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    Cross-Ethnicity Measurement Equivalence of Family Coping for Breast Cancer Survivors

    Lim, Jung-Won, Townsend, Aloen
    Research on social work practice, November 2012, Vol.22(6), p.689 [Peer Reviewed Journal]
    ERIC (U.S. Dept. of Education)
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    Title: Cross-Ethnicity Measurement Equivalence of Family Coping for Breast Cancer Survivors
    Author: Lim, Jung-Won; Townsend, Aloen
    Subject: Quality of Life ; Ethnicity ; Coping ; Cancer ; Family Relationship ; Chinese Americans ; Factor Structure ; Structural Equation Models ; Korean Americans ; Measures (Individuals) ; Social Support Groups ; Emotional Disturbances ; Cultural Awareness ; Measurement ; California ; Social Welfare & Social Work ; Psychology
    Description: Objective: The current study examines the equivalence of a measure of family coping, the Family Crisis Oriented Personal Evaluation scales (F-COPES), in Chinese American and Korean American breast cancer survivors (BCS). Methods: Factor structure and cross-ethnicity equivalence of the F-COPES were tested using structural equation modeling with 157 Chinese American and Korean American BCS in California. Results: Of the original F-COPES subscales, acquiring social support, reframing, and passive appraisal did not adequately fit the data. Thus, a modified five-factor structure of the F-COPES was created. The modified F-COPES was validated with respect to quality of life, psychological distress, and family communication. Conclusions: The findings illustrate the importance of cross-ethnicity measurement testing and provide a rationale for developing culturally tailored measurements for ethnic minority populations. (Contains 5 tables and 2 figures.)
    Is part of: Research on social work practice, November 2012, Vol.22(6), p.689
    Identifier: 1049-7315 (ISSN); 1552-7581 (E-ISSN); 10.1177/1049731512448933 (DOI)

    • Several versions

    Expression Screening of Fusion Partners from an E. coli Genome for Soluble Expression of Recombinant Proteins in a Cell-Free Protein Synthesis System (Cell-Free Expression Screening of Fusion Partners)

    Ahn, Jin-Ho, Keum, Jung-Won, Kim, Dong-Myung
    PLoS ONE, 2011, Vol.6(11), p.e26875 [Peer Reviewed Journal]

    • Several versions

    A debug scheme to improve the error identification in post-silicon validation

    Choi, Inhyuk, Jung, Won, Oh, Hyunggoy, Kang, Sungho
    PLoS ONE, 2018, Vol.13(9) [Peer Reviewed Journal]

    • Several versions

    Influence of Iron Regulation on the Metabolome of Cryptococcus neoformans (Iron Regulation on Metabolome of C. neoformans)

    Choi, Jung Nam, Kim, Jeongmi, Kim, Jiyoung, Jung, Won Hee, Lee, Choong Hwan
    PLoS ONE, 2012, Vol.7(7), p.e41654 [Peer Reviewed Journal]

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    Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription

    Martell, Danya J., Joshi, Chandra P., Gaballa, Ahmed, Santiago, Ace George, Chen, Tai-Yen, Jung, Won, Helmann, John D., Chen, Peng
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Vol.112(44), pp.13467-13472 [Peer Reviewed Journal]
    Archival Journals (JSTOR)
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    Title: Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription
    Author: Martell, Danya J.; Joshi, Chandra P.; Gaballa, Ahmed; Santiago, Ace George; Chen, Tai-Yen; Jung, Won; Helmann, John D.; Chen, Peng
    Subject: RNA Polymerases – Chemical Properties ; RNA Polymerases – Research ; Chemical Kinetics – Research ; Transcription (Genetics) – Research;
    Description: Metalloregulators respond to metal ions to regulate transcription of metal homeostasis genes. MerR-family metalloregulators act on σ 70 -dependent suboptimal promoters and operate via a unique DNA distortion mechanism in which both the apo and holo forms of the regulators bind tightly to their operator sequence, distorting DNA structure and leading to transcription repression or activation, respectively. It remains unclear how these metalloregulator–DNA interactions are coupled dynamically to RNA polymerase (RNAP) interactions with DNA for transcription regulation. Using single-molecule FRET, we study how the copper efflux regulator (CueR)—a Cu⁺-responsive MerR-family metalloregulator—modulates RNAP interactions with CueR’s cognate suboptimal promoter P cop A, and how RNAP affects CueR–P cop A interactions. We find that RNAP can form two noninterconverting complexes at P cop A in the absence of nucleotides: a dead-end complex and an open complex, constituting a branched interaction pathway that is distinct from the linear pathway prevalent for transcription initiation at optimal promoters. Capitalizing on this branched pathway, CueR operates via a “biased sampling” instead of “dynamic equilibrium shifting” mechanism in regulating transcription initiation; it modulates RNAP’s binding–unbinding kinetics, without allowing interconversions between the deadend and open complexes. Instead, the apo-repressor form reinforces the dominance of the dead-end complex to repress transcription, and the holo-activator form shifts the interactions toward the open complex to activate transcription. RNAP, in turn, locks CueR binding at P cop A into its specific binding mode, likely helping amplify the differences between apo- and holo-CueR in imposing DNA structural changes. Therefore, RNAP and CueR work synergistically in regulating transcription.
    Is part of: Proceedings of the National Academy of Sciences of the United States of America, 2015, Vol.112(44), pp.13467-13472
    Identifier: 00278424 (ISSN); 10916490 (E-ISSN)

    • Several versions

    Predicting physical quality of life among a multiethnic sample of breast cancer survivors

    Ashing-Giwa, Kimlin, Lim, Jung-Won
    Quality of Life Research, 2010, Vol.19(6), pp.789-802 [Peer Reviewed Journal]

    • Several versions

    Is family functioning and communication associated with health-related quality of life for Chinese- and Korean-American breast cancer survivors?

    Lim, Jung-won, Ashing-Giwa, Kimlin
    Quality of Life Research, 2013, Vol.22(6), pp.1319-1329 [Peer Reviewed Journal]

    • Several versions

    Alveolar Macrophages Play a Key Role in Cockroach-Induced Allergic Inflammation via TNF-α Pathway (The Role of Macrophage in Cockroach-Induced Asthma)

    Kim, Joo Young, Sohn, Jung Ho, Choi, Je-Min, Lee, Jae-Hyun, Hong, Chein-Soo, Lee, Joo-Shil, Park, Jung-Won
    2012, Vol.7(10), p.e47971 [Peer Reviewed Journal]

    • Several versions

    Obesity Increases Airway Hyperresponsiveness via the TNF-α Pathway and Treating Obesity Induces Recovery

    Kim, Joo Young, Sohn, Jung-Ho, Lee, Jae-Hyun, Park, Jung-Won
    PLoS ONE, 2015, Vol.10(2) [Peer Reviewed Journal]

    • Several versions

    Light Transmission and Preference of Eye Patches for Occlusion Treatment

    Heo, Hwan, Park, Jung Won, Park, Sang Woo
    PLoS ONE, 2013, Vol.8(6) [Peer Reviewed Journal]