Paolo, Roman, Veronica, Romeo, Giovanni, Carena, Francesco, Carena, Wisla, Filho, Nelson, Carminati, Federico, Montoya, Camilo, Diaz, Amaya, Caselle, Michele, Castellanos, Javier, Hernandez, Juan, Casula, Ester, Catanescu, Vasile, Cavicchioli, Costanza, Cepila, Jan, Cerello, Piergiorgio, Chang, Beomsu, Chapeland, Sylvain, Charvet, Jean-Luc, Chattopadhyay, Sukalyan, Chattopadhyay, Subhasis, Cherney, Michael, Cheshkov, Cvetan, Cheynis, Brigitte, Chiavassa, Emilio, Barroso, Vasco, Chinellato, David, Chochula, Peter, Chojnacki, Marek, Christakoglou, Panagiotis, Christensen, Christian, Christiansen, Peter, Chujo, Tatsuya, Chung, Suh-Urk, Cicalo, Corrado, Cifarelli, Luisa, Cindolo, Federico, Cleymans, Jean, Coccetti, Fabrizio, Coffin, Jean-Pierre, Colamaria, Fabio, Colella, Domenico, Balbastre, Gustavo, Valle, Zaida, Constantin, Paul, Contin, Giacomo, Contreras, Jesus, Cormier, Thomas, Morales, Yasser, Cortese, Pietro, Maldonado, Ismael, Cosentino, Mauro, Costa, Filippo, Cotallo, Manuel, Crescio, Elisabetta, Crochet, Philippe, Alaniz, Emilia, Cuautle, Eleazar, Cunqueiro, Leticia, Dainese, Andrea, Dalsgaard, Hans, Danu, Andrea, Das, Indranil, Das, Kushal, Das, Debasish, Dash, Ajay, Dash, Sadhana, De, Sudipan, Azevedo Moregula, Andrea, Barros, Gabriel, Caro, Annalisa, Cataldo, Giacinto, Cuveland, Jan, Falco, Alessandro, Gruttola, Daniele, Delagrange, Hugues, Castillo Sanchez, Eduardo, Deloff, Andrzej, Demanov, Vyacheslav, Marco, Nora, Denes, Ervin, Pasquale, Salvatore, Deppman, Airton, D’Erasmo, Ginevra, Rooij, Raoul, Bari, Domenico, Dietel, Thomas, Giglio, Carmelo, Liberto, Sergio, Mauro, Antonio, Nezza, Pasquale, Divia, Roberto, Djuvsland, Oeystein, Dobrin, Alexandru, Dobrowolski, Tadeusz, Dominguez, Isabel, Donigus, Benjamin, Dordic, Olja, Driga, Olga, Dubey, Anand, Ducroux, Laurent, Dupieux, Pascal, Majumdar, Mihir, Majumdar, A.K., Elia, Domenico, Emschermann, David, Engel, Heiko, Erdal, Hege, Espagnon, Bruno, Estienne, Magali, Esumi, Shinichi, Evans, David, Eyyubova, Gyulnara, Fabris, Daniela, Faivre, Julien, Falchieri, Davide, Fantoni, Alessandra, Fasel, Markus, Fearick, Roger, Fedunov, Anatoly, Fehlker, Dominik, Feldkamp, Linus, Felea, Daniel, Feofilov, Grigory, Tellez, Arturo, Ferretti, Alessandro, Ferretti, Roberta, Figiel, Jan, Figueredo, Marcel, Filchagin, Sergey, Fini, Rosa, Finogeev, Dmitry, Fionda, Fiorella, Fiore, Enrichetta, Floris, Michele, Foertsch, Siegfried, Foka, Panagiota, Fokin, Sergey, Fragiacomo, Enrico, Fragkiadakis, Michail, Frankenfeld, Ulrich, Fuchs, Ulrich, Furget, Christophe, Girard, Mario, Gaardhoje, Jens, Gagliardi, Martino, Gago, Alberto, Gallio, Mauro, Gangadharan, Dhevan, Ganoti, Paraskevi, Garabatos, Jose, Garcia-Solis, Edmundo, Garishvili, Irakli, Gerhard, Jochen, Germain, Marie, Geuna, Claudio, Gheata, Andrei, Gheata, Mihaela, Ghidini, Bruno, Ghosh, Premomoy, Gianotti, Paola, Girard, Martin, Giubellino, Paolo, Gladysz-Dziadus, Ewa, Glassel, Peter, Gomez, Ramon, Ferreiro, Elena, Gonzalez-Trueba, Laura, Gonzalez-Zamora, Pedro, Gorbunov, Sergey, Goswami, Ankita, Gotovac, Sven, Grabski, Varlen, Graczykowski, Lukasz, Grajcarek, Robert, Grelli, Alessandro, Grigoras, Costin, Grigoras, Alina, Grigoriev, Vladislav, Grigoryan, Ara, Grigoryan, Smbat, Grinyov, Boris, Grion, Nevio, Gros, Philippe, Grosse-Oetringhaus, Jan, Grossiord, Jean-Yves, Grosso, Raffaele, Guber, Fedor, Guernane, Rachid, Gutierrez, Cesar, Guerzoni, Barbara, Guilbaud, Maxime, Gulbrandsen, Kristjan, Gunji, Taku, Gupta, Anik, Gupta, Ramni, Gutbrod, Hans, Haaland, Oystein, Hadjidakis, Cynthia, Haiduc, Maria, Hamagaki, Hideki, Hamar, Gergoe, Han, Byounghee, Hanratty, Luke, Hansen, Alexander, Harmanova, Zuzana, Harris, John, Hartig, Matthias, Hasegan, Dumitru, Hatzifotiadou, Despoina, Hayrapetyan, Arsen, Heckel, Stefan, Heide, Markus, Helstrup, Haavard, Herghelegiu, Andrei, Corral, Gerardo, Herrmann, Norbert, Hetland, Kristin, Hicks, Bernard, Hille, Per, Hippolyte, Boris, Horaguchi, Takuma, Hori, Yasuto, Hristov, Peter, Hrivnacova, Ivana, Huang, Meidana, Huber, Sebastian, Humanic, Thomas, Hwang, Dae, Ichou, Raphaelle, Ilkaev, Radiy, Ilkiv, Iryna, Inaba, Motoi, Incani, Elisa, Innocenti, Pier, Innocenti, Gian, Ippolitov, Mikhail, Irfan, Muhammad, Ivan, Cristian, Ivanov, Marian, Ivanov, Vladimir, Ivanov, Andrey, Ivanytskyi, Oleksii, Jacholkowski, Adam, Jacobs, Peter, Jancurova, Lucia, Jang, Haeng, Jangal, Swensy, Janik, Rudolf, Janik, Malgorzata, Jayarathna, Sandun, Jena, Satyajit, Bustamante, Raul, Jirden, Lennart, Jones, Peter, Jung, Won, Jung, Hyung, Jusko, Anton, Kaidalov, Alexei, Kakoyan, Vanik, Kalcher, Sebastian, Kalinak, Peter, Kalisky, Matus, Kalliokoski, Tuomo, Kalweit, Alexander, Kanaki, Kalliopi, Kang, Ju, Kaplin, Vladimir, Uysal, Ayben, Karavichev, Oleg, Karavicheva, Tatiana, Karpechev, Evgeny, Kazantsev, Andrey, Kebschull, Udo, Keidel, Ralf, Khan, Palash, Khan, Mohisin, Khan, Shuaib, Khanzadeev, Alexei, Kharlov, Yury, Kileng, Bjarte, Kim, Jonghyun, Kim, Dong, Kim, Do, Kim, Jin, Kim, Minwoo, Kim, Seon, Kim, Se, Kim, Beomkyu, Kim, Taesoo, Kirsch, Stefan, Kisel, Ivan, Kiselev, Sergey, Kisiel, Adam, Klay, Jennifer, Klein, Jochen, Klein-Bosing, Christian, Kliemant, Michael, Kluge, Alexander, Knichel, Michael, Koch, Kathrin, Kohler, Markus, Kolojvari, Anatoly, Kondratiev, Valery, Kondratyeva, Natalia, Konevskih, Artem, Korneev, Andrey, Don, Chamath, Kour, Ravjeet, Kowalski, Marek, Kox, Serge, Meethaleveedu, Greeshma, Kral, Jiri, Kralik, Ivan, Kramer, Frederick, Kraus, Ingrid, Krawutschke, Tobias, Kretz, Matthias, Krivda, Marian, Krizek, Filip, Krus, Miroslav, Kryshen, Evgeny, Krzewicki, Mikolaj, Kucheriaev, Yury, Kuhn, Christian, Kuijer, Paul, Kurashvili, Podist, Kurepin, A.B., Kurepin, A., Kuryakin, Alexey, Kushpil, Svetlana, Kushpil, Vasily, Kvaerno, Henning, Kweon, Min, Kwon, Youngil, Guevara, Pedro, Lakomov, Igor, Langoy, Rune, Lara, Camilo, Lardeux, Antoine, Rocca, Paola, Lazzeroni, Cristina, Lea, Ramona, Bornec, Yves, Lee, Sung, Lee, Ki, Lefevre, Frederic, Lehnert, Joerg, Leistam, Lars, Lenhardt, Matthieu, Lenti, Vito, Leon, Hermes, Monzon, Ildefonso, Vargas, Hermes, Levai, Peter, Li, Xiaomei, Lien, Jorgen, Lietava, Roman, Lindal, Svein, Lindenstruth, Volker, Lippmann, Christian, Lisa, Michael, Liu, Lijiao, Loenne, Per-Ivar, Loggins, Vera, Loginov, Vitaly, Lohn, Stefan, Lohner, Daniel, Loizides, Constantinos, Loo, Kai, Lopez, Xavier, Torres, Ernesto, Lovhoiden, Gunnar, Lu, Xianguo, Luettig, Philipp, Lunardon, Marcello, Luo, Jiebin, Luparello, Grazia, Luquin, Lionel, Luzzi, Cinzia, Ma, Rongrong, Ma, Ke, Madagodahettige-Don, Dilan, Maevskaya, Alla, Mager, Magnus, Mahapatra, Durga, Maire, Antonin, Malaev, Mikhail, Cervantes, Ivonne, Malinina, Ludmila, Mal’Kevich, Dmitry, Malzacher, Peter, Mamonov, Alexander, Manceau, Loic, Mangotra, Lalit, Manko, Vladislav, Manso, Franck, Manzari, Vito, Mao, Yaxian, Marchisone, Massimiliano, Mares, Jiri, Margagliotti, Giacomo, Margotti, Anselmo, Marin, Ana, Markert, Christina, Martashvili, Irakli, Martinengo, Paolo, Martinez, Mario, Davalos, Arnulfo, Garcia, Gines, Martynov, Yevgen, Mas, Alexis, Masciocchi, Silvia, Masera, Massimo, Masoni, Alberto, Massacrier, Laure, Mastromarco, Mario, Mastroserio, Annalisa, Matthews, Zoe, Matyja, Adam, Mayani, Daniel, Mayer, Christoph, Mazer, Joel, Mazzoni, Aless...
    Journal of High Energy Physics, 2012, Vol.2012(7), pp.1-43 [Peer Reviewed Journal]
    Springer Science & Business Media B.V.