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    Zum Gedenken an Michael Theunissen

    Angehrn, Emil
    Deutsche Zeitschrift für Philosophie. - 2016/64/1/132-139
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    Title: Zum Gedenken an Michael Theunissen
    Author: Angehrn, Emil
    Subject: Research Article
    Linked entry: Deutsche Zeitschrift für Philosophie. - 2016/64/1/132-139
    Host document: Deutsche Zeitschrift für Philosophie
    Identifier: 10.1515/dzph-2016-0009 (DOI)

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    Schwerpunkt: Vertrauen und Vertrauenswürdigkeit

    Budnik, Christian
    Deutsche Zeitschrift für Philosophie. - 2016/64/1/68-72
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    Title: Schwerpunkt: Vertrauen und Vertrauenswürdigkeit
    Author: Budnik, Christian
    Subject: Research Article
    Linked entry: Deutsche Zeitschrift für Philosophie. - 2016/64/1/68-72
    Host document: Deutsche Zeitschrift für Philosophie
    Identifier: 10.1515/dzph-2016-0004 (DOI)

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    Gründe für Vertrauen, Vertrauenswürdigkeit und Kompetenz

    Budnik, Christian
    Deutsche Zeitschrift für Philosophie. - 2016/64/1/103-118
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    Title: Gründe für Vertrauen, Vertrauenswürdigkeit und Kompetenz
    Author: Budnik, Christian
    Subject: Research Article - trust - trustworthiness - voluntarism - nonvoluntarism - competence
    Description: One reason that trust is interesting for philosophers is that there are reasons for trust. We want to know when it is appropriate to trust other people, because trusting foolishly can be dangerous. The paper argues that there are two competing ways of understanding reasons of trust - a non-voluntarist and a voluntarist way. On the non-voluntarist picture, reasons for trust are associated with the trustworthiness of another person. On the voluntarist picture, you can appropriately trust another person without judging her to be trustworthy. In the paper a case is made against the voluntarist interpretation. At the same time it is argued that non-voluntarist theories of trust are faced with a particular problem. This problem has to do with the assumption that in order to appropriately trust another person you have to judge her competent in the relevant area of interaction. It is argued that this competence assumption should not be understood as a necessary condition for trustworthiness but rather as a necessary condition for mere reliability. Doing so helps to solve problems associated with trust in medicine ethics and political philosophy, and it opens up new perspectives for theories of trust.
    Linked entry: Deutsche Zeitschrift für Philosophie. - 2016/64/1/103-118
    Host document: Deutsche Zeitschrift für Philosophie
    Identifier: 10.1515/dzph-2016-0007 (DOI)

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    Higher Vitamin D Dietary Intake Is Associated With Lower Risk of Alzheimer's Disease: A 7-Year Follow-up

    Annweiler, Cédric
    Rolland, Yves, Schott, Anne M, Blain, Hubert, Vellas, Bruno, Herrmann, François R, Beauchet, Olivier
    Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. - 2012/67/11/1205-1211
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    Title: Higher Vitamin D Dietary Intake Is Associated With Lower Risk of Alzheimer's Disease: A 7-Year Follow-up
    Author: Annweiler, Cédric
    Contributor: Rolland, Yves; Schott, Anne M; Blain, Hubert; Vellas, Bruno; Herrmann, François R; Beauchet, Olivier
    Subject: Research Article - Vitamin D - Alzheimers - Diet - Dementia - Older adults
    Description: Background. Hypovitaminosis D is associated with cognitive decline among older adults. The relationship between vitamin D intakes and cognitive decline is not well understood. Our objective was to determine whether the dietary intake of vitamin D was an independent predictor of the onset of dementia within 7 years among women aged 75 years and older. Methods. Four hundred and ninety-eight community-dwelling women (mean, 79.8 ± 3.8 years) free of vitamin D supplements from the EPIDemiology of OSteoporosis Toulouse cohort study were divided into three groups according to the onset of dementia within 7 years (ie, no dementia, Alzheimer's disease [AD], or other dementias). Baseline vitamin D dietary intakes were estimated from self-administered food frequency questionnaire. Age, body mass index, initial cognitive performance, education level, physical activity, sun exposure, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and baseline season were considered as potential confounders. Results. Women who developed AD (n = 70) had lower baseline vitamin D intakes (mean, 50.3 ± 19.3 μg/wk) than nondemented (n = 361; mean intake = 59.0 ± 29.9 μg/wk, p = .027) or those who developed other dementias (n = 67; mean intake = 63.6 ± 38.1 μg/wk, p = .010). There was no difference between other dementias and no dementia (p = .247). Baseline vitamin D dietary intakes were associated with the onset of AD (adjusted odds ratio = 0.99 [95% confidence interval = 0.98-0.99], p = .041) but not with other dementias (p = .071). Being in the highest quintile of vitamin D dietary intakes was associated with a lower risk of AD compared with the lower 4 quintiles combined (adjusted odds ratio = 0.23 [95% confidence interval = 0.08-0.67], p = .007). Conclusions. Higher vitamin D dietary intake was associated with a lower risk of developing AD among older women
    Linked entry: Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. - 2012/67/11/1205-1211
    Host document: Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences
    Identifier: 10.1093/gerona/gls107 (DOI)

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    Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice

    Peng, Xu
    Ueda, Hiroki, Zhou, Hongming, Stokol, Tracy, Shen, Tang-Long, Alcaraz, Ana, Nagy, Tamas, Vassalli, Jean-Dominique, Guan, Jun-Lin
    Cardiovascular Research. - 2004/64/3/421-430
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    Title: Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice
    Author: Peng, Xu
    Contributor: Ueda, Hiroki; Zhou, Hongming; Stokol, Tracy; Shen, Tang-Long; Alcaraz, Ana; Nagy, Tamas; Vassalli, Jean-Dominique; Guan, Jun-Lin
    Subject: Research Article - Focal adhesion kinase - Angiogenesis - Transgenic mouse - Endothelial cells
    Description: Objective: Focal adhesion kinase is implicated in the regulation of cell adhesion, migration, survival, and cell-cycle progression. However, the functions of focal adhesion kinase in endothelial cell (EC) in vivo remain unclear. This study aims to examine the role of FAK in EC function and angiogenesis in vivo by transgenic mice approach. Method: We generated transgenic mice which overexpressed chicken FAK in vascular endothelial cell under the control of the Tie-2 promoter and enhancer. FAK transgene was detected by RT-PCR, immunoprecipitation, and Western blot. The effect of FAK overexpression on angiogenesis was determined using skin wound healing and ischemia skeleton muscle models. Results: Expression of FAK transgene was detected in all vessel-rich tissues. Expression of FAK protein was verified by antibody specific for the exogenous chicken FAK in lung homogenates and isolated EC. In the wound-induced angiogenesis model, the number of vessels in the granulation tissue of healing wound was significantly increased in the transgenic mouse compared to that of wild-type control mice. Similarly, in the ischemia skeleton muscle model, the density of capillaries was significantly increased in the transgenic mouse. Conclusion: These results indicate that FAK may play an important role in the promotion of angiogenesis in vivo
    Linked entry: Cardiovascular Research. - 2004/64/3/421-430
    Host document: Cardiovascular Research
    Identifier: 10.1016/j.cardiores.2004.07.012 (DOI)

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    Tugend, Recht und Moral: Tendenzen der Verantwortungszuschreibung

    Eckert, Julia
    Deutsche Zeitschrift für Philosophie. - 2016/64/2/246-257
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    Title: Tugend, Recht und Moral: Tendenzen der Verantwortungszuschreibung
    Author: Eckert, Julia
    Subject: Research Article - virtue - law - charity - responsibility - social anthropology
    Description: The attribution of responsibility in world society is increasingly a field of contestation. On the one hand, the perceptions of far-reaching causal and moral links between spatially and temporally distant events are ever more explicitly pronounced; on the other hand, the very complexity of these links often engenders a fragmentation of responsibility in law as well as in moral commitment. Identifying three competing conceptualisations of responsibility, namely a turn to virtue ethics, processes of juridification, and processes of moralisation, this article explores their different temporal and social dimensions, and the effects they each have on the relation between those held responsible and those affected by the situation that is to be accounted for.
    Linked entry: Deutsche Zeitschrift für Philosophie. - 2016/64/2/246-257
    Host document: Deutsche Zeitschrift für Philosophie
    Identifier: 10.1515/dzph-2016-0018 (DOI)

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    Pragmatistische Erneuerung der globalen Gerechtigkeitsdebatte

    Festl, Michael G
    Deutsche Zeitschrift für Philosophie. - 2016/64/5/780-792
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    Title: Pragmatistische Erneuerung der globalen Gerechtigkeitsdebatte
    Author: Festl, Michael G
    Subject: Research Article - pragmatism - global justice - historic experimentalism - cosmopolitanism
    Description: The article explicates how the pragmatic account of justice which is called ‘justice as historic experimentalism' can be applied to the debate on global justice. It investigates thereby the role that normative justifications of the nation-state ought to play in global theories of justice. It argues that one distinctive element of pragmatic approaches, as opposed to the dominant approaches in the field of global justice, is that arguments on the role of the nation-state do not occupy a central position. Rather, it is concrete problems of justice and their experimental and historic examination that guide the pragmatist inquiry. The role of the nation-state has to fall in line. The problem of global economic in equalities is invoked to illustrate the merits of the pragmatist approach to justice here presented.
    Linked entry: Deutsche Zeitschrift für Philosophie. - 2016/64/5/780-792
    Host document: Deutsche Zeitschrift für Philosophie
    Identifier: 10.1515/dzph-2016-0058 (DOI)

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    Peroxisome proliferator-activated receptor β/δ activation inhibits hypertrophy in neonatal rat cardiomyocytes

    Planavila, Anna
    Rodríguez-Calvo, Ricardo, Jové, Mireia, Michalik, Liliane, Wahli, Walter, Laguna, Juan C, Vázquez-Carrera, Manuel
    Cardiovascular Research. - 2005/65/4/832-841
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    Title: Peroxisome proliferator-activated receptor β/δ activation inhibits hypertrophy in neonatal rat cardiomyocytes
    Author: Planavila, Anna
    Contributor: Rodríguez-Calvo, Ricardo; Jové, Mireia; Michalik, Liliane; Wahli, Walter; Laguna, Juan C; Vázquez-Carrera, Manuel
    Subject: Research Article - Cardiac hypertrophy - NF-κB - L-165041 - p65
    Description: Objective: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is the predominant PPAR subtype in cardiac cells and plays a prominent role in the regulation of cardiac lipid metabolism. However, the role of PPARβ/δ activators in cardiac hypertrophy is not yet known. Methods and Results: In cultured neonatal rat cardiomyocytes, the selective PPARβ/δ activator L-165041 (10 μmol/L) inhibited phenylephrine (PE)-induced protein synthesis ([3H]leucine uptake), induction of the fetal-type gene atrial natriuretic factor (ANF) and cardiac myocyte size. Induction of cardiac hypertrophy by PE stimulation also led to a reduction in the transcript levels of both muscle-type carnitine palmitoyltransferase (50%, P
    Linked entry: Cardiovascular Research. - 2005/65/4/832-841
    Host document: Cardiovascular Research
    Identifier: 10.1016/j.cardiores.2004.11.011 (DOI)

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    T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells

    Ivanov, Danila
    Philippova, Maria, Allenspach, Roy, Erne, Paul, Resink, Thérèse
    Cardiovascular Research. - 2004/64/1/132-143
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    Title: T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells
    Author: Ivanov, Danila
    Contributor: Philippova, Maria; Allenspach, Roy; Erne, Paul; Resink, Thérèse
    Subject: Research Article - T-cadherin - Vascular cells - Cell cycle - Proliferation - Adenoviral expression
    Description: Objective: In vascular tissue, T-cadherin (T-cad) levels correlate with the progression of atherosclerosis, restenosis and tumour neovascularization. This study investigates whether T-cad influences proliferation of vascular cells. Methods and Results: Cultures of human umbilical vein endothelial cells (HUVEC) and rat and human aortic smooth muscle cells (rSMC, hSMC) were used. T-cad was overexpressed in HUVEC and hSMC using an adenoviral expression system. In cultures released from G1/G0 synchrony parallel immunoblot analysis of T-cad and cell cycle phase specific markers (p27Kip1, cyclin D1, E2F1, PCNA, cyclin B) showed increased T-cad protein levels subsequent to entry into early S-phase with sustained elevation through S-and M-phases. T-cad was increased in G2/M-phase (colchicine) synchronized cultures. In FACS-sorted cell populations, expression of T-cad in S-and G2/M-phase was higher than G1/G0-phase. Compared with empty-and LacZ-vector infected controls, HUVEC and hSMC overexpressing T-cad exhibited increased proliferation as assessed in enumeration and DNA synthesis assays. Additionally, following release from G1/G0 synchrony, HUVEC and hSMC overexpressing T-cad enter S-phase more rapidly. Flow cytometry after BrdU/propidium labelling confirmed increased cell cycle progression in T-cad overexpressing cells. Conclusion: In vascular cells, T-cad is dynamically regulated during the cell cycle and its expression functions in the promotion of proliferation. T-cad may facilitate progression of proliferative vascular disorders such as atherosclerosis, restenosis and tumour angiogenesis
    Linked entry: Cardiovascular Research. - 2004/64/1/132-143
    Host document: Cardiovascular Research
    Identifier: 10.1016/j.cardiores.2004.06.010 (DOI)

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    Regulation of glucose transporter expression in cardiac myocytes: p38 MAPK is a strong inducer of GLUT4

    Montessuit, Christophe
    Rosenblatt-Velin, Nathalie, Papageorgiou, Irène, Campos, Lis, Pellieux, Corinne, Palma, Tatiana, Lerch, René
    Cardiovascular Research. - 2004/64/1/94-104
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    Title: Regulation of glucose transporter expression in cardiac myocytes: p38 MAPK is a strong inducer of GLUT4
    Author: Montessuit, Christophe
    Contributor: Rosenblatt-Velin, Nathalie; Papageorgiou, Irène; Campos, Lis; Pellieux, Corinne; Palma, Tatiana; Lerch, René
    Subject: Research Article - Gene expression - Growth factors - Cell culture/isolation - Cell differentiation - MAP kinase
    Description: Objective: In vivo differentiation of cardiac myocytes is associated with downregulation of the glucose transporter isoform GLUT1 and upregulation of the isoform GLUT4. Adult rat cardiomyocytes in primary culture undergo spontaneous dedifferentiation, followed by spreading and partial redifferentiation, which can be influenced by growth factors. We used this model to study the signaling mechanisms modifying the expression of GLUT4 in cardiac myocytes. Results: Adult rat cardiomyocytes in primary culture exhibited spontaneous upregulation of GLUT1 and downregulation of GLUT4, suggesting resumption of a fetal program of GLUT gene expression. Treatment with IGF-1 and, to a minor extent, FGF-2 resulted in restored expression of GLUT4 protein and mRNA. Activation of p38 MAPK mediated the increased expression of GLUT4 in response to IGF-1. Transient transfection experiments in neonatal cardiac myocytes confirmed that p38 MAPK could activate the glut4 promoter. Electrophoretic mobility shift assay in adult rat cardiomyocytes and transient transfection experiments in neonatal cardiac myocytes indicated that MEF2 was the main transcription factor transducing the effect of p38 MAPK activation on the glut4 promoter. Conclusion: Spontaneous dedifferentiation of adult rat cardiomyocytes in vitro is associated with downregulation of GLUT4, which can be reversed by treatment with IGF-1. The effect of IGF-1 is mediated by the p38 MAPK/MEF2 axis, which is a strong inducer of GLUT4 expression
    Linked entry: Cardiovascular Research. - 2004/64/1/94-104
    Host document: Cardiovascular Research
    Identifier: 10.1016/j.cardiores.2004.06.005 (DOI)