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    • Several versions

    The Hepatitis B Virus X Protein Inhibits Thymine DNA Glycosylase Initiated Base Excision Repair (Inhibition of BER by the HBV Protein X)

    van de Klundert, Maarten A. A, van Hemert, Formijn J, Zaaijer, Hans L, Kootstra, Neeltje A
    2012, Vol.7(11), p.e48940 [Peer Reviewed Journal]

    • Several versions

    Protein X of Hepatitis B Virus: Origin and Structure Similarity with the Central Domain of DNA Glycosylase (3D-Structure Similarity of HBx with DNA Glycosylase)

    van Hemert, Formijn J, van de Klundert, Maarten A. A, Lukashov, Vladimir V, Kootstra, Neeltje A, Berkhout, Ben, Zaaijer, Hans L
    PLoS ONE, 2011, Vol.6(8), p.e23392 [Peer Reviewed Journal]

    • Several versions

    Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection

    Shevtsov, Maxim, Zhao, Lili, Protzer, Ulrike, Van De Klundert, Maarten A. A
    Viruses, 2017, Vol.9(7) [Peer Reviewed Journal]

    • Several versions

    Hepatitis B Virus Protein X Induces Degradation of Talin-1

    Van De Klundert, Maarten A A, Van Den Biggelaar, Maartje, Kootstra, Neeltje A, Zaaijer, Hans L
    Viruses, 19 October 2016, Vol.8(10) [Peer Reviewed Journal]

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    G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA

    Cobos Jiménez, Viviana, Martinez, Fernando O, Booiman, Thijs, Van Dort, Karel A, Van De Klundert, Maarten A A, Gordon, Siamon, Geijtenbeek, Teunis B H, Kootstra, Neeltje A
    Virology, December 2015, Vol.486, pp.94-104 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA
    Author: Cobos Jiménez, Viviana; Martinez, Fernando O; Booiman, Thijs; Van Dort, Karel A; Van De Klundert, Maarten A A; Gordon, Siamon; Geijtenbeek, Teunis B H; Kootstra, Neeltje A
    Subject: Activated T-Cells ; G3bp1 ; HIV-1 ; Ifngamma ; Macrophage Activation ; Macrophage Transcriptome Profiles ; Tnfalpha ; Virus Replication ; Carrier Proteins -- Metabolism ; HIV Infections -- Enzymology ; HIV-1 -- Physiology ; Macrophages -- Metabolism ; RNA, Viral -- Metabolism ; T-Lymphocytes -- Metabolism
    Description: HIV-1 exploits the cellular machinery for replication and therefore several interactions with cellular factors take place, some of which are yet unknown. We identified GTPase-activating protein-(SH3 domain)-binding protein 1 (G3BP1) as a cellular factor that restricts HIV-1, by analyzing transcriptome profiles of in vitro-cytokine-activated macrophages that are non-permissive to HIV-1 replication. Silencing of G3BP1 by RNA interference resulted in increased HIV-1 replication in primary T-cells and macrophages, but did not affect replication of other retroviruses. G3BP1 specifically interacted with HIV-1 RNA in the cytoplasm, suggesting that it sequesters viral transcripts, thus preventing translation or packaging. G3BP1 was highly expressed in resting naïve or memory T-cells from healthy donors and HIV-1 infected patients, but significantly lower in IL-2-activated T-cells. These results strongly suggest that G3BP1 captures HIV-1 RNA transcripts and thereby restricts mRNA translation, viral...
    Is part of: Virology, December 2015, Vol.486, pp.94-104
    Identifier: 1096-0341 (E-ISSN); 26432022 Version (PMID); 10.1016/j.virol.2015.09.007 (DOI)