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    142 The Immune Response Against Respiratory Pathogens in Patients with Chronic Rhinosinusitis/Nasal Polyps and Asthma with or without Sensitivity to Aspirin

    Olszewska-Ziąber, Agnieszka, Jarzębska, Marzanna, Kowalski, Marek L
    The World Allergy Organization Journal, 2012, Vol.5(Suppl 2), p.S64-S64 [Peer Reviewed Journal]
    U.S. National Library of Medicine (NIH/NLM)
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    Title: 142 The Immune Response Against Respiratory Pathogens in Patients with Chronic Rhinosinusitis/Nasal Polyps and Asthma with or without Sensitivity to Aspirin
    Author: Olszewska-Ziąber, Agnieszka; Jarzębska, Marzanna; Kowalski, Marek L
    Subject: Abstracts Of The Xxii World Allergy Congress ; Oral Abstract Session
    Description: Background Viral and bacterial infections can modulate the ongoing inflammation in both upper and lower airways of patients with chronic rhinosinusitis with nasal polyps (CRS/NP) and asthma. It was not clear if the protective immune response to pathogens may differ depending on the disease severity. Object: To compare serum IgG immune response against respiratory pathogens in patients with chronic airway disease (CRS/NP and asthma) with and without sensitivity to aspirin, and to refer the sensitization to severity of chronic rhinosinusitis. Methods We recruited 73 patients with CRS/NP and asthma with (43 patients) and without (30 patients) hypersensitivity to aspirin. The extent of mucosal hypertrophy in paranasal sinuses was assessed by CT scans and the sense of smell was valuated with “sniffing smell” test. Serum IgG immunoglobulin levels against respiratory pathogens: Respiratory Syncytial Virus (RSV), Adenowirus (ADV), Parainfluenza virus (PIV) and Mycoplasma pneumoniae were determined by ELISA. Results Patients with ASA-hypersensitivity had history of significantly more nasal polypectomies ( P = 0.002), lower smell test score ( P = 0.03) and higher mean paranasal CT score ( P = 0.03) as compared to ASA-tolerant patients, reflecting higher severity of the upper airway disease. The percentage of positive serological testing to respiratory pathogens was very high in the whole group of patients with CRS/NP and asthma (RSV, 95.8%; ADV, 95.9%; PIV, 84.9% and Mycoplasma pneumonieae , 100% patients) without any difference between ASA-sensitive and ASA-tolerant subjects. Patients with ASA-sensitivity had significantly lower concentrations of PIV- specific IgG (mean 188.67 ± 34.46 U/mL versus 207.56 ± 30.036 U/mL; P < 0.04) as compared to ASA-tolerant subjects. There was a significant trend ( P < 0.048) for lower PIV–specific IgG concentrations with increased number of polypectomies. No correlation of IgG immunoglobulin concentrations for other pathogens with the number of polypectomies, paranasal sinuses CT score or presences of smell were observed. Conclusions Patients with CRS/NP and asthma had high frequency of IgG immunoglobulin against common respiratory pathogens. Serum IgG immune response to paramyxoviruses may be related to the recurrence of nasal polyps and the presence of aspirin sensitivity.
    Is part of: The World Allergy Organization Journal, 2012, Vol.5(Suppl 2), p.S64-S64
    Identifier: 1939-4551 (E-ISSN); 10.1097/01.WOX.0000411887.21654.e0 (DOI); 3512738 (PMCID)

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    Suche nach astrophysikalischen Neutrinos am Südpol

    Kowalski, Marek
    Jahrbuch der Göttinger Akademie der Wissenschaften, 2011, Vol.2010(2011), pp.169-177 [Peer Reviewed Journal]
    Walter de Gruyter GmbH
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    Title: Suche nach astrophysikalischen Neutrinos am Südpol
    Author: Kowalski, Marek
    Publisher: DE GRUYTER
    Is part of: Jahrbuch der Göttinger Akademie der Wissenschaften, 2011, Vol.2010(2011), pp.169-177
    Identifier: 0373-9767 (ISSN); 1868-9191 (E-ISSN); 10.1515/9783110236774.169 (DOI)

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    Oral and Nasal Steroids for Nasal Polyps

    Kowalski, Marek
    Current Allergy and Asthma Reports, 2011, Vol.11(3), pp.187-188 [Peer Reviewed Journal]

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    Status of High-Energy Neutrino Astronomy

    Kowalski, Marek
    arXiv.org, Nov 17, 2014 [Peer Reviewed Journal]

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    Medical Therapy in Chronic Rhinosinusitis

    Kowalski, Marek
    Current Allergy and Asthma Reports, 2010, Vol.10(3), pp.153-154 [Peer Reviewed Journal]

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    Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa

    Byfield, Fitzroy J, Kowalski, Marek, Cruz, Katrina, Leszczyńska, Katarzyna, Namiot, Andrzej, Savage, Paul B, Bucki, Robert, Janmey, Paul A
    Journal of immunology (Baltimore, Md. : 1950), 15 December 2011, Vol.187(12), pp.6402-9 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa
    Author: Byfield, Fitzroy J; Kowalski, Marek; Cruz, Katrina; Leszczyńska, Katarzyna; Namiot, Andrzej; Savage, Paul B; Bucki, Robert; Janmey, Paul A
    Subject: Antimicrobial Cationic Peptides -- Physiology ; Cathelicidins -- Physiology ; Cell Membrane Permeability -- Immunology ; Cell Migration Inhibition -- Immunology ; Lung -- Immunology ; Pseudomonas Aeruginosa -- Pathogenicity ; Respiratory Mucosa -- Immunology
    Description: In addition to its antibacterial activity, the cathelicidin-derived LL-37 peptide induces multiple immunomodulatory effects on host cells. Atomic force microscopy, F-actin staining with phalloidin, passage of FITC-conjugated dextran through a monolayer of lung epithelial cells, and assessment of bacterial outgrowth from cells subjected to Pseudomonas aeruginosa infection were used to determine LL-37's effect on epithelial cell mechanical properties, permeability, and bacteria uptake. A concentration-dependent increase in stiffness and F-actin content in the cortical region of A549 cells and primary human lung epithelial cells was observed after treatment with LL-37 (0.5-5 μM), sphingosine 1-phosphate (1 μM), or LPS (1 μg/ml) or infection with PAO1 bacteria. Other cationic peptides, such as RK-31, KR-20, or WLBU2, and the antibacterial cationic steroid CSA-13 did not reproduce the effect of LL-37. A549 cell pretreatment with WRW4, an antagonist of the transmembrane formyl peptide receptor-like...
    Is part of: Journal of immunology (Baltimore, Md. : 1950), 15 December 2011, Vol.187(12), pp.6402-9
    Identifier: 1550-6606 (E-ISSN); 22095714 Version (PMID); 10.4049/jimmunol.1102185 (DOI)

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    The Role of Human Parainfluenza Virus Infections in the Immunopathology of the Respiratory Tract

    Pawełczyk, Malgorzata, Kowalski, Marek
    Current Allergy and Asthma Reports, 2017, Vol.17(3), pp.1-10 [Peer Reviewed Journal]

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    Face Alignment Using K-Cluster Regression Forests With Weighted Splitting

    Kowalski, Marek, Naruniec, Jacek
    arXiv.org, Jun 6, 2017 [Peer Reviewed Journal]

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    Deep Alignment Network: A convolutional neural network for robust face alignment

    Kowalski, Marek, Naruniec, Jacek, Trzcinski, Tomasz
    arXiv.org, Aug 10, 2017
    © ProQuest LLC All rights reserved, Engineering Database, Publicly Available Content Database, ProQuest Engineering Collection, ProQuest Technology Collection, ProQuest SciTech Collection, Materials Science & Engineering Database, ProQuest Central (new), ProQuest Central Korea, SciTech Premium Collection, Technology Collection, ProQuest Central Essentials, ProQuest One Academic, Engineering Collection (ProQuest)
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    Title: Deep Alignment Network: A convolutional neural network for robust face alignment
    Author: Kowalski, Marek; Naruniec, Jacek; Trzcinski, Tomasz
    Contributor: Trzcinski, Tomasz (pacrepositoryorg)
    Subject: Neural Networks ; Algorithms ; Images ; Alignment ; Landmarks ; Artificial Neural Networks ; Failure Rates
    Description: In this paper, we propose Deep Alignment Network (DAN), a robust face alignment method based on a deep neural network architecture. DAN consists of multiple stages, where each stage improves the locations of the facial landmarks estimated by the previous stage. Our method uses entire face images at all stages, contrary to the recently proposed face alignment methods that rely on local patches. This is possible thanks to the use of landmark heatmaps which provide visual information about landmark locations estimated at the previous stages of the algorithm. The use of entire face images rather than patches allows DAN to handle face images with large variation in head pose and difficult initializations. An extensive evaluation on two publicly available datasets shows that DAN reduces the state-of-the-art failure rate by up to 70%. Our method has also been submitted for evaluation as part of the Menpo challenge.
    Is part of: arXiv.org, Aug 10, 2017
    Identifier: 2331-8422 (E-ISSN)

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    Eddington bias for cosmic neutrino sources

    Strotjohann, Nora, Kowalski, Marek, Franckowiak, Anna
    arXiv.org, Jan 18, 2019 [Peer Reviewed Journal]