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    Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment

    Sun, Tingting, Yang, Xiaomei, Wang, Wei, Zhang, Xiaojuan, Xu, Quanbin, Zhu, Songcheng, Kuchta, Robert, Chen, Guanjun, Liu, Xuedong
    The Journal of biological chemistry, 03 December 2010, Vol.285(49), pp.38730-9 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment
    Author: Sun, Tingting; Yang, Xiaomei; Wang, Wei; Zhang, Xiaojuan; Xu, Quanbin; Zhu, Songcheng; Kuchta, Robert; Chen, Guanjun; Liu, Xuedong
    Subject: Cell Cycle Proteins -- Metabolism ; G1 Phase -- Physiology ; Mitosis -- Physiology ; Protein-Serine-Threonine Kinases -- Metabolism ; Spindle Apparatus -- Metabolism
    Description: Mps1 is a protein kinase that regulates normal mitotic progression and the spindle checkpoint in response to spindle damage. The levels of Mps1 are relatively low in cells during interphase but elevated in mitosis or upon activation of the spindle checkpoint, although the dynamic range of Mps1 expression and the Mps1 catalytic mechanism have not been carefully characterized. Our recent structural studies of the Mps1 kinase domain revealed that the carboxyl-terminal tail region of Mps1 is unstructured, raising the question of whether this region has any functional role in Mps1 catalysis. Here we first determined the cellular abundance of Mps1 during cell cycle progression and found that Mps1 levels vary between 60,000 per cell in early G(1) and 110,000 per cell during mitosis. We studied phosphorylation of a number of Mps1 substrates in vitro and in culture cells. Unexpectedly, we found that the unstructured carboxyl-terminal region of Mps1 plays an essential role in substrate recruitment....
    Is part of: The Journal of biological chemistry, 03 December 2010, Vol.285(49), pp.38730-9
    Identifier: 1083-351X (E-ISSN); 20884615 Version (PMID); 10.1074/jbc.M110.177642 (DOI)

    • Several versions

    Copper Oxide Nanoparticles Induce Autophagic Cell Death in A549 Cells (CuO Nanoparticles Induce Autophagic Cell Death)

    Sun, Tingting, Yan, Yiwu, Zhao, Yan, Guo, Feng, Jiang, Chengyu
    2012, Vol.7(8), p.e43442 [Peer Reviewed Journal]

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    Artificial reefs for sea cucumber aquaculture confirmed as settlement substrates of the moon jellyfish Aurelia coerulea

    Dong, Zhijun, Wang, Lei, Sun, Tingting, Liu, Qingqing, Sun, Youfang
    Hydrobiologia, 2018, Vol.818(1), pp.223-234 [Peer Reviewed Journal]
    Springer Science & Business Media B.V.
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    Title: Artificial reefs for sea cucumber aquaculture confirmed as settlement substrates of the moon jellyfish Aurelia coerulea
    Author: Dong, Zhijun; Wang, Lei; Sun, Tingting; Liu, Qingqing; Sun, Youfang
    Subject: Jellyfish blooms ; Ephyrae ; Polyps ; Sea cucumber ; Aurelia coerulea
    Description: In coastal areas with a high intensity of human activities, expansion of artificial structures may enhance Aurelia spp. blooms because these constructions may provide additional substrates for the settlement and proliferation of the polyps. In the present study, the possible occurrence and distribution of Aurelia coerulea ephyrae and polyps were investigated in sea cucumber ( Apostichopus   japonicus ) culture ponds that contain huge amounts of artificial structures. Our results showed that A. coerulea ephyrae were widely distributed in the A.   japonicus culture ponds along the Bohai and Yellow Seas. Furthermore, underwater photography revealed that polyps of A. coerulea mainly occurred on the undersides of the artificial reefs made by plastic sunshade nets, tiles and substrate cages. The artificial reefs may decrease the time A. coerulea planulae spend settling, provide more hidden, calm and shady places for the settlement and proliferation of A. coerulea planulae, and thus were suitable substrates for the moon jellyfish A. coerulea . Our study suggests that the A.   japonicus culture ponds may act as nursery grounds for the jellyfish A. coerulea and may potentially enhance the blooms of this species in the coastal waters along the Bohai and Yellow Seas.
    Is part of: Hydrobiologia, 2018, Vol.818(1), pp.223-234
    Identifier: 0018-8158 (ISSN); 1573-5117 (E-ISSN); 10.1007/s10750-018-3615-y (DOI)

    • Several versions

    Effect of tea saponin on ephyrae and polyps of the moon jellyfish Aurelia sp.1

    Dong, Zhijun, Sun, Tingting, Liang, Likun, Wang, Lei
    PLoS ONE, 2017, Vol.12(8) [Peer Reviewed Journal]

    • Several versions

    microRNA Profiling of Amniotic Fluid: Evidence of Synergy of microRNAs in Fetal Development

    Sun, Tingting, Li, Weiyun, Li, Tianpeng, Ling, Shucai
    PLoS ONE, 2016, Vol.11(5) [Peer Reviewed Journal]

    • Several versions

    Microbial diversity and composition in different gut locations of hyperlipidemic mice receiving krill oil

    Lu, Chenyang, Sun, Tingting, Li, Yanyan, Zhang, Dijun, Zhou, Jun, Su, Xiurong
    Applied Microbiology and Biotechnology, 2018, Vol.102(1), pp.355-366 [Peer Reviewed Journal]

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    Transforming growth factor-β-induced long noncoding RNA promotes liver cancer metastasis via RNA-RNA crosstalk

    Sun, Tingting, Wong, Nathalie
    Hepatology (Baltimore, Md.), February 2015, Vol.61(2), pp.722-4 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: Transforming growth factor-β-induced long noncoding RNA promotes liver cancer metastasis via RNA-RNA crosstalk
    Author: Sun, Tingting; Wong, Nathalie
    Subject: Carcinoma, Hepatocellular -- Genetics ; Liver Neoplasms -- Genetics ; RNA, Long Noncoding -- Genetics ; Transforming Growth Factor Beta -- Metabolism
    Description: To establish the culture system of fetal bovine intestinal epithelial stem cells (IESCs) in vitro, identify specific markers of the cell lines and analyze the differentiation potential into hepatocyte-like cells. IESCs were isolated from the 3- to 5-month fetal bovine intestine by the digestion of collagenase I, and cultured in the DMEM/F12 medium. The cell morphology was observed, and the proliferation ability and multiple differentiation potential were demonstrated by subculturing and its growth curve. The mRNA expressions of the surface markers Bmi1, Hes1, Lgr5 and cytokeratin 19 (CK19) were determined by reverse transcription PCR (RT-PCR), and the protein levels of Bmi1, LGR5 and CK19 were detected by immunofluorescence cytochemistry. Under the induction of fibroblast growth factor 4 (FGF-4) and hepatocyte growth factor (HGF), the cell differentiation into hepatocyte-like cells was assayed by the glycogen staining and RT-PCR. IESCs cultured in vitro expressed Bmi1, Hes1, Lgr5 and CK19 mRNAs, and CK19, Bmi1 and LGR5 proteins. The differentiated cells were positively stained by glycogen, and RT-PCR showed that the cells expressed α-fetoprotein (AFP) and albumin (ALB) mRNAs. The culture system of IESCs in vitro is successfully established, and the cells are differentiated into hepatocyte-like cells.
    Is part of: Hepatology (Baltimore, Md.), February 2015, Vol.61(2), pp.722-4
    Identifier: 1527-3350 (E-ISSN); 25380484 Version (PMID); 10.1002/hep.27599 (DOI)

    • Several versions

    The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

    Meerbrey, Kristen L, Hu, Guang, Kessler, Jessica D, Roarty, Kevin, Li, Mamie Z, Fang, Justin E, Herschkowitz, Jason I, Burrows, Anna E, Ciccia, Alberto, Sun, Tingting, Schmitt, Earlene M, Bernardi, Ronald J, Fu, Xiaoyong, Bland, Christopher S, Cooper, Thomas A, Schiff, Rachel, Rosen, Jeffrey M, Westbrook, Thomas F, Elledge, Stephen J
    Proceedings of the National Academy of Sciences of the United States of America, 01 March 2011, Vol.108(9), pp.3665-70 [Peer Reviewed Journal]

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    Preparation, sintering behavior, and expansion performance of ceramsite filter media from dewatered sewage sludge, coal fly ash, and river sediment

    Li, Tianpeng, Sun, Tingting, Li, Dengxin
    Journal of Material Cycles and Waste Management, 2018, Vol.20(1), pp.71-79 [Peer Reviewed Journal]
    Springer Science & Business Media B.V.
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    Title: Preparation, sintering behavior, and expansion performance of ceramsite filter media from dewatered sewage sludge, coal fly ash, and river sediment
    Author: Li, Tianpeng; Sun, Tingting; Li, Dengxin
    Subject: Ceramsite filter media ; Sintering behavior ; Dewatered sewage sludge ; Ignition loss ; Expansion performance
    Description: The main aim of this study is to assess the preparation, sintering behavior, and expansion performance of ceramsite filter media (CFM) from dewatered sewage sludge, coal fly ash, and river sediment without using any natural resources. The results showed that the investigated physical properties of lab made CFM met with the China’s industrial standard of CJ/T 299-2008 and the concentration of heavy metals in the lixivium was lower than the threshold of GB 5085.3-2007. During the sintering process, the relationships between ignition loss rate, expansion rate, and sintering temperature could be well described simultaneously by the 3-order polynomial fitting curve, with high correlation coefficient values ( R 2  > 0.999). The fitting curves of the ignition loss rate and expansion rate had one peak and one valley, respectively, and their cut-off point that is the sintering temperatures were the same (700 °C). The whole sintering process could be divided into two stages. The ignition loss rate was gradually increased in both the stages. At the same time, the expansion rate was decreased in the first stage and then increased in the second stage. The significance of this work is to pursue the concept of sustainable development.
    Is part of: Journal of Material Cycles and Waste Management, 2018, Vol.20(1), pp.71-79
    Identifier: 1438-4957 (ISSN); 1611-8227 (E-ISSN); 10.1007/s10163-016-0547-3 (DOI)

    • Several versions

    Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA

    Jin, Xin, Sun, Tingting, Zhao, Chuanke, Zheng, Yongxiang, Zhang, Yufan, Cai, Weijing, He, Qiuchen, Taira, Kaz, Zhang, Lihe, Zhou, Demin
    Nucleic Acids Research, 2012, Vol.40(4), p.1797-1806 [Peer Reviewed Journal]