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    • Several versions

    An unusual bifid first metacarpal

    Kumar, Suresh
    Indian Journal of Orthopaedics, 2010, Vol.44(2), p.227-229 [Peer Reviewed Journal]

    • Several versions

    Predominance of Blastocystis sp. Infection among School Children in Peninsular Malaysia

    Nithyamathi, Kalimuthu, Chandramathi, Samudi, Kumar, Suresh
    PLoS ONE, 2016, Vol.11(2) [Peer Reviewed Journal]

    • Several versions

    Granular Formation during Apoptosis in Blastocystis sp. Exposed to Metronidazole (MTZ)

    Devi Balkrishnan Dhurga, Kumar Suresh, Tian Chye Tan
    PloS one, 01 January 2016, Vol.11(7), p.e0155390 [Peer Reviewed Journal]

    • Several versions

    Purification and Characterization of Glutaminase Free Asparaginase from Enterobacter cloacae : In-Vitro Evaluation of Cytotoxic Potential against Human Myeloid Leukemia HL-60 Cells

    Husain, Islam, Sharma, Anjana, Kumar, Suresh, Malik, Fayaz
    PLoS ONE, 2016, Vol.11(2) [Peer Reviewed Journal]

    • Several versions

    Blastocystis sp . in Irritable Bowel Syndrome (IBS) - Detection in Stool Aspirates during Colonoscopy

    Ragavan, Nanthiney Devi, Kumar, Suresh, Chye, Tan Tian, Mahadeva, Sanjiv, Shiaw-Hooi, Ho
    PLoS ONE, 2015, Vol.10(9) [Peer Reviewed Journal]

    • Several versions

    Stress exacerbates infectivity and pathogenicity of Blastocystis hominis: in vitro and in vivo evidences

    Samudi Chandramathi, Kumar Suresh, Sinnadurai Sivanandam, Umah Rani Kuppusamy
    PloS one, 01 January 2014, Vol.9(5), p.e94567 [Peer Reviewed Journal]

    • Several versions

    Primary total elbow arthroplasty

    Kumar, Suresh, Mahanta, Sunayan
    Indian Journal of Orthopaedics, 2013, Vol.47(6), p.608-614 [Peer Reviewed Journal]

    • Several versions

    Psychiatric morbidity, pain perception, and functional status of chronic pain patients in palliative care

    Rajmohan, V, Kumar, Suresh
    Indian Journal of Palliative Care, 2013, Vol.19(3), p.146-151 [Peer Reviewed Journal]

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    A LITERATURE REVIEW ON LOAD BALANCING MECHANISMS IN CLOUD COMPUTING

    Kumar, Suresh
    International Journal of Advanced Research in Computer Science, Jan 2018, Vol.9(1) [Peer Reviewed Journal]
    © ProQuest LLC All rights reserved, Computing Database (Alumni edition), ProQuest Computing, Advanced Technologies & Aerospace Database, ProQuest Computer Science Journals, Publicly Available Content Database, Advanced Technologies Database with Aerospace, Technology Research Database, ProQuest Central, ProQuest Advanced Technologies & Aerospace Collection, ProQuest Technology Collection, ProQuest Computer Science Collection, ProQuest SciTech Collection, Computer and Information Systems Abstracts, ProQuest Central (new), ProQuest Central K-12, ProQuest Central Korea, SciTech Premium Collection, Technology Collection, ProQuest Central Essentials, ProQuest One Academic, Advanced Technologies & Aerospace Index (ProQuest)
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    Title: A LITERATURE REVIEW ON LOAD BALANCING MECHANISMS IN CLOUD COMPUTING
    Author: Kumar, Suresh
    Subject: Workload ; Algorithms ; Performance Enhancement ; Algorithms ; Workloads ; Cloud Computing ; Servers ; Cloud Computing ; Load Balancing ; New Technology ; End Users ; Literature Reviews
    Description: Cloud computing is a new technology now a days for providing different kind of services to the end users. It focuses mainly the dynamic services using very large scalable and virtualized resources over the Internet. The allocation of the group of resources may start a problem of availability of these resources and distributing the workload of all the VMs among themselves called as load balancing. Load balancing is a main challenge in cloud environment. It helps to distribute the dynamic workload across multiple nodes to ensure that no single node is overloaded. It helps in proper utilization of resources .It also improves the performance of the system. Load balancing is the process of finding overloaded nodes and then transferring the extra load to other nodes. Due to novelty of cloud computing field, there is no many standard load balancing algorithm used in cloud environment. Hence efficient utilization of resources must be important and for that load balancing plays a major role to get...
    Is part of: International Journal of Advanced Research in Computer Science, Jan 2018, Vol.9(1)
    Identifier: 09765697 (E-ISSN)

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    Computational identification and binding analysis of orphan human cytochrome P450 4X1 enzyme with substrates

    Kumar, Suresh
    BMC research notes, 17 January 2015, Vol.8, pp.9 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Computational identification and binding analysis of orphan human cytochrome P450 4X1 enzyme with substrates
    Author: Kumar, Suresh
    Subject: Computational Biology -- Methods ; Cytochrome P-450 Enzyme System -- Chemistry
    Description: Cytochrome P450s (CYPs) are important heme-containing proteins, well known for their monooxygenase reaction. The human cytochrome P450 4X1 (CYP4X1) is categorized as "orphan" CYP because of its unknown function. In recent studies it is found that this enzyme is expressed in neurovascular functions of the brain. Also, various studies have found the expression and activity of orphan human cytochrome P450 4X1 in cancer. It is found to be a potential drug target for cancer therapy. However, three-dimensional structure, the active site topology and substrate specificity of CYP4X1 remain unclear. In the present study, the three-dimensional structure of orphan human cytochrome P450 4X1 was generated by homology modeling using Modeller 9v8. The generated structure was accessed for geometrical errors and energy stability using PROCHECK, VERFIY 3D and PROSA. A molecular docking analysis was carried out against substrates arachidonic acid and anandamide and the docked substrates were predicted for drug-likeness, ADME-Tox parameters and biological spectrum activity. The three-dimensional model of orphan human cytochrome P450 4X1 was generated and assessed with various structural validation programmes. Docking of orphan human cytochrome P450 4X1 with arachidonic acid revealed that TYR 112, ALA 126, ILE 222, ILE 223, THR 312, LEU 315, ALA 316, ASP 319, THR 320, PHE 491 and ILE 492 residues were actively participating in the interaction, while docking of CYP4X1 with anandamide showed that TYR 112, GLN 114, PRO 118, ALA 126, ILE 222, ILE 223, SER 251, LEU 315, ALA 316 and PHE 491 key residues were involved in strong interaction. From this study, several key residues were identified to be responsible for the binding of arachidonic acid and anandamide with orphan human cytochrome P450 4X1. Both substrates obeyed Lipinski rule of five in drug-likeness test and biological spectrum prediction showed anticarcinogenic activity. Compared to anandamide, arachidonic acid showed strong interaction with cytochrome P450 4X1 and also less health effect in certain human system in ADME-Tox prediction. These findings provide useful information on the biological role and structure-based drug design of orphan human cytochrome P450 4X1.
    Is part of: BMC research notes, 17 January 2015, Vol.8, pp.9
    Identifier: 1756-0500 (E-ISSN); 25595103 Version (PMID); 10.1186/s13104-015-0976-4 (DOI)