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Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding
Koeberle, Andreas, Shindou, Hideo, Koeberle, Solveigh C, Laufer, Stefan A, Shimizu, Takao, Werz, Oliver
Proceedings of the National Academy of Sciences of the United States of America, 12 February 2013, Vol.110(7), pp.2546-51 [Peer Reviewed Journal]

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12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3
Blazevic, Tina, Schwaiberger, Andrea V, Schreiner, Cornelia E, Schachner, Daniel, Schaible, Anja M, Grojer, Christoph S, Atanasov, Atanas G, Werz, Oliver, Dirsch, Verena M, Heiss, Elke H
The Journal of biological chemistry, 06 December 2013, Vol.288(49), pp.35592-603 [Peer Reviewed Journal]

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Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor y (PPARy) in the Conversion of White-to-brown Adipocytes
García - Alonso, Verónica, López Vicario, Cristina, Titos Rodríguez, Esther, Morán - Salvador, Eva, González Périz, Ana, Rius, Bibiana, Párrizas, Marcelina, Werz, Oliver, Arroyo, Vicente, Clària I Enrich, Joan
https://doi.org/10.1074/jbc.M113.468603 [Peer Reviewed Journal]
Universitat de Barcelona

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Title: Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor y (PPARy) in the Conversion of White-to-brown Adipocytes
Author: García - Alonso, Verónica; López Vicario, Cristina; Titos Rodríguez, Esther; Morán - Salvador, Eva; González Périz, Ana; Rius, Bibiana; Párrizas, Marcelina; Werz, Oliver; Arroyo, Vicente; Clària I Enrich, Joan
Subject: Teixit Adipós ; Prostaglandines ; Trastorns Del Metabolisme ; Regulació Del Metabolisme ; Adipose Tissues ; Prostaglandins ; Disorders Of Metabolism ; Metabolic Regulation
Description: Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor and a master regulator of adipogenesis. Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme that couples with cyclooxygenase-2 for the biosynthesis of PGE2. In this study we demonstrate the existence of a coordinate functional interaction between PPARγ and mPGES-1 in controlling the process of pre-adipocyte differentiation in white adipose tissue (WAT). Adipocyte-specific PPARγ knock-out mice carrying an aP2 promoter-driven Cre recombinase transgene showed a blunted response to the adipogenic effects of a high fat diet. Pre-adipocytes from these knock-out mice showed loss of PPARγ and were resistant to rosiglitazone-induced WAT differentiation. In parallel, WAT from these mice showed increased expression of uncoupling protein 1, a mitochondrial enzyme that dissipates chemical energy as heat. Adipose tissue from mice lacking PPARγ also showed mPGES-1 up-regulation and increased...
Is part of: https://doi.org/10.1074/jbc.M113.468603
Identifier: 0021-9258 (ISSN)

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Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1)
Waltenberger, Birgit, Wiechmann, Katja, Bauer, Julia, Markt, Patrick, Noha, Stefan M, Wolber, Gerhard, Rollinger, Judith M, Werz, Oliver, Schuster, Daniela, Stuppner, Hermann
Journal of medicinal chemistry, 12 May 2011, Vol.54(9), pp.3163-3174 [Peer Reviewed Journal]
ACS Publications (American Chemical Society)

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Title: Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1)
Author: Waltenberger, Birgit; Wiechmann, Katja; Bauer, Julia; Markt, Patrick; Noha, Stefan M; Wolber, Gerhard; Rollinger, Judith M; Werz, Oliver; Schuster, Daniela; Stuppner, Hermann
Subject: Pharmacy, Therapeutics, & Pharmacology ; Chemistry
Description: Microsomal prostaglandin E2 synthase-1 (mPGES-1) catalyzes prostaglandin E2 formation and is considered as a potential anti-inflammatory pharmacological target. To identify novel chemical scaffolds active on this enzyme, two pharmacophore models for acidic mPGES-1 inhibitors were developed and theoretically validated using information on mPGES-1 inhibitors from literature. The models were used to screen chemical databases supplied from the National Cancer Institute (NCI) and the Specs. Out of 29 compounds selected for biological evaluation, nine chemically diverse compounds caused concentration-dependent inhibition of mPGES-1 activity in a cell-free assay with IC50 values between 0.4 and 7.9 μM, respectively. Further pharmacological characterization revealed that also 5-lipoxygenase (5-LO) was inhibited by most of these active compounds in cell-free and cell-based assays with IC50 values in the low micromolar range. Together, nine novel chemical scaffolds inhibiting mPGES-1 are...
Is part of: Journal of medicinal chemistry, 12 May 2011, Vol.54(9), pp.3163-3174
Identifier: 0022-2623 (ISSN); 1520-4804 (E-ISSN); 10.1021/jm101309g (DOI)

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A Metabolic Probe-Enabled Strategy Reveals Uptake and Protein Targets of Polyunsaturated Aldehydes in the Diatom Phaeodactylum tricornutum
Wolfram, Stefanie, Wielsch, Natalie, Hupfer, Yvonne, Mönch, Bettina, Lu-Walther, Hui-Wen, Heintzmann, Rainer, Werz, Oliver, Svatoš, Aleš, Pohnert, Georg
PLoS One, Oct 2015, Vol.10(10), p.e0140927 [Peer Reviewed Journal]

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Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes
García-Alonso, Verónica, López-Vicario, Cristina, Titos, Esther, Morán-Salvador, Eva, González-Périz, Ana, Rius, Bibiana, Párrizas, Marcelina, Werz, Oliver, Arroyo, Vicente, Clària, Joan
The Journal of biological chemistry, 27 September 2013, Vol.288(39), pp.28230-42 [Peer Reviewed Journal]
MEDLINE/PubMed (U.S. National Library of Medicine)

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Title: Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes
Author: García-Alonso, Verónica; López-Vicario, Cristina; Titos, Esther; Morán-Salvador, Eva; González-Périz, Ana; Rius, Bibiana; Párrizas, Marcelina; Werz, Oliver; Arroyo, Vicente; Clària, Joan
Subject: Adipose Tissue ; Beige Adipocytes ; Cyclooxygenase (Cox) Pathway ; Eicosanoid ; Metabolic Diseases ; Pparγ ; Pre-Adipocytes ; Prostaglandins ; Mpges-1 ; Gene Expression Regulation, Enzymologic ; Adipocytes, Brown -- Metabolism ; Adipocytes, White -- Metabolism ; Intramolecular Oxidoreductases -- Metabolism ; Microsomes -- Enzymology ; Ppar Gamma -- Metabolism
Description: Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor and a master regulator of adipogenesis. Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme that couples with cyclooxygenase-2 for the biosynthesis of PGE2. In this study we demonstrate the existence of a coordinate functional interaction between PPARγ and mPGES-1 in controlling the process of pre-adipocyte differentiation in white adipose tissue (WAT). Adipocyte-specific PPARγ knock-out mice carrying an aP2 promoter-driven Cre recombinase transgene showed a blunted response to the adipogenic effects of a high fat diet. Pre-adipocytes from these knock-out mice showed loss of PPARγ and were resistant to rosiglitazone-induced WAT differentiation. In parallel, WAT from these mice showed increased expression of uncoupling protein 1, a mitochondrial enzyme that dissipates chemical energy as heat. Adipose tissue from mice lacking PPARγ also showed mPGES-1 up-regulation and increased...
Is part of: The Journal of biological chemistry, 27 September 2013, Vol.288(39), pp.28230-42
Identifier: 1083-351X (E-ISSN); 23943621 Version (PMID); 10.1074/jbc.M113.468603 (DOI)

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Separation of 5-Lipoxygenase Metabolites Using Cyclodextrin-Modified Microemulsion Electrokinetic Chromatography and Head Column Field-Amplified Sample Stacking
Abromeit, Hans, Werz, Oliver, Scriba, Gerhard
Chromatographia, 2013, Vol.76(17), pp.1187-1192 [Peer Reviewed Journal]
Springer Science & Business Media B.V.

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Title: Separation of 5-Lipoxygenase Metabolites Using Cyclodextrin-Modified Microemulsion Electrokinetic Chromatography and Head Column Field-Amplified Sample Stacking
Author: Abromeit, Hans; Werz, Oliver; Scriba, Gerhard
Subject: Microemulsion electrokinetic chromatography ; Leukotriene ; Eicosatetraenoic acid ; 5-lipoxygenase ; Arachidonic acid
Description: A cyclodextrin-modified microemulsion electrokinetic chromatography method employing head column field-amplified sample stacking was developed for the analysis of arachidonic acid metabolites of the lipoxygenase pathways. The influence of the concentration of boric acid, the surfactant sodium dodecyl sulfate, the co-surfactant 1-butanol and the oil phase octane as well as the pH of the background electrolyte, the separation voltage and the separation temperature was studied. The optimized microemulsion consisting of 20 mM boric acid buffer, pH 9.0, 3.0 % (m/v) sodium dodecyl sulfate, 0.5 % (v/v) octane, 5.0 % (v/v) 1-butanol and 15 mM α-cyclodextrin enabled the separation of 20-hydroxy-leukotriene B 4 , leukotriene B 4 , 6- trans -leukotriene B 4 , 6- trans -12- epi -leukotriene B 4 , 5( S )-hydroxy-6- trans -8,11,14- cis -eicosatetraenoic acid, 12( S )-hydroxy-5,8,14- cis -10- trans -eicosatetraenoic acid, 15( S )-hydroxy-5,8,11- cis -13- trans -eicosatetraenoic acid as well as the internal standard prostaglandin B 1 in
Is part of: Chromatographia, 2013, Vol.76(17), pp.1187-1192
Identifier: 0009-5893 (ISSN); 1612-1112 (E-ISSN); 10.1007/s10337-013-2517-4 (DOI)

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Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct
Golkowski, Martin, Pergola, Carlo, Werz, Oliver, Ziegler, Thomas
Organic & biomolecular chemistry, 21 June 2012, Vol.10(23), pp.4496-9 [Peer Reviewed Journal]
MEDLINE/PubMed (U.S. National Library of Medicine)

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Title: Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct
Author: Golkowski, Martin; Pergola, Carlo; Werz, Oliver; Ziegler, Thomas
Subject: Alkynes -- Chemistry ; Azides -- Chemistry
Description: A photolabile o-nitrobenzyl linker-cyclooctyne conjugate was prepared, immobilized on poly(methacrylate) beads and utilized as a trap for azide-functionalized compounds. These could be released by 365 nm UV light irradiation in high yield and purity. The "reagent-free" and time economic catch and release protocol was deemed useful for chemical proteomics applications.
Is part of: Organic & biomolecular chemistry, 21 June 2012, Vol.10(23), pp.4496-9
Identifier: 1477-0539 (E-ISSN); 22573264 Version (PMID); 10.1039/c2ob25440a (DOI)

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A tiered approach to investigate the mechanism of anti-inflammatory activity of an herbal medicinal product containing a fixed combination of thyme herb and primula root extracts
Seibel, Jan, Wonnemann, Meinolf, Werz, Oliver, Lehner, Martin
Clinical Phytoscience, 2018, Vol.4(1), pp.1-9 [Peer Reviewed Journal]

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Imbricaric Acid and Perlatolic Acid: Multi-Targeting Anti-Inflammatory Depsides from Cetrelia monachorum
Oettl, Sarah K, Gerstmeier, Jana, Khan, Shafaa Y, Wiechmann, Katja, Bauer, Julia, Atanasov, Atanas G, Malainer, Clemens, Awad, Ezzat M, Uhrin, Pavel, Heiss, Helke H, Waltenberger, Birgit, Remias, Daniel, Breuss, Johannes M, Boustie, Joël, Dirsch, Verena M, Stuppner, Hermann, Werz, Oliver, Rollinger, Judith M
PloS one, 09 October 2013, Vol.8(10), p.e76929 [Peer Reviewed Journal]

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4
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»

Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding

12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3

Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor y (PPARy) in the Conversion of White-to-brown Adipocytes

Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1)

A Metabolic Probe-Enabled Strategy Reveals Uptake and Protein Targets of Polyunsaturated Aldehydes in the Diatom Phaeodactylum tricornutum

Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes

Separation of 5-Lipoxygenase Metabolites Using Cyclodextrin-Modified Microemulsion Electrokinetic Chromatography and Head Column Field-Amplified Sample Stacking

Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct

A tiered approach to investigate the mechanism of anti-inflammatory activity of an herbal medicinal product containing a fixed combination of thyme herb and primula root extracts

Imbricaric Acid and Perlatolic Acid: Multi-Targeting Anti-Inflammatory Depsides from Cetrelia monachorum