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    • Several versions

    Evaluation of algorithms for photon depth of interaction estimation for the TRIMAGE PET component

    Camarlinghi, Niccolo, Belcari, Nicola, Cerello, Piergiorgio, Sportelli, Giancarlo, Pennazio, Francesco, Zaccario, Emanuele, Del Guerra, Alberto
    EJNMMI Physics, 2015, Vol.2(Supplement 1), pp.1-1 [Peer Reviewed Journal]

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    Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 1: A radiobiological model study

    Ferrero, Veronica, Visonà, Giovanni, Dalmasso, Federico, Gobbato, Andrea, Cerello, Piergiorgio, Strigari, Lidia, Visentin, Sonja, Attili, Andrea
    Medical physics, May 2017, Vol.44(5), pp.1983-1992 [Peer Reviewed Journal]
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    Title: Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 1: A radiobiological model study
    Author: Ferrero, Veronica; Visonà, Giovanni; Dalmasso, Federico; Gobbato, Andrea; Cerello, Piergiorgio; Strigari, Lidia; Visentin, Sonja; Attili, Andrea
    Subject: Breast Cancer ; Gold Nanoparticles ; Radiosensitization ; Radiotherapy ; Treatment Planning ; Gold ; Breast Neoplasms -- Radiotherapy ; Metal Nanoparticles -- Therapeutic Use
    Description: Gold nanoparticles (GNPs) are being proposed in combination with radiotherapy to improve tumor control. However, the exact mechanisms underlying GNP radiosensitization are yet to be understood, thus, we present a new approach to estimate the nanoparticle-driven increase in radiosensitivity. A stochastic radiobiological model, derived from the Local Effect Model (LEM), was coupled with Monte Carlo simulations to estimate the increase in radiosensitivity produced by the interactions between photons and GNPs at nanometric scale. The model was validated using in vitro survival data of MDA-MB-231 breast cancer cells containing different concentrations of 2 nm diameter GNPs receiving different doses using 160 kVp, 6 MV, and 15 MV photons. A closed analytical formulation of the model was also derived and a study of RBE and TCP behavior was conducted. Results support the increased radiosensitivity due to GNP-driven dose inhomogeneities on a nanometric scale. The model is in good agreement with experimental clonogenic survival assays for 160 kVp, 6 MV, and 15 MV photons. The model suggests a RBE and TCP enhancement when lower energies and lower doses per fraction are used in the presence of GNPs. The evolution of the local effect model was implemented to assess cellular radiosensitization in the presence of GNPs and then validated with in vitro data. The model provides a useful framework to estimate the nanoparticle-driven radiosensitivity in treatment irradiations and could be applied to real clinical treatment predictions (described in a second part of this paper).
    Is part of: Medical physics, May 2017, Vol.44(5), pp.1983-1992
    Identifier: 2473-4209 (E-ISSN); 28236655 Version (PMID); 10.1002/mp.12180 (DOI)

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    Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study

    Strigari, Lidia, Ferrero, Veronica, Visonà, Giovanni, Dalmasso, Federico, Gobbato, Andrea, Cerello, Piergiorgio, Visentin, Sonja, Attili, Andrea
    Medical physics, May 2017, Vol.44(5), pp.1993-2001 [Peer Reviewed Journal]
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    Title: Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study
    Author: Strigari, Lidia; Ferrero, Veronica; Visonà, Giovanni; Dalmasso, Federico; Gobbato, Andrea; Cerello, Piergiorgio; Visentin, Sonja; Attili, Andrea
    Subject: Breast Cancer ; Gold Nanoparticles ; Radiosensitization ; Radiotherapy ; Treatment Planning ; Gold ; Breast Neoplasms -- Radiotherapy ; Metal Nanoparticles -- Therapeutic Use
    Description: In recent years, there has been growing interest in the use of gold nanoparticles (GNPs) combined with radiotherapy to improve tumor control. However, the complex interplay between GNP uptake and dose distribution in realistic clinical treatment are still somewhat unknown. The effects of different concentrations of 2 nm diameter GNP, ranging from 0 to 5×105 nanoparticles per tumoral cell, were theoretically investigated. A parametrization of the GNP distribution outside the target was carried out using a Gaussian standard deviation σ, from a zero value, relative to a selective concentration of GNPs inside the tumor volume alone, to 50mm, when GNPs are spatially distributed also in the healthy tissues surrounding the tumor. Treatment simulations of five patients with breast cancer were performed with 6 and 15 MV photons assuming a partial breast irradiation. A closed analytical reformulation of the Local Effect Model coupled with the estimation of local dose deposited around a GNP was validated using an in vitro study for MDA-MB-231 tumoral cells. The expected treatment outcome was quantified in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP) as a function of the spatially varying gold uptake. Breast cancer treatment planning simulations show improved treatment outcomes when GNPs are selectively concentrated in the tumor volume (i.e., σ = 0 mm). In particular, the TCP increases up to 18% for 5×105 nanoparticles per cell in the tumor region depending on the treatment schedules, whereas an improvement of the therapeutic index is observed only for concentrations of about 105 GNPs per tumoral cell and limited spatial distribution in the normal tissue. The model provides a useful framework to estimate the nanoparticle-driven radiosensitivity in breast cancer treatment irradiation, accounting for the complex interplay between dose and GNP uptake distributions.
    Is part of: Medical physics, May 2017, Vol.44(5), pp.1993-2001
    Identifier: 2473-4209 (E-ISSN); 28236658 Version (PMID); 10.1002/mp.12178 (DOI)

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    TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia

    Del Guerra, Alberto, Ahmad, Salleh, Avram, Mihai, Belcari, Nicola, Berneking, Arne, Biagi, Laura, Bisogni, Maria Giuseppina, Brandl, Felix, Cabello, Jorge, Camarlinghi, Niccolò, Cerello, Piergiorgio, Choi, Chang-Hoon, Coli, Silvia, Colpo, Sabrina, Fleury, Julien, Gagliardi, Vito, Giraudo, Giuseppe, Heekeren, Karsten, Kawohl
    European psychiatry : the journal of the Association of European Psychiatrists, April 2018, Vol.50, pp.7-20 [Peer Reviewed Journal]
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    Title: TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia
    Author: Del Guerra, Alberto; Ahmad, Salleh; Avram, Mihai; Belcari, Nicola; Berneking, Arne; Biagi, Laura; Bisogni, Maria Giuseppina; Brandl, Felix; Cabello, Jorge; Camarlinghi, Niccolò; Cerello, Piergiorgio; Choi, Chang-Hoon; Coli, Silvia; Colpo, Sabrina; Fleury, Julien; Gagliardi, Vito; Giraudo, Giuseppe; Heekeren, Karsten; Kawohl
    Subject: Biomarkers ; EEG ; Mr ; Pet ; Schizophrenia ; Trimodal Imaging ; Brain -- Diagnostic Imaging ; Electroencephalography -- Methods ; Magnetic Resonance Spectroscopy -- Methods ; Multimodal Imaging -- Methods ; Positron-Emission Tomography -- Methods ; Schizophrenia -- Diagnostic Imaging
    Description: Simultaneous PET/MR/EEG (Positron Emission Tomography - Magnetic Resonance - Electroencephalography), a new tool for the investigation of neuronal networks in the human brain, is presented here within the framework of the European Union Project TRIMAGE. The trimodal, cost-effective PET/MR/EEG imaging tool makes use of cutting edge technology both in PET and in MR fields. A novel type of magnet (1.5T, non-cryogenic) has been built together with a PET scanner that makes use of the most advanced photodetectors (i.e., SiPM matrices), scintillators matrices (LYSO) and digital electronics. The combined PET/MR/EEG system is dedicated to brain imaging and has an inner diameter of 260 mm and an axial Field-of-View of 160 mm. It enables the acquisition and assessment of molecular metabolic information with high spatial and temporal resolution in a given brain simultaneously. The dopaminergic system and the glutamatergic system in schizophrenic patients are investigated via PET, the same physiological/pathophysiological...
    Is part of: European psychiatry : the journal of the Association of European Psychiatrists, April 2018, Vol.50, pp.7-20
    Identifier: 1778-3585 (E-ISSN); 29358016 Version (PMID); 10.1016/j.eurpsy.2017.11.007 (DOI)

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    Corrigendum to "TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia" Eur Psychiatry 50 (2018) 7-20

    Del Guerra, Alberto, Ahmad, Salleh, Avram, Mihai, Belcari, Nicola, Berneking, Arne, Biagi, Laura, Bisogni, Maria Giuseppina, Brandl, Felix, Cabello, Jorge, Camarlinghi, Niccolò, Cerello, Piergiorgio, Choi, Chang-Hoon, Coli, Silvia, Colpo, Sabrina, Fleury, Julien, Gagliardi, Vito, Giraudo, Giuseppe, Heekeren, Karsten, Kawohl
    European psychiatry : the journal of the Association of European Psychiatrists, June 2018, Vol.51, pp.104-105 [Peer Reviewed Journal]
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    Title: Corrigendum to "TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia" Eur Psychiatry 50 (2018) 7-20
    Author: Del Guerra, Alberto; Ahmad, Salleh; Avram, Mihai; Belcari, Nicola; Berneking, Arne; Biagi, Laura; Bisogni, Maria Giuseppina; Brandl, Felix; Cabello, Jorge; Camarlinghi, Niccolò; Cerello, Piergiorgio; Choi, Chang-Hoon; Coli, Silvia; Colpo, Sabrina; Fleury, Julien; Gagliardi, Vito; Giraudo, Giuseppe; Heekeren, Karsten; Kawohl
    Subject: Medicine;
    Is part of: European psychiatry : the journal of the Association of European Psychiatrists, June 2018, Vol.51, pp.104-105
    Identifier: 1778-3585 (E-ISSN); 29885749 Version (PMID); 10.1016/j.eurpsy.2018.05.007 (DOI)

    • Several versions

    Depth of interaction determination in monolithic scintillator with double side SiPM readout

    Morrocchi, Matteo, Ambrosi, Giovanni, Bisogni, Maria, Bosi, Filippo, Boretto, Marco, Cerello, Piergiorgio, Ionica, Maria, Liu, Ben, Pennazio, Francesco, Piliero, Maria, Pirrone, Giovanni, Postolache, Vasile, Wheadon, Richard, Del Guerra, Alberto
    EJNMMI Physics, 2017, Vol.4(1), pp.1-25 [Peer Reviewed Journal]

    • Several versions

    Combination of computer-aided detection algorithms for automatic lung nodule identification

    Camarlinghi, Niccolò, Gori, Ilaria, Retico, Alessandra, Bellotti, Roberto, Bosco, Paolo, Cerello, Piergiorgio, Gargano, Gianfranco, Lopez Torres, Ernesto, Megna, Rosario, Peccarisi, Marco, Fantacci, Maria
    International Journal of Computer Assisted Radiology and Surgery, 2012, Vol.7(3), pp.455-464 [Peer Reviewed Journal]

    • Several versions

    Online proton therapy monitoring: clinical test of a Silicon-photodetector-based in-beam PET

    Ferrero, Veronica, Fiorina, Elisa, Morrocchi, Matteo, Pennazio, Francesco, Baroni, Guido, Battistoni, Giuseppe, Belcari, Nicola, Camarlinghi, Niccolo', Ciocca, Mario, Del Guerra, Alberto, Donetti, Marco, Giordanengo, Simona, Giraudo, Giuseppe, Patera, Vincenzo, Peroni, Cristiana, Rivetti, Angelo, Rolo, Manuel Dionisio Da Rocha, Rossi, Sandro, Rosso
    Scientific reports, 06 March 2018, Vol.8(1), pp.4100 [Peer Reviewed Journal]

    • Several versions

    Automatic Lung Segmentation in CT Images with Accurate Handling of the Hilar Region

    De Nunzio, Giorgio, Tommasi, Eleonora, Agrusti, Antonella, Cataldo, Rosella, De Mitri, Ivan, Favetta, Marco, Maglio, Silvio, Massafra, Andrea, Quarta, Maurizio, Torsello, Massimo, Zecca, Ilaria, Bellotti, Roberto, Tangaro, Sabina, Calvini, Piero, Camarlinghi, Niccolò, Falaschi, Fabio, Cerello, Piergiorgio, Oliva, Piernicola
    Journal of Digital Imaging, 2011, Vol.24(1), pp.11-27 [Peer Reviewed Journal]

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    INSIDE in-beam positron emission tomography system for particle range monitoring in hadrontherapy

    Bisogni, Maria Giuseppina, Attili, Andrea, Battistoni, Giuseppe, Belcari, Nicola, Camarlinghi, Niccolo', Cerello, Piergiorgio, Coli, Silvia, Del Guerra, Alberto, Ferrari, Alfredo, Ferrero, Veronica, Fiorina, Elisa, Giraudo, Giuseppe, Kostara, Eleftheria, Morrocchi, Matteo, Pennazio, Francesco, Peroni, Cristiana, Piliero, Maria Antonietta, Pirrone, Giovanni, Rivetti
    Journal of medical imaging (Bellingham, Wash.), January 2017, Vol.4(1), pp.011005 [Peer Reviewed Journal]
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    Title: INSIDE in-beam positron emission tomography system for particle range monitoring in hadrontherapy
    Author: Bisogni, Maria Giuseppina; Attili, Andrea; Battistoni, Giuseppe; Belcari, Nicola; Camarlinghi, Niccolo'; Cerello, Piergiorgio; Coli, Silvia; Del Guerra, Alberto; Ferrari, Alfredo; Ferrero, Veronica; Fiorina, Elisa; Giraudo, Giuseppe; Kostara, Eleftheria; Morrocchi, Matteo; Pennazio, Francesco; Peroni, Cristiana; Piliero, Maria Antonietta; Pirrone, Giovanni; Rivetti
    Subject: Hadrontherapy ; Particle Range Verification ; Positron Emission Tomography
    Description: The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators of the treatment plan correctness. Among the available imaging techniques, positron emission tomography (PET) has long been investigated and then clinically applied to proton and carbon beams. In 2013, the Innovative Solutions for Dosimetry in Hadrontherapy (INSIDE) collaboration proposed an innovative bimodal imaging concept that combines an in-beam PET scanner with a tracking system for charged particle imaging. This paper presents the general architecture of the INSIDE project but focuses on the in-beam PET scanner that has been designed to reconstruct the particles range with millimetric resolution within a fraction of the dose delivered in a treatment of head and neck tumors. The in-beam PET scanner has been recently installed at the Italian National Center of Oncologic Hadrontherapy (CNAO) in Pavia, Italy, and the commissioning...
    Is part of: Journal of medical imaging (Bellingham, Wash.), January 2017, Vol.4(1), pp.011005
    Identifier: 2329-4302 (ISSN); 27981069 Version (PMID)