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    Intermolecular transmembrane domain interactions activate integrin αIIbβ3

    Ye, Feng, Kim, Se-Jong, Kim, Chungho
    The Journal of biological chemistry, 27 June 2014, Vol.289(26), pp.18507-13 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Intermolecular transmembrane domain interactions activate integrin αIIbβ3
    Author: Ye, Feng; Kim, Se-Jong; Kim, Chungho
    Subject: Bimolecular Fluorescence Complementation ; Fluorescence ; Integrin ; Integrin Activation ; Integrin Clustering ; Platelet ; Protein-Protein Interaction ; Thrombosis ; Transmembrane Domain ; Cell Membrane -- Metabolism ; Platelet Glycoprotein Gpiib-Iiia Complex -- Chemistry
    Description: Integrins are the major cell adhesion molecules responsible for cell attachment to the extracellular matrix. The strength of integrin-mediated adhesion is controlled by the affinity of individual integrins (integrin activation) as well as by the number of integrins involved in such adhesion. The positive correlation between integrin activation and integrin clustering had been suggested previously, but several trials to induce integrin clustering by dimerization of the transmembrane domain or tail region of integrin α subunits failed to demonstrate any change in integrin activation. Here, using platelet integrin αIIbβ3 as a model system, we showed that there is intermolecular lateral interaction between integrins through the transmembrane domains, and this interaction can enhance the affinity state of integrins. In addition, when integrin clustering was induced through heteromeric lateral interactions using bimolecular fluorescence complementation, we could observe a significant increase...
    Is part of: The Journal of biological chemistry, 27 June 2014, Vol.289(26), pp.18507-13
    Identifier: 1083-351X (E-ISSN); 24838247 Version (PMID); 10.1074/jbc.M113.541888 (DOI)

    • Several versions

    Multidimensional Measures of Impulsivity in Obsessive-Compulsive Disorder: Cannot Wait and Stop

    Sohn, Sung Yun, Kang, Jee In, Namkoong, Kee, Kim, Se Joo
    PLoS ONE, 2014, Vol.9(11) [Peer Reviewed Journal]

    • Several versions

    Lack of Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Alexithymia: Evidence from Patients with Obsessive-Compulsive Disorder

    Koh, Min Jung, Kim, Wonji, Kang, Jee In, Namkoong, Kee, Kim, Se Joo
    PLoS ONE, 2015, Vol.10(11) [Peer Reviewed Journal]

    • Several versions

    Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population

    Kim, Hae Won, Kang, Jee In, Hwang, Eun Hee, Kim, Se Joo
    PLoS ONE, 2018, Vol.13(1) [Peer Reviewed Journal]

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    Functional expression and extension of staphylococcal staphyloxanthin biosynthetic pathway in Escherichia coli

    Kim, Se Hyeuk, Lee, Pyung Cheon
    The Journal of biological chemistry, 22 June 2012, Vol.287(26), pp.21575-83 [Peer Reviewed Journal]
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    Title: Functional expression and extension of staphylococcal staphyloxanthin biosynthetic pathway in Escherichia coli
    Author: Kim, Se Hyeuk; Lee, Pyung Cheon
    Subject: Gene Expression Regulation, Bacterial ; Aldehyde Oxidoreductases -- Biosynthesis ; Bacterial Proteins -- Biosynthesis ; Escherichia Coli -- Metabolism ; Staphylococcus Aureus -- Metabolism ; Xanthophylls -- Chemistry
    Description: The biosynthetic pathway for staphyloxanthin, a C(30) carotenoid biosynthesized by Staphylococcus aureus, has previously been proposed to consist of five enzymes (CrtO, CrtP, CrtQ, CrtM, and CrtN). Here, we report a missing sixth enzyme, 4,4'-diaponeurosporen-aldehyde dehydrogenase (AldH), in the staphyloxanthin biosynthetic pathway and describe the functional expression of the complete staphyloxanthin biosynthetic pathway in Escherichia coli. When we expressed the five known pathway enzymes through artificial synthetic operons and the wild-type operon (crtOPQMN) in E. coli, carotenoid aldehyde intermediates such as 4,4'-diaponeurosporen-4-al accumulated without being converted into staphyloxanthin or other intermediates. We identified an aldH gene located 670 kilobase pairs from the known staphyloxanthin gene cluster in the S. aureus genome and an aldH gene in the non-staphyloxanthin-producing Staphylococcus carnosus genome. These two putative enzymes catalyzed the missing oxidation reaction...
    Is part of: The Journal of biological chemistry, 22 June 2012, Vol.287(26), pp.21575-83
    Identifier: 1083-351X (E-ISSN); 22535955 Version (PMID); 10.1074/jbc.M112.343020 (DOI)

    • Several versions

    Sustaining Production Chains through Financial Linkages

    Kim, Se-Jik, Shin, Hyun Song
    American Economic Review, 2012, Vol.102(3), pp.402-406 [Peer Reviewed Journal]

    • Several versions

    Cancer Association Study of Aminoacyl-tRNA Synthetase Signaling Network in Glioblastoma (Aminoacyl-tRNA Synthetase in Glioblastoma)

    Kim, Yong-Wan, Kwon, ChangHyuk, Liu, Juinn-Lin, Kim, Se Hoon, Kim, Sunghoon
    2012, Vol.7(8), p.e40960 [Peer Reviewed Journal]

    • Several versions

    Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons

    Kim, Se-Jeong, Park, Goon Ho, Kim, Donghoon, Lee, Jaekwang, Min, Hyejung, Wall, Estelle, Lee, C Justin, Simon, Melvin I, Lee, Sung Joong, Han, Sang-Kyou
    Proceedings of the National Academy of Sciences of the United States of America, 22 February 2011, Vol.108(8), pp.3371-6 [Peer Reviewed Journal]

    • Several versions

    Marine bacteria: potential sources for compounds to overcome antibiotic resistance

    Eom, Sung-Hwan, Kim, Young-Mog, Kim, Se-Kwon
    Applied Microbiology and Biotechnology, 2013, Vol.97(11), pp.4763-4773 [Peer Reviewed Journal]

    • Several versions

    Development of a Korean version of the Cancer Therapy Satisfaction Questionnaire (CTSQ): cross-cultural adaptation, reliability, and validity

    Park, So Jeong, An, Soo Min, Kim, Se Hyun
    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, March 2013, Vol.22(2), pp.431-6 [Peer Reviewed Journal]