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    The ALICE Transition Radiation Detector: status and perspectives for Run II

    Klein, Jochen
    arXiv.org, Jan 4, 2016
    © ProQuest LLC All rights reserved, Engineering Database, Publicly Available Content Database, ProQuest Engineering Collection, ProQuest Technology Collection, ProQuest SciTech Collection, Materials Science & Engineering Database, ProQuest Central (new), ProQuest Central Korea, SciTech Premium Collection, Technology Collection, ProQuest Central Essentials, ProQuest One Academic, Engineering Collection (ProQuest)
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    Title: The ALICE Transition Radiation Detector: status and perspectives for Run II
    Author: Klein, Jochen
    Contributor: Klein, Jochen (pacrepositoryorg)
    Subject: Photons ; Radiation Detectors ; Radiators ; Tracking ; Drift ; Charged Particles ; Charged Particles ; Energy Dissipation ; Radiation Detectors ; Shutdowns ; Instrumentation and Detectors
    Description: The ALICE Transition Radiation Detector contributes to the tracking, particle identification, and triggering capabilities of the experiment. It is composed of six layers of multi-wire proportional chambers, each of which is preceded by a radiator and a Xe/CO\(_2\)-filled drift volume. The signal is sampled in timebins of 100~ns over the drift length which allows for the reconstruction of chamber-wise track segments, both online and offline. The particle identification is based on the specific energy loss of charged particles and additional transition radiation photons, the latter being a signature for electrons. The detector is segmented into 18 sectors, of which 13 were installed in Run I. The TRD was included in data taking since the LHC start-up and was successfully used for electron identification and triggering. During the Long Shutdown 1, the detector was completed and now covers the full azimuthal acceptance. Furthermore, the readout and trigger components were upgraded. When data...
    Is part of: arXiv.org, Jan 4, 2016
    Identifier: 2331-8422 (E-ISSN)

    • Several versions

    Dysfunctional Presynaptic M 2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse

    Mohr, Franziska, Krejci, Eric, Zimmermann, Martina, Klein, Jochen
    PLoS ONE, 2015, Vol.10(10) [Peer Reviewed Journal]

    • Several versions

    Intravenous Treatment with a Long-Chain Omega-3 Lipid Emulsion Provides Neuroprotection in a Murine Model of Ischemic Stroke – A Pilot Study

    Berressem, Dirk, Koch, Konrad, Franke, Nicole, Klein, Jochen, Eckert, Gunter P
    PLoS ONE, 2016, Vol.11(11) [Peer Reviewed Journal]

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    Triggering with the ALICE TRD

    Klein, Jochen
    Cornell University
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    Title: Triggering with the ALICE TRD
    Author: Klein, Jochen
    Subject: Nuclear Experiment ; Physics - Instrumentation And Detectors
    Description: We discuss how a level-1 trigger, about 8 us after a hadron-hadron collision, can be derived from the Transition Radiation Detector (TRD) in A Large Ion Collider Experiment (ALICE) at the LHC. Chamber-wise track segments from fast on-detector reconstruction are read out with position, angle and electron likelihood. In the Global Tracking Unit up to 6 tracklets from a particle traversing the detector layers are matched and used for the reconstruction of transverse momentum and electron identification. Such tracks form the basis for versatile and flexible trigger conditions, e.g. single high-pt hadron, single high-pt electron, di-electron (J/Psi, Upsilon) and at least n close high-pt tracks (jet). The need for low-latency on-line reconstruction poses challenges on the detector operation. The calibration for gain (pad-by-pad) and drift velocity must be applied already in the front-end electronics. Due to changes in pressure and gas composition an on-line monitoring and feedback loop for these parameters is required. First experiences on the performance were gathered from triggering in cosmic and pp runs. Comment: 6 pages, 10 figures
    Identifier: 1112.5110 (ARXIV ID)

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    Triggering with the ALICE TRD

    Klein, Jochen
    arXiv.org, Dec 21, 2011
    © ProQuest LLC All rights reserved, Engineering Database, Publicly Available Content Database, ProQuest Engineering Collection, ProQuest Technology Collection, ProQuest SciTech Collection, Materials Science & Engineering Database, ProQuest Central (new), ProQuest Central Korea, SciTech Premium Collection, Technology Collection, ProQuest Central Essentials, ProQuest One Academic, Engineering Collection (ProQuest)
    Available
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    Title: Triggering with the ALICE TRD
    Author: Klein, Jochen
    Contributor: Klein, Jochen (pacrepositoryorg)
    Subject: Electrons ; Gas Composition ; Large Hadron Collider ; Transverse Momentum ; Accident Reconstruction ; Sensors ; Radiation Detectors ; Feedback Loops ; Instrumentation and Detectors
    Description: We discuss how a level-1 trigger, about 8 us after a hadron-hadron collision, can be derived from the Transition Radiation Detector (TRD) in A Large Ion Collider Experiment (ALICE) at the LHC. Chamber-wise track segments from fast on-detector reconstruction are read out with position, angle and electron likelihood. In the Global Tracking Unit up to 6 tracklets from a particle traversing the detector layers are matched and used for the reconstruction of transverse momentum and electron identification. Such tracks form the basis for versatile and flexible trigger conditions, e.g. single high-pt hadron, single high-pt electron, di-electron (J/Psi, Upsilon) and at least n close high-pt tracks (jet). The need for low-latency on-line reconstruction poses challenges on the detector operation. The calibration for gain (pad-by-pad) and drift velocity must be applied already in the front-end electronics. Due to changes in pressure and gas composition an on-line monitoring and feedback loop for these...
    Is part of: arXiv.org, Dec 21, 2011
    Identifier: 2331-8422 (E-ISSN)

    • Article
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    Title: The ALICE Transition Radiation Detector: status and perspectives for Run II
    Author: Klein, Jochen
    Subject: Physics - Instrumentation And Detectors ; Nuclear Experiment
    Description: The ALICE Transition Radiation Detector contributes to the tracking, particle identification, and triggering capabilities of the experiment. It is composed of six layers of multi-wire proportional chambers, each of which is preceded by a radiator and a Xe/CO$_2$-filled drift volume. The signal is sampled in timebins of 100~ns over the drift length which allows for the reconstruction of chamber-wise track segments, both online and offline. The particle identification is based on the specific energy loss of charged particles and additional transition radiation photons, the latter being a signature for electrons. The detector is segmented into 18 sectors, of which 13 were installed in Run I. The TRD was included in data taking since the LHC start-up and was successfully used for electron identification and triggering. During the Long Shutdown 1, the detector was completed and now covers the full azimuthal acceptance. Furthermore, the readout and trigger components were upgraded. When data taking was started for \runii{}, their performance fulfilled the expectations.
    Identifier: 1601.00493 (ARXIV ID)

    • Several versions

    Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes

    Deckmann, Klaus, Filipski, Katharina, Krasteva-Christ, Gabriela, Fronius, Martin, Althaus, Mike, Rafiq, Amir, Papadakis, Tamara, Renno, Liane, Jurastow, Innokentij, Wessels, Lars, Wolff, Miriam, Schütz, Burkhard, Weihe, Eberhard, Chubanov, Vladimir, Gudermann, Thomas, Klein, Jochen, Bschleipfer, Thomas, Kummer, Wolfgang
    Proceedings of the National Academy of Sciences of the United States of America, 03 June 2014, Vol.111(22), pp.8287-92 [Peer Reviewed Journal]

    • Several versions

    Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release

    Hecker, Andreas, Küllmar, Mira, Wilker, Sigrid, Richter, Katrin, Zakrzewicz, Anna, Atanasova, Srebrena, Mathes, Verena, Timm, Thomas, Lerner, Sabrina, Klein, Jochen, Kaufmann, Andreas, Bauer, Stefan, Padberg, Winfried, Kummer, Wolfgang, Janciauskiene, Sabina, Fronius, Martin, Schweda, Elke K H, Lochnit, Günter
    Journal of immunology (Baltimore, Md. : 1950), 01 September 2015, Vol.195(5), pp.2325-34 [Peer Reviewed Journal]

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    Neurotransmitters and energy metabolites in amyloid-bearing APP(SWE)xPSEN1dE9 Mouse Brain

    Hartmann, Joachim, Kiewert, Cornelia, Klein, Jochen
    The Journal of pharmacology and experimental therapeutics, February 2010, Vol.332(2), pp.364-70 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Neurotransmitters and energy metabolites in amyloid-bearing APP(SWE)xPSEN1dE9 Mouse Brain
    Author: Hartmann, Joachim; Kiewert, Cornelia; Klein, Jochen
    Subject: Energy Metabolism ; Amyloid -- Genetics ; Brain -- Metabolism ; Neurotransmitter Agents -- Metabolism
    Description: Alzheimer's disease is characterized by amyloid peptide formation and deposition, neurofibrillary tangles, synaptic loss and central cholinergic dysfunction, dysfunction of energy metabolism, and dementia; however, the interactions between these hallmarks remain poorly defined. We studied a well characterized mouse model of amyloid deposition, the doubly transgenic APP(SWE)xPSEN1dE9 mouse. At 10 to 14 months of age, these mice had high levels of amyloid peptides (6.6 microg/g wet weight) and widespread amyloid plaques. Extracellular levels of acetylcholine (ACh) were determined by microdialysis in the hippocampus and were comparable with nontransgenic mice from the same colony. In the open field, both mouse strains responded with a 3-fold increase of hippocampal ACh release. Exploratory behavior of the transgenic mice appeared normal. Infusion of scopolamine evoked 5- to 6-fold increases of ACh levels in both mouse strains. High-affinity choline uptake and cholinesterase activities were...
    Is part of: The Journal of pharmacology and experimental therapeutics, February 2010, Vol.332(2), pp.364-70
    Identifier: 1521-0103 (E-ISSN); 19846589 Version (PMID); 10.1124/jpet.109.161091 (DOI)

    • Several versions

    Ginkgo extract EGb761 confers neuroprotection by reduction of glutamate release in ischemic brain

    Mdzinarishvili, Alexander, Sumbria, Rachita, Lang, Dorothee, Klein, Jochen
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2012, Vol.15(1), pp.94-102 [Peer Reviewed Journal]