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    • Plusieurs versions

    Astatine-211 labeling: a study towards automatic production of astatinated antibodies

    Aneheim, Emma, Jensen, Holger, Albertsson, Per, Lindegren, Sture
    Journal of Radioanalytical and Nuclear Chemistry, 2015, Vol.303(1), pp.979-983 [Revue évaluée par les pairs]

    • Plusieurs versions

    Extraction of 211 At from nitric acid solutions into various organic solvents for use as an α -source for radiation chemistry studies

    Ekberg, Christian, Jensen, Holger, Mezyk, Stephen, Mincher, Bruce, Skarnemark, Gunnar
    Journal of Radioanalytical and Nuclear Chemistry, 2017, Vol.314(1), pp.235-239 [Revue évaluée par les pairs]

    • Plusieurs versions

    Synthesis and Evaluation of Astatinated N‑[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates

    Aneheim, Emma, Gustafsson, Anna, Albertsson, Per, Bäck, Tom, Jensen, Holger, Palm, Stig, Svedhem, Sofia, Lindegren, Sture
    Bioconjugate chemistry, 16 March 2016, Vol.27(3), pp.688-697 [Revue évaluée par les pairs]

    • Plusieurs versions

    Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    Lyckesvärd, Madeleine Nordén, Delle, Ulla, Kahu, Helena, Lindegren, Sture, Jensen, Holger, Bäck, Tom, Swanpalmer, John, Elmroth, Kecke
    Mutation research, July 2014, Vol.765, pp.48-56 [Revue évaluée par les pairs]

    • Plusieurs versions

    Tsalen- and Tsalpn-Based Nickel Complexes with Two Aldehyde Functionalities as Potential Synthons for Thiophenolate-Containing Di- and Polynucleating Acyclic and Macrocyclic Ligands

    Christensen, Aase, Jensen, Holger S, Mckee, Vickie, Mckenzie, Christine J, Munch, Maria
    Inorganic chemistry, 17 December 1997, Vol.36(26), pp.6080-6085 [Revue évaluée par les pairs]

    • Plusieurs versions

    Therapeutic Efficacy of Astatine-211–Labeled Trastuzumab on Radioresistant SKOV-3 Tumors in Nude Mice

    Palm, Stig, Bäck, Tom, Claesson, Ingela, Danielsson, Anna, Elgqvist, Jörgen, Frost, Sofia, Hultborn, Ragnar, Jensen, Holger, Lindegren, Sture, Jacobsson, Lars
    International journal of radiation oncology, biology, physics, 2007, Vol.69(2), pp.572-579 [Revue évaluée par les pairs]

    • Article
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    Direct procedure for the production of 211At-labeled antibodies with an epsilon-lysyl-3-(trimethylstannyl)benzamide immunoconjugate

    Lindegren, Sture, Frost, Sofia, Bäck, Tom, Haglund, Elin, Elgqvist, Jörgen, Jensen, Holger
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, September 2008, Vol.49(9), pp.1537-45 [Revue évaluée par les pairs]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Titre: Direct procedure for the production of 211At-labeled antibodies with an epsilon-lysyl-3-(trimethylstannyl)benzamide immunoconjugate
    Auteur: Lindegren, Sture; Frost, Sofia; Bäck, Tom; Haglund, Elin; Elgqvist, Jörgen; Jensen, Holger
    Sujet: Antibodies, Monoclonal -- Chemistry ; Astatine -- Chemistry ; Benzamides -- Chemistry
    Description: (211)At-labeled tumor-specific antibodies have long been considered for the treatment of disseminated cancer. However, the limited availability of the nuclide and the poor efficacy of labeling procedures at clinical activity levels present major obstacles to their use. This study evaluated a procedure for the direct astatination of antibodies for the production of clinical activity levels. The monoclonal antibody trastuzumab was conjugated with the reagent N-succinimidyl-3-(trimethylstannyl)benzoate, and the immunoconjugate was labeled with astatine. Before astatination of the conjugated antibody, the nuclide was activated with N-iodosuccinimide. The labeling reaction was evaluated in terms of reaction time, volume of reaction solvent, immunoconjugate concentration, and applied activity. The quality of the astatinated antibodies was determined by in vitro analysis and biodistribution studies in nude mice. The reaction proceeded almost instantaneously, and the results indicated a low dependence on immunoconjugate concentration and applied activity. Radiochemical labeling yields were in the range of 68%-81%, and a specific radioactivity of up to 1 GBq/mg could be achieved. Stability and radiochemical purity were equal to or better than those attained with a conventional 2-step procedure. Dissociation constants for directly astatinated, conventionally astatinated, and radioiodinated trastuzumab were 1.0+/-0.06 (mean+/-SD), 0.44+/-0.06, and 0.29+/-0.02 nM, respectively. The tissue distribution in non-tumor-bearing nude mice revealed only minor differences in organ uptake relative to that obtained with the conventional method. The direct astatination procedure enables the high-yield production of astatinated antibodies with radioactivity in the amounts required for clinical applications.
    Fait partie de: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, September 2008, Vol.49(9), pp.1537-45
    Identifiant: 0161-5505 (ISSN); 18703591 Version (PMID); 10.2967/jnumed.107.049833 (DOI)

    • Brevet
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    Wide angle rear projection lenticular lens system

    Jensen, Holger, Scott, Steve M
    Espacenet (European Patent Office)
    Disponible
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    Titre: Wide angle rear projection lenticular lens system
    Auteur: Jensen; Holger; Scott; Steve M
    Date: 27 June 1995
    Sujet: Physics ; Photography ; Cinematography ; Electrography ; Holography ; Apparatus OR Arrangements FOR Taking Photographs OR Forprojecting OR Viewing Them ; Apparatus OR Arrangements Employing Analogous Techniques Usingwaves Other Than Optical Waves ; Accessories Therefor ; Medicine ; Sciences ; Chemistry ; Physics
    Description: A wide angle lenticular lens system for a single piece rear projection screen including a plurality of substantially identical parallel and vertical lenticular lenses. Each of the plurality of lenticular lenses is substantially a single element lens and the shape of each of the plurality of lenticular lenses is substantially defined by a hyperbolic function.

    • Brevet
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    Comparing matrix

    Jensen Holger R
    Espacenet (European Patent Office)
    Disponible
    Plus…
    Titre: Comparing matrix
    Auteur: Jensen Holger R
    Date: 18 August 1964
    Sujet: Medicine ; Sciences ; Chemistry

    • Brevet
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    Titre: Förfaringssätt och anordning för framställning av sådana av plastiska ämnen gjorda föremål i vilka ingjutits öglor eller dylikt
    Auteur: Jensen Holger Christian
    Date: 10 November 1952
    Sujet: Medicine ; Sciences ; Chemistry