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    • Several versions

    Sequence error storms and the landscape of mutations in cancer

    Kirsch, Stefan, Klein, Christoph A
    Proceedings of the National Academy of Sciences of the United States of America, 04 September 2012, Vol.109(36), pp.14289-90 [Peer Reviewed Journal]

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    Title: Einfluss der Zytokine der Interleukin-10-Familie auf die kutane Wundheilung : The effect of cytokines of the Interleukin-10-family on cutaneous wound healing
    Author: Kirsch, Stefan
    Contributor: N.n.
    Publisher: Berlin: Freie Universität Berlin Universitätsbibliothek
    Date: 2013
    Subject: 610 Medizin Und Gesundheit ; 610 Medical Sciences; Medicine ; Ddc:610 ; Il-10 Cytokines ; Il-24 ; Il-22r1 ; Cutaneous Wound Healing
    Description: Cutaneous wound healing is a complex, regenerative process, which is regulated by cytokines and growth factors. Studies regarding the biology of IL-10 cytokines demonstrate that these mediators seem to play a role in skin homeostasis. They induce regenerative effects in keratinocytes after binding to IL-22R1 and IL-20R1 receptor complexes. The aim of this study is to clarify whether IL-10 cytokines play a role in cutaneous wound healing. To identify biological functions of the IL-10 cytokines, in vivo studies were conducted using IL-22R1- and IL-20R1 deficient mice as well as the respective wildtype strain. At defined time points post wounding, the wounds were macroscopically analyzed and further studied by applying biochemical methods (qPCR, histology, Western Blot, ELISA). Gene expression analysis in unwounded and wounded skin revealed, that among the IL-10 cytokines IL-19 and IL-24 were highly upregulated with an expression maximum during the early wound healing phase. No differences of the wound area during the healing process could be identified between IL-20R1 deficient mice and the wildtype animals. In contrast, IL-22R1 deficient mice displayed an impaired wound healing response characterized by a delayed reepithelisation during the first 3 days after wounding. More physiological studies were comprised by genome wide microarray analysis and subsequent validation by qPCR. Based on these experiments, it turned out that Serine Peptidase Inhibitor A1 (Serpin A1) was significantly lower expressed in wounds 3 days post wounding of IL-22R1 deficient mice compared to the wildtype wounds. Topical application of Serpin A1 solution on wounds of IL-22R1 deficient mice for 24h during the early wound healing phase caused a wound healing response, which was not impaired compared to the wildtype animals. Additional in vitro experiments identified IL-24 as potential inducer of Serpin A1 in keratinocytes. Based on this study, IL-24 can be considered as an essential cytokine for the cutaneous wound healing process through binding to the IL-22R1/IL-20R2 receptor complex. The interaction between IL-24 and IL-22R1/IL-20R2 recepor complexes is a key process for the induction of Serpin A1 in keratinocytes. The newly identified role of IL-24 can be beneficial for the regulation of inflammatory conditions in wounds and eventually for future therapies of chronic wounds.

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    Metal-free reactions of alkynes via electrophilic iodocarbocyclizations

    Palisse, Adeline, Kirsch, Stefan F
    Organic & biomolecular chemistry, 28 October 2012, Vol.10(40), pp.8041-7 [Peer Reviewed Journal]
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    Title: Metal-free reactions of alkynes via electrophilic iodocarbocyclizations
    Author: Palisse, Adeline; Kirsch, Stefan F
    Subject: Alkynes -- Chemistry ; Halogens -- Chemistry ; Hydrocarbons, Halogenated -- Chemical Synthesis
    Description: Despite attracting tremendous interest over the last few decades, the field of electrophilic cyclizations is still continuously and rapidly developing. Particularly, metal-free reactions that involve the activation of an alkyne using electrophilic halogen sources are powerful tools in the repertoire of synthetic chemists. This brief overview highlights recent progress in C-C bond-forming halocyclizations allowing for the reaction of alkynes with carbon-nucleophiles. Primarily guided by the type of carbon nucleophile, methods are categorized as the addition of arene, malonate, and olefin nucleophiles.
    Is part of: Organic & biomolecular chemistry, 28 October 2012, Vol.10(40), pp.8041-7
    Identifier: 1477-0539 (E-ISSN); 22987122 Version (PMID)

    • Several versions

    When gold can do what iodine cannot do: A critical comparison

    Hummel, Sara, Kirsch, Stefan F
    Beilstein Journal of Organic Chemistry, 2011, Vol.7, p.847-859 [Peer Reviewed Journal]

    • Several versions

    Synthesis and Chemistry of Organic Geminal Di- and Triazides

    Häring, Andreas P, Kirsch, Stefan F
    Molecules (Basel, Switzerland), 06 November 2015, Vol.20(11), pp.20042-62 [Peer Reviewed Journal]

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    Erratum: "Quantitative time- and frequency-domain analysis of the two-pulse COSY revamped by asymmetic Z-gradient echo detection NMR experiment: theoretical and experimental aspects, time-zero data truncation artifacts, and radiation damping" J. Chem. Phys. 129, 044505 (2008)

    Kirsch, Stefan, Hull, William E
    The Journal of chemical physics, 21 September 2010, Vol.133(11), pp.119902 [Peer Reviewed Journal]
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    Title: Erratum: "Quantitative time- and frequency-domain analysis of the two-pulse COSY revamped by asymmetic Z-gradient echo detection NMR experiment: theoretical and experimental aspects, time-zero data truncation artifacts, and radiation damping" J. Chem. Phys. 129, 044505 (2008)
    Author: Kirsch, Stefan; Hull, William E
    Subject: Artifacts ; Models, Chemical ; Magnetic Resonance Spectroscopy -- Methods
    Is part of: The Journal of chemical physics, 21 September 2010, Vol.133(11), pp.119902
    Identifier: 1089-7690 (E-ISSN); 20866160 Version (PMID); 10.1063/1.3478222 (DOI)

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    Two Kinds of Wrong: On the Context Element of Crimes against Humanity

    Kirsch, Stefan
    Leiden Journal of International Law, 2009, Vol.22(3), pp.525-541 [Peer Reviewed Journal]
    Cambridge University Press
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    Title: Two Kinds of Wrong: On the Context Element of Crimes against Humanity
    Author: Kirsch, Stefan
    Scale: 2009
    Subject: Context Element; Crimes Against Humanity; Jurisdiction; Principle Of Blameworthiness; Widespread Or Systematic Attack
    Description: Abstract It can be shown that – as with the tie between crimes against humanity and the perpetration of other international crimes in the Charter of the International Military Tribunal in Nuremberg – the context element of the crimes against humanity as set out in the Rome Statute is based on the international law principle of non-interference in the affairs of a foreign country, and only serves to justify ‘international’ jurisdiction in respect of crimes which are typically already punishable pursuant to the lex loci commissii . As a consequence, the feature of a ‘widespread or systematic attack directed against any civilian population’ is not an aggravating circumstance in respect of the material facts of the case that define the wrong of the act ( Unrecht ) or the offender's blameworthiness ( Schuld ), but a jurisdictional element which is a mere precondition for prosecution only.
    Former: 200909
    Frequency: 200909
    Is part of: Leiden Journal of International Law, 2009, Vol.22(3), pp.525-541
    Identifier: 0922-1565 (ISSN); 1478-9698 (E-ISSN); 10.1017/S0922156509990070 (DOI)

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    A new method for the synthesis of Z-enediones via IBX-mediated oxidative rearrangement of 2-alkynyl alcohol systems

    Crone, Benedikt, Kirsch, Stefan F
    Chemical communications (Cambridge, England), 21 February 2006(7), pp.764-6 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: A new method for the synthesis of Z-enediones via IBX-mediated oxidative rearrangement of 2-alkynyl alcohol systems
    Author: Crone, Benedikt; Kirsch, Stefan F
    Description: o-Iodoxybenzoic acid (IBX) was found to mediate the conversion of alpha-alkynyl alcohols into Z-enediones under notably mild conditions via a novel rearrangement mechanism (33-65% yield, 13 examples).
    Is part of: Chemical communications (Cambridge, England), 21 February 2006(7), pp.764-6
    Identifier: 1359-7345 (ISSN); 16465333 Version (PMID)

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    Total synthesis of (+)-chloriolide

    Haug, Timm T, Kirsch, Stefan F
    Organic & biomolecular chemistry, 07 March 2010, Vol.8(5), pp.991-3 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Total synthesis of (+)-chloriolide
    Author: Haug, Timm T; Kirsch, Stefan F
    Subject: Ascomycota -- Chemistry ; Macrolides -- Chemical Synthesis
    Description: The first total synthesis of (+)-chloriolide, a 12-membered macrolide from Chloridium virescens (var. chlamydosporum), was accomplished in a longest linear sequence of 20 steps from commercial materials in 7% overall yield.
    Is part of: Organic & biomolecular chemistry, 07 March 2010, Vol.8(5), pp.991-3
    Identifier: 1477-0539 (E-ISSN); 20165786 Version (PMID); 10.1039/b925644j (DOI)

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    Synthesis of geminal bis- and tristriazoles: exploration of unconventional azide chemistry

    Erhardt, Hellmuth, Mohr, Fabian, Kirsch, Stefan F
    Chemical communications (Cambridge, England), 11 January 2016, Vol.52(3), pp.545-8 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Synthesis of geminal bis- and tristriazoles: exploration of unconventional azide chemistry
    Author: Erhardt, Hellmuth; Mohr, Fabian; Kirsch, Stefan F
    Subject: Chemistry;
    Description: A range of geminal bis- and tristriazoles are presented. These rare and hardly studied compound classes were easily synthesized using ethyl 2,2-diazido-3-oxobutanoate as the common starting point. Firstly, CuAAC-reaction with an alkyne afforded the corresponding deacetylated bistriazoles. Upon further azidation yielding azidomethylenebistriazoles, a second CuAAC-functionalization then led to the creation of the geminal tristriazole compounds.
    Is part of: Chemical communications (Cambridge, England), 11 January 2016, Vol.52(3), pp.545-8
    Identifier: 1364-548X (E-ISSN); 26536826 Version (PMID); 10.1039/c5cc08163g (DOI)