Title: Esophageal cancer: comparative effectiveness of treatment options Author:Cai, Xu; Lin, Steven Subject:Clinical Trials ; Oncology ; Medical Prognosis ; Surgery ; Disease ; Studies ; Cancer Therapies ; Radiation Therapy ; Chemotherapy ; Esophageal Cancer ; Health Risk Assessment ; Esophageal Cancer ; Treatment Modalities ; Comparative Effectiveness ; Imrt ; Proton Therapy Description:
Esophageal cancer is a lethal disease. Multimodal therapy has improved the survival and local control for locally advanced esophageal cancer compared to surgery alone. Neoadjuvant chemoradiotherapy (CRT) plus surgery is the accepted standard of care for operable esophageal cancer. Pathologic complete response is very common, ranging from 18% to 43%, and it is an independent favorable prognostic factor for survival. Salvage surgery after definitive CRT may be safe and feasible for patients with esophageal cancer who achieve pathologic complete response after neoadjuvant CRT. For inoperable cases, definitive CRT is an alternative treatment modality. Intensity-modulated radiation therapy may reduce treatment-related toxicities due to its better dose homogeneity and conformity compared to three-dimensional conformal radiotherapy. Proton therapy can further improve target conformity and normal tissue sparing when compared to photon therapy (three-dimensional conformal radiotherapy and intensity-modulated...
Is part of:
Comparative Effectiveness Research, 2016, Vol.6, pp.1-12
1179-8483 (E-ISSN); 10.2147/CER.S73805 (DOI)
The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis
Cai, Xu, Yang, Ming
Journal of Cancer Research and Clinical Oncology, 2012, Vol.138(4), pp.555-561
[Peer Reviewed Journal]
Title: Effect of spatial distance on search information correlation in complex systems Author:Zhao, TingTing; Cai, Xu Subject:spatial distance ; search information ; action radius ; assortative mixing Description:
Spatial distance has a remarkable effect on the attended mode of a network embedded in a certain space. First, we investigate how spatial restriction leads to information-information correlation that is strong, linear and positive in real networks. We then construct a two-dimensional space, define the action radius R for nodes of networks, and propose a class of models that depend on spatial distance. Information correlation of the models is consistent with that of real networks. The spatial distance plays a leading role in generating assortative mixing by degree, while the generation of disassortative mixing relies on both the degree of preferential attachment and spatial restriction.
Is part of:
Chinese Science Bulletin, 2011, Vol.56(34), pp.3671-3676
1001-6538 (ISSN); 1861-9541 (E-ISSN); 10.1007/s11434-011-4795-2 (DOI)
Stepped 2-Level Operation of Three-Port Modular DC/DC Converter Applied in HVDC Application