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    • Several versions

    Combined Adenovirus-Mediated Artificial microRNAs Targeting mfgl2, mFas, and mTNFR1 Protect against Fulminant Hepatic Failure in Mice (Virus-Mediated miRNA Treatment of Hepatic Failure)

    Xi, Dong, Wang, Ming, Ye, Huali, Luo, Xiaoping, Ning, Qin
    2013, Vol.8(11), p.e82330 [Peer Reviewed Journal]

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    Dual interference with novel genes mfgl2 and mTNFR1 ameliorates murine hepatitis virus type 3-induced fulminant hepatitis in BALB/cJ mice

    Gao, Sui, Wang, Ming, Ye, Huali, Guo, Jianwen, Xi, Dong, Wang, Zhimo, Zhu, Chuanglong, Yan, Weiming, Luo, Xiaoping, Ning, Qin
    Human gene therapy, August 2010, Vol.21(8), pp.969-77 [Peer Reviewed Journal]
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    Title: Dual interference with novel genes mfgl2 and mTNFR1 ameliorates murine hepatitis virus type 3-induced fulminant hepatitis in BALB/cJ mice
    Author: Gao, Sui; Wang, Ming; Ye, Huali; Guo, Jianwen; Xi, Dong; Wang, Zhimo; Zhu, Chuanglong; Yan, Weiming; Luo, Xiaoping; Ning, Qin
    Subject: RNA Interference ; Fibrinogen -- Genetics ; Liver Failure, Acute -- Genetics ; Murine Hepatitis Virus -- Genetics ; Receptors, Tumor Necrosis Factor, Type I -- Genetics
    Description: Our studies and those of many others have implicated hepatocyte necrosis and apoptosis mediated by fibrinogen-like protein-2 (fgl2) prothrombinase and tumor necrosis factor receptor (TNFR) in the development of fulminant viral hepatitis, a disease with a mortality rate greater than 80% in cases lacking immediate organ transplantation. This study was designed to explore the efficacy of dual short hairpin RNA (shRNA) interference with fgl2 and TNFR1 in the treatment of murine hepatitis virus strain 3 (MHV-3)-induced fulminant hepatitis in mice. Plasmids p-mfgl2shRNA and p-mTNFR1shRNA, complementary to the sequences for mfgl2 and mTNFR1, were constructed. Plasmids pEGFP-mfgl2 and pEGFP-mTNFR1 expressing mfgl2-EGFP (enhanced green fluorescent protein) and mTNFR1-EGFP fusion proteins were also constructed to screen the inhibitory effect of p-mfgl2shRNA and p-mTNFR1shRNA on mfgl2 and mTNFR1 expression. Cotransfection of individual shRNA plasmids and pcDNA3.0-mfgl2 and pcDNA3.0-mTNFR1 expression...
    Is part of: Human gene therapy, August 2010, Vol.21(8), pp.969-77
    Identifier: 1557-7422 (E-ISSN); 20218879 Version (PMID); 10.1089/hum.2009.177 (DOI)

    • Several versions

    Circular RNA circTUBGCP3 Is Up-Regulated and Promotes Cell Proliferation, Migration and Survivability via Sponge mir-30b in Osteosarcoma

    Xu, Yining, Yao, Teng, Huang, Kangmao, Liu, Gang, Huang, Yizhen, Gao, Jun, Ye, Huali, Shen, Shuying, Ma, Jianjun
    OncoTargets and therapy, 2020, Vol.13, pp.3729-3737 [Peer Reviewed Journal]

    • Several versions

    Inhibition of intervertebral disc disease progression via the circPKNOX1-miR-370-3p-KIAA0355 axis

    Huang, Yizhen, Gao, Jun, Wang, Jianle, Ye, Huali, Yao, Teng, Xu, Yining, Chen, Zizheng, Shen, Shuying, Ma, Jianjun
    Cell death discovery, 26 February 2021, Vol.7(1), pp.39 [Peer Reviewed Journal]

    • Several versions

    Circ0083429 Regulates Osteoarthritis Progression via the Mir-346/ Axis

    Yao, Teng, Yang, Yute, Xie, Ziang, Xu, Yining, Huang, Yizhen, Gao, Jun, Shen, Shuying, Ye, Huali, Iranmanesh, Yasaman, Fan, Shunwu, Ma, Jianjun
    Frontiers in cell and developmental biology, 2020, Vol.8, pp.579945 [Peer Reviewed Journal]

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    circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression

    Chen, Zizheng, Xu, Wenbin, Zhang, Deguang, Chu, Junjie, Shen, Shuying, Ma, Yan, Wang, Qingxin, Liu, Gang, Yao, Teng, Huang, Yizhen, Ye, Huali, Wang, Jiying, Ma, Jianjun, Fan, Shunwu
    Molecular therapy. Nucleic acids, 05 March 2021, Vol.23, pp.1120-1135 [Peer Reviewed Journal]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Title: circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression
    Author: Chen, Zizheng; Xu, Wenbin; Zhang, Deguang; Chu, Junjie; Shen, Shuying; Ma, Yan; Wang, Qingxin; Liu, Gang; Yao, Teng; Huang, Yizhen; Ye, Huali; Wang, Jiying; Ma, Jianjun; Fan, Shunwu
    Subject: Anatomy & Physiology;
    Description: Osteosarcoma is the most common primary malignant bone tumor in adolescents. While chemotherapy combined with surgery can improve the prognosis of some patients, chemo-resistance is still a huge obstacle in osteosarcoma treatment. Accumulating evidence demonstrates that circular RNAs (circRNAs) are involved in cancer progression and metastasis, but their specific role in osteosarcoma remains mostly undescribed. In this study, we performed circRNA deep sequencing and identified 88 distinct circRNAs from a human osteosarcoma cell lines group (143B, HOS, SJSA, and U2OS) and the human osteoblast hFOB 1.19 (control). We found that circCAMSAP1, also named hsa_circ_0004338, is significantly upregulated in human osteosarcoma tissues and cell lines, and it is positively correlated with osteosarcoma development. Silencing of circCAMSAP1 effectively suppresses osteosarcoma cell growth, apoptosis, migration, and invasion. Furthermore, we validated that circCAMSAP1 functions in osteosarcoma tumorigenesis...
    Is part of: Molecular therapy. Nucleic acids, 05 March 2021, Vol.23, pp.1120-1135
    Identifier: 2162-2531 (ISSN); 33664993 Version (PMID); 10.1016/j.omtn.2020.12.013 (DOI)