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    • Plusieurs versions

    What's wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice

    Crawley, Jacqueline N
    • Revue
    Sélectionner

    Current protocols in neuroscience

    Crawley, Jacqueline N
    New York : J. Wiley
    1997-
    Disponible
    Plus…
    Chargement
    Erreur de chargement
    Titre: Current protocols in neuroscience / ed. board by Jacqueline N. Crawley ... [et al.]
    Auteur: Crawley, Jacqueline N
    Editeur: New York : J. Wiley
    Date: 1997-
    Périodicité: Mise à jour en continu
    Note: Ressource en ligne consultée le 5 février 2013 - Existe aussi sous forme papier
    Identifiant: 9780471142300 (ISBN)
    No RERO: R008421228
    Permalien:
    http://data.rero.ch/01-R008421228/html?view=FR_V1

    • Plusieurs versions

    In tribute to Bob Blanchard: Divergent behavioral phenotypes of 16p11.2 deletion mice reared in same-genotype versus mixed-genotype cages

    Yang, Mu, Lewis, Freeman, Foley, Gillian, Crawley, Jacqueline N
    Physiology & Behavior, 01 July 2015, Vol.146, pp.16-27 [Revue évaluée par les pairs]

    • Article
    Sélectionner

    Low home cage social behaviors in BTBR T+tf/J mice during juvenile development

    Babineau , Brooke A., Yang , Mu, Berman , Robert F., Crawley , Jacqueline N.
    Physiology & behavior, 2013, Vol.114, pp.49-54 [Revue évaluée par les pairs]
    AGRIS (Food and Agriculture Organization of the United Nations)
    Disponible
    Plus…
    Titre: Low home cage social behaviors in BTBR T+tf/J mice during juvenile development
    Auteur: Babineau , Brooke A.; Yang , Mu; Berman , Robert F.; Crawley , Jacqueline N.
    Sujet: Mice ; Adulthood ; Autism ; Cages ; Adults ; Weaning ; Animal Models ; Strain Differences ; Social Behavior
    Description: BTBR T+tf/J (BTBR) is a genetically homogenous inbred strain of mice that displays abnormal social behaviors, deficits in vocalizations, and high levels of repetitive behaviors, relevant to the three diagnostic symptoms of autism spectrum disorder, leading to the use of this strain as a mouse model of autism. Comprehensive observations of BTBR social behaviors within the home cage during early stages of development have not been conducted. Here we evaluate the home cage behaviors of BTBR in two laboratory environments (NIMH, Bethesda, Maryland vs. UC Davis, Davis, California), starting from the day of weaning and continuing into adulthood. Extensive ethogram parameters were scored for BTBR in home cages that contained four BTBR conspecifics, versus home cages that contained four C57BL/6J (B6) conspecifics. BTBR were considerably less interactive than B6 in the home cage at both sites, as measured during the early dark stage of their circadian cycle. A novel home cage behavioral measure, frequency of long interactions, was found to be more frequent and of longer duration in B6 versus BTBR home cages across experimental sites. Significant strain differences in the occurrence of investigative and affiliative behaviors were also seen, however these findings were not fully consistent across the two testing sites. At the end of the 30-day home cage observation period, each seven-week old subject mouse was tested in the three-chambered social approach task. BTBR displayed lack of sociability and B6 displayed significant sociability, consistent with previous reports. Our findings reveal that BTBR engaged in lower levels of some components of spontaneous conspecific social interactions in the home cage environment throughout juvenile development, consistent with their deficits in juvenile and adult sociability as measured in specialized social tasks. ; p. 49-54.
    Fait partie de: Physiology & behavior, 2013, Vol.114, pp.49-54
    Identifiant: 0031-9384 (ISSN)

    • Plusieurs versions

    Low home cage social behaviors in BTBR T+tf/J mice during juvenile development

    Babineau, Brooke A, Yang, Mu, Berman, Robert F, Crawley, Jacqueline N
    Physiology & Behavior, 10 April 2013, Vol.114-115, pp.49-54 [Revue évaluée par les pairs]

    • Plusieurs versions

    Female urine-induced male mice ultrasonic vocalizations, but not scent-marking, is modulated by social experience

    Roullet, Florence I, Wöhr, Markus, Crawley, Jacqueline N
    Behavioural Brain Research, 2011, Vol.216(1), pp.19-28 [Revue évaluée par les pairs]

    • Plusieurs versions

    Testing Hypotheses about Autism

    Crawley, Jacqueline N., Jacqueline N. Crawley
    Science, 5 October 2007, Vol.318(5847), pp.56-57 [Revue évaluée par les pairs]

    • Plusieurs versions

    Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

    Tsai, Peter Tzu-Shin, Hull, Court, Chu, Yunxiang, Greene-Colozzi, Emily, Sadowski, Abbey R., Leech, Jarrett M., Steinberg, Jason, Crawley, Jacqueline N., Regehr, Wade G., Sahin, Mustafa
    Tsai, Peter T., Court Hull, YunXiang Chu, Emily Greene-Colozzi, Abbey R. Sadowski, Jarrett M. Leech, Jason Steinberg, Jacqueline N. Crawley, Wade G. Regehr, and Mustafa Sahin. 2013. Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature 488(7413): 647-651. [Revue évaluée par les pairs]

    • Plusieurs versions

    Neuroanatomical analysis of the BTBR mouse model of autism using magnetic resonance imaging and diffusion tensor imaging

    Ellegood, Jacob, Babineau, Brooke A, Henkelman, R. Mark, Lerch, Jason P, Crawley, Jacqueline N
    NeuroImage, 15 April 2013, Vol.70, pp.288-300 [Revue évaluée par les pairs]

    • Plusieurs versions

    Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

    Kazdoba, Tatiana, Hagerman, Randi, Zolkowska, Dorota, Rogawski, Michael, Crawley, Jacqueline
    Psychopharmacology, 2016, Vol.233(2), pp.309-323 [Revue évaluée par les pairs]