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    Molecular mechanisms of calcium-sensing receptor-mediated calcium signaling in the modulation of epithelial ion transport and bicarbonate secretion

    Xie, Rui, Dong, Xiao, Wong, Chase, Vallon, Volker, Tang, Bo, Sun, Jun, Yang, Shiming, Dong, Hui
    The Journal of biological chemistry, 12 December 2014, Vol.289(50), pp.34642-53 [Peer Reviewed Journal]
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    Title: Molecular mechanisms of calcium-sensing receptor-mediated calcium signaling in the modulation of epithelial ion transport and bicarbonate secretion
    Author: Xie, Rui; Dong, Xiao; Wong, Chase; Vallon, Volker; Tang, Bo; Sun, Jun; Yang, Shiming; Dong, Hui
    Subject: Bicarbonate ; Calcium ; Calcium Channel ; Calcium Imaging ; Calcium-Sensing Receptor ; Cytosolic Ca2+ Concentrations ; Epithelial Cell ; G Protein-Coupled Receptor (Gpcr) ; Receptor-Op ; Transepithelial Hco3− Secretion ; Calcium Signaling ; Bicarbonates -- Metabolism ; Epithelial Cells -- Cytology ; Receptors, Calcium-Sensing -- Metabolism
    Description: Epithelial ion transport is mainly under the control of intracellular cAMP and Ca(2+) signaling. Although the molecular mechanisms of cAMP-induced epithelial ion secretion are well defined, those induced by Ca(2+) signaling remain poorly understood. Because calcium-sensing receptor (CaSR) activation results in an increase in cytosolic Ca(2+) ([Ca(2+)]cyt) but a decrease in cAMP levels, it is a suitable receptor for elucidating the mechanisms of [Ca(2+)]cyt-mediated epithelial ion transport and duodenal bicarbonate secretion (DBS). CaSR proteins have been detected in mouse duodenal mucosae and human intestinal epithelial cells. Spermine and Gd(3+), two CaSR activators, markedly stimulated DBS without altering duodenal short circuit currents in wild-type mice but did not affect DBS and duodenal short circuit currents in cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice. Clotrimazole, a selective blocker of intermediate conductance Ca(2+)-activated K(+) channels but...
    Is part of: The Journal of biological chemistry, 12 December 2014, Vol.289(50), pp.34642-53
    Identifier: 1083-351X (E-ISSN); 25331955 Version (PMID); 10.1074/jbc.M114.592774 (DOI)

    • Several versions

    Determination of Benefits of Cochlear Implantation in Children with Auditory Neuropathy

    Ji, Fei, Li, Jianan, Hong, Mengdi, Chen, Aiting, Jiao, Qingshan, Sun, Li, Liang, Sichao, Yang, Shiming
    PLoS ONE, 2015, Vol.10(5) [Peer Reviewed Journal]

    • Several versions

    Reduction in Noise-Induced Functional Loss of the Cochleae in Mice with Pre-Existing Cochlear Dysfunction Due to Genetic Interference of Prestin

    Cai, Qunfeng, Wang, Bo, Coling, Donald, Zuo, Jian, Fang, Jie, Yang, Shiming, Vera, Krystal, Hu, Bo Hua
    PLoS ONE, 2014, Vol.9(12) [Peer Reviewed Journal]

    • Several versions

    Molecular Epidemiology and Functional Assessment of Novel Allelic Variants of SLC26A4 in Non-Syndromic Hearing Loss Patients with Enlarged Vestibular Aqueduct in China ( SLC26A4 Molecular Epidemiology and Function Study)

    Yuan, Yongyi, Guo, Weiwei, Tang, Jie, Zhang, Guozheng, Wang, Guojian, Han, Mingyu, Zhang, Xun, Yang, Shiming, He, David Z. Z, Dai, Pu
    2012, Vol.7(11), p.e49984 [Peer Reviewed Journal]

    • Several versions

    Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs through an Antioxidant Effect (Hydrogen Protects Noise-Induced Hearing Loss)

    Chen, Liwei, Yu, Ning, Lu, Yan, Wu, Longjun, Chen, Daishi, Guo, Weiwei, Zhao, Lidong, Liu, Mingbo, Yang, Shiming, Sun, Xuejun, Zhai, Suoqiang
    2014, Vol.9(6), p.e100774 [Peer Reviewed Journal]

    • Several versions

    Genetic and Phenotypic Heterogeneity in Chinese Patients with Waardenburg Syndrome Type II

    Yang, Shuzhi, Dai, Pu, Liu, Xin, Kang, Dongyang, Zhang, Xin, Yang, Weiyan, Zhou, Chengyong, Yang, Shiming, Yuan, Huijun
    PLoS ONE, 2013, Vol.8(10) [Peer Reviewed Journal]

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    Cell junction proteins within the cochlea: A review of recent research

    Wang, Bo, Hu, Bohua, Yang, Shiming
    Journal of otology, December 2015, Vol.10(4), pp.131-135 [Peer Reviewed Journal]
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    Title: Cell junction proteins within the cochlea: A review of recent research
    Author: Wang, Bo; Hu, Bohua; Yang, Shiming
    Subject: Cell Junction ; Cochlea ; Junction Proteins
    Description: Cell-cell junctions in the cochlea are highly complex and well organized. The role of these junctions is to maintain structural and functional integrity of the cochlea. In this review, we describe classification of cell junction-associated proteins identified within the cochlea and provide a brief overview of the function of these proteins in adherent junctions, gap junctions and tight junctions.
    Is part of: Journal of otology, December 2015, Vol.10(4), pp.131-135
    Identifier: 2524-1753 (E-ISSN); 29937796 Version (PMID); 10.1016/j.joto.2016.01.003 (DOI)

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    Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis

    Du, Chao, Yang, Shiming, Zhao, Xiaoyan, Dong, Hui
    Oncotarget, 25 April 2017, Vol.8(17), pp.29474-29486 [Peer Reviewed Journal]
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    Title: Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis
    Author: Du, Chao; Yang, Shiming; Zhao, Xiaoyan; Dong, Hui
    Subject: Gastric Cancer ; Tumorigenesis ; Vitamin D ; Vitamin D Receptor ; Receptors, Calcitriol -- Metabolism ; Stomach -- Pathology ; Stomach Neoplasms -- Diet Therapy ; Vitamin D Deficiency -- Therapy
    Description: Gastric cancer is currently the second leading cause of cancer-related death worldwide, especially in Japan, Korea and China, and the 5-year survival rate of gastric cancer is less than 30%. Thus, it is important to shed more lights on novel agents to prevent gastric cancer or to improve survival rate of the patients. Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor. Although epidemiological results are not consistent, accumulating evidence from gastric cancer cells, animal models, and clinical trials suggest that vitamin D deficiency may increase the risk and mortality of gastric cancer, but vitamin D supplement might be a safe and economical way to prevent or treat gastric cancer. Here, we reviewed the current studies on vitamin D and its receptor and focused on the pathogenic roles of their alterations in gastric tumorigenesis.
    Is part of: Oncotarget, 25 April 2017, Vol.8(17), pp.29474-29486
    Identifier: 1949-2553 (E-ISSN); 28206978 Version (PMID); 10.18632/oncotarget.15298 (DOI)

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    Extrinsic sound stimulations and development of periphery auditory synapses

    Hou, Kun, Yang, Shiming, Liu, Ke
    Journal of otology, June 2015, Vol.10(2), pp.47-50 [Peer Reviewed Journal]
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    Title: Extrinsic sound stimulations and development of periphery auditory synapses
    Author: Hou, Kun; Yang, Shiming; Liu, Ke
    Subject: Cochlea ; Development ; Periphery ; Ribbon Synapse ; Sound Stimulation
    Description: The development of auditory synapses is a key process for the maturation of hearing function. However, it is still on debate regarding whether the development of auditory synapses is dominated by acquired sound stimulations. In this review, we summarize relevant publications in recent decades to address this issue. Most reported data suggest that extrinsic sound stimulations do affect, but not govern the development of periphery auditory synapses. Overall, periphery auditory synapses develop and mature according to its intrinsic mechanism to build up the synaptic connections between sensory neurons and/or interneurons.
    Is part of: Journal of otology, June 2015, Vol.10(2), pp.47-50
    Identifier: 2524-1753 (E-ISSN); 29937781 Version (PMID); 10.1016/j.joto.2015.09.006 (DOI)

    • Several versions

    Cogels of Hyaluronic Acid and Acellular Matrix for Cultivation of Adipose-Derived Stem Cells: Potential Application for Vocal Fold Tissue Engineering

    Huang, Dongyan, Wang, Rongguang, Yang, Shiming
    BioMed Research International, 2016, Vol.2016, 10 pages [Peer Reviewed Journal]