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    Patterns of genome evolution that have accompanied host adaptation in Salmonella

    Langridge, Gemma C, Fookes, Maria, Connor, Thomas R, Feltwell, Theresa, Feasey, Nicholas, Parsons, Bryony N, Seth-Smith, Helena M B, Barquist, Lars, Stedman, Anna, Humphrey, Tom, Wigley, Paul, Peters, Sarah E, Maskell, Duncan J, Corander, Jukka, Chabalgoity, Jose A, Barrow, Paul, Parkhill, Julian, Dougan, Gordon, Thomson, Nicholas R
    Proceedings of the National Academy of Sciences of the United States of America, 20 January 2015, Vol.112(3), pp.863-8 [Peer Reviewed Journal]

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    Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice

    Bascuas Castillo, Thaïs, Moreno, María, Grille, Sofía, Chabalgoity, José A.
    Frontiers in Immunology, 2018, 9
    2018
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    Title: Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice
    Author: Bascuas Castillo, Thaïs; Moreno, María; Grille, Sofía; Chabalgoity, José A.
    Date: 2018
    Subject: Non-Hodgkin lymphoma - Chemotherapy - CHOP - Salmonella - Immunotherapy
    Description: We have previously shown that Salmonella immunotherapy is effective to treat B-cell non-Hodgkin lymphoma (B-NHL) in mice. However, this model involves animals with high tumor burden, whereas in the clinics B-NHL patients are usually treated with chemotherapy (CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisone) as first-line therapy prior to immunotherapy. Recently, we have described a NHL-B preclinical model using CHOP chemotherapy to achieve MRD in immunocompetent animals that closely resemble patients’ conditions. In this work, we assessed the efficacy of Salmonella immunotherapy in B-NHL-bearing mice undergoing chemotherapy. Salmonella administration significantly delayed tumor growth and prolonged survival of chemotherapy-treated NHL-bearing animals. Mice receiving the CHOP–Salmonella combined therapy showed increased numbers of tumor-infiltrating leukocytes and a different profile of cytokines and chemokines expressed in the tumor microenvironment. Further, Salmonella immunotherapy in CHOP-treated animals also enhanced NK cells cytotoxic activity as well as induced systemic lymphoma-specific humoral and cellular responses. Chemotherapy treatment profoundly impacted on the general health status of recipient animals, but those receiving Salmonella showed significantly better overall body condition. Altogether, the results clearly demonstrated that Salmonella immunotherapy could be safely used in individuals under CHOP treatment, resulting in a better prognosis. These results give strong support to consider Salmonella as a neoadjuvant therapy in a clinical setting.
    Is part of: Frontiers in Immunology, 2018, 9

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    Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis

    Tadesse, Getachew, Tessema, Tesfaye S, Beyene, Getenet, Aseffa, Abraham
    PLoS ONE, 2018, Vol.13(2) [Peer Reviewed Journal]

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    Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide

    Ivanov, Stoyan, Fontaine, Josette, Paget, Christophe, Macho Fernandez, Elodie, Van Maele, Laurye, Renneson, Joelle, Maillet, Isabelle, Wolf, Natalia Muñoz, Rial, Analia, Léger, Hélène, Ryffel, Bernard, Frisch, Benoit, Chabalgoity, José A, Sirard, Jean Claude, Benecke, Arndt, Faveeuw, Christelle, Trottein, François
    The Journal of infectious diseases, 01 September 2012, Vol.206(5), pp.723-34 [Peer Reviewed Journal]

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    Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice

    Bascuas, Thais, Moreno, María, Grille, Sofía, Chabalgoity, José A
    Frontiers in immunology, 2018, Vol.9, pp.7 [Peer Reviewed Journal]

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    Evaluation of pathogenicity of Salmonella Gallinarum strains harbouring deletions in genes whose orthologues are conserved pseudogenes in S . Pullorum

    Alves Batista, Diego Felipe, De Freitas Neto, Oliveiro Caetano, Maria De Almeida, Adriana, Maboni, Grazieli, De Carvalho, Tatiane Furtado, De Carvalho, Thaynara Parente, Barrow, Paul Andrew, Berchieri, Angelo
    PLoS ONE, 2018, Vol.13(7) [Peer Reviewed Journal]

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    Characterization of Salmonella enterica isolates causing bacteremia in Lima, Peru, using multiple typing methods

    Silva, Claudia, Betancor, Laura, García, Coralith, Astocondor, Lizeth, Hinostroza, Noemí, Bisio, Julieta, Rivera, Javier, Perezgasga, Lucía, Pérez Escanda, Victoria, Yim, Lucía, Jacobs, Jan, García-Del Portillo, Francisco, Chabalgoity, José A
    PLoS ONE, 2017, Vol.12(12) [Peer Reviewed Journal]

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    Native flagellin does not protect mice against an experimental Proteus mirabilis ascending urinary tract infection and neutralizes the protective effect of MrpA fimbrial protein

    Scavone, Paola, Umpiérrez, Ana, Rial, Analía, Chabalgoity, José A, Zunino, Pablo
    Antonie van Leeuwenhoek, June 2014, Vol.105(6), pp.1139-48 [Peer Reviewed Journal]
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    Title: Native flagellin does not protect mice against an experimental Proteus mirabilis ascending urinary tract infection and neutralizes the protective effect of MrpA fimbrial protein
    Author: Scavone, Paola; Umpiérrez, Ana; Rial, Analía; Chabalgoity, José A; Zunino, Pablo
    Subject: Antigens, Bacterial -- Immunology ; Bacterial Proteins -- Immunology ; Bacterial Vaccines -- Immunology ; Flagellin -- Immunology ; Proteus Infections -- Prevention & Control ; Proteus Mirabilis -- Immunology ; Urinary Tract Infections -- Prevention & Control
    Description: Proteus mirabilis expresses several virulence factors including MR/P fimbriae and flagella. Bacterial flagellin has frequently shown interesting adjuvant and protective properties in vaccine formulations. However, native P. mirabilis flagellin has not been analyzed so far. Native P. mirabilis flagellin was evaluated as a protective antigen and as an adjuvant in co-immunizations with MrpA (structural subunit of MR/P fimbriae) using an ascending UTI model in the mouse. Four groups of mice were intranasally treated with either MrpA, native flagellin, both proteins and PBS. Urine and blood samples were collected before and after immunization for specific antibodies determination. Cytokine production was assessed in immunized mice splenocytes cultures. Mice were challenged with P. mirabilis, and bacteria quantified in kidneys and bladders. MrpA immunization induced serum and urine specific anti-MrpA antibodies while MrpA coadministered with native flagellin did not. None of the animals developed...
    Is part of: Antonie van Leeuwenhoek, June 2014, Vol.105(6), pp.1139-48
    Identifier: 1572-9699 (E-ISSN); 24771125 Version (PMID); 10.1007/s10482-014-0175-7 (DOI)

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    Synthesis of metallo-β-lactamase VIM-2 is associated with a fitness reduction in Salmonella enterica Serovar Typhimurium

    Cordeiro, Nicolás F, Chabalgoity, José A, Yim, Lucía, Vignoli, Rafael
    Antimicrobial agents and chemotherapy, November 2014, Vol.58(11), pp.6528-35 [Peer Reviewed Journal]
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    Title: Synthesis of metallo-β-lactamase VIM-2 is associated with a fitness reduction in Salmonella enterica Serovar Typhimurium
    Author: Cordeiro, Nicolás F; Chabalgoity, José A; Yim, Lucía; Vignoli, Rafael
    Subject: Drug Resistance, Multiple, Bacterial -- Genetics ; Genetic Fitness -- Genetics ; Salmonella Infections -- Drug Therapy ; Salmonella Typhimurium -- Pathogenicity ; Beta-Lactamases -- Genetics
    Description: Antibiotic resistance, especially due to β-lactamases, has become one of the main obstacles in the correct treatment of Salmonella infections; furthermore, antibiotic resistance determines a gain of function that may encompass a biological cost, or fitness reduction, to the resistant bacteria. The aim of this work was to determine in vitro if the production of the class B β-lactamase VIM-2 determined a fitness cost for Salmonella enterica serovar Typhimurium. To that end the gene blaVIM-2 was cloned into the virulent strain S. Typhimurium SL1344, using both the tightly regulated pBAD22 vector and the natural plasmid pST12, for inducible and constitutive expression, respectively. Fitness studies were performed by means of motility, growth rate, invasiveness in epithelial cells, and plasmid stability. The expression of blaVIM-2 was accompanied by alterations in micro- and macroscopic morphology and reduced growth rate and motility, as well as diminished invasiveness in epithelial cells. These...
    Is part of: Antimicrobial agents and chemotherapy, November 2014, Vol.58(11), pp.6528-35
    Identifier: 1098-6596 (E-ISSN); 25136026 Version (PMID); 10.1128/AAC.02847-14 (DOI)

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    Sublingual immunotherapy as an alternative to induce protection against acute respiratory infections

    Muñoz-Wolf, Natalia, Rial, Analía, Saavedra, José M, Chabalgoity, José A
    Journal of visualized experiments : JoVE, 30 August 2014(90) [Peer Reviewed Journal]
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    Title: Sublingual immunotherapy as an alternative to induce protection against acute respiratory infections
    Author: Muñoz-Wolf, Natalia; Rial, Analía; Saavedra, José M; Chabalgoity, José A
    Subject: Lung -- Immunology ; Pneumococcal Vaccines -- Administration & Dosage ; Pneumonia, Pneumococcal -- Prevention & Control ; Streptococcus Pneumoniae -- Immunology
    Description: Sublingual route has been widely used to deliver small molecules into the bloodstream and to modulate the immune response at different sites. It has been shown to effectively induce humoral and cellular responses at systemic and mucosal sites, namely the lungs and urogenital tract. Sublingual vaccination can promote protection against infections at the lower and upper respiratory tract; it can also promote tolerance to allergens and ameliorate asthma symptoms. Modulation of lung's immune response by sublingual immunotherapy (SLIT) is safer than direct administration of formulations by intranasal route because it does not require delivery of potentially harmful molecules directly into the airways. In contrast to intranasal delivery, side effects involving brain toxicity or facial paralysis are not promoted by SLIT. The immune mechanisms underlying SLIT remain elusive and its use for the treatment of acute lung infections has not yet been explored. Thus, development of appropriate animal...
    Is part of: Journal of visualized experiments : JoVE, 30 August 2014(90)
    Identifier: 1940-087X (E-ISSN); 25225769 Version (PMID); 10.3791/52036 (DOI)