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    Systematic and comprehensive investigation of the toxicity of curcuminoid‑essential oil complex: A bioavailable turmeric formulation

    Aggarwal, Madan L, Chacko, Karampendethu M, Kuruvilla, Binu T
    Molecular medicine reports, January 2016, Vol.13(1), pp.592-604 [Peer Reviewed Journal]
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    Title: Systematic and comprehensive investigation of the toxicity of curcuminoid‑essential oil complex: A bioavailable turmeric formulation
    Author: Aggarwal, Madan L; Chacko, Karampendethu M; Kuruvilla, Binu T
    Subject: Curcumin -- Toxicity ; Oils, Volatile -- Toxicity
    Description: Curcumin, the active component present in Curcuma longa of the family Zingiberaceae, has a number of pharmacological effects, including potential anti‑inflammatory activity. One of the major limitations of curcumin/turmeric extract is its poor absorption through the gastrointestinal tract. Several approaches have been adopted to increase the bioavailability of curcumin, including loading curcumin into liposomes or nanoparticles, complexation with phospholipids, addition of essential oils and synthesizing structural analogues of curcumin. In the present study, the toxicity and safety of one such bioavailable turmeric formulation, curcuminoid‑essential oil complex (CEC), the toxicity profile of which has not been reported, were examined using in vivo and in vitro models, as per the guidelines of the Organisation for Economic Co-operation and Development. Investigations of acute toxicity study were performed in rats and mice, and the results revealed no signs and symptoms or toxicity or mortality...
    Is part of: Molecular medicine reports, January 2016, Vol.13(1), pp.592-604
    Identifier: 1791-3004 (E-ISSN); 26648561 Version (PMID); 10.3892/mmr.2015.4579 (DOI)