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    • Plusieurs versions

    Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with {sup 211}At-MX35 F(ab'){sub 2}

    Elgqvist, Joergen, Andersson, Hakan, Bernhardt, Peter, Baeck, Tom, Claesson, Ingela, Hultborn, Ragnar, Jensen, Holger, Johansson, Bengt R, Lindegren, Sture, Olsson, Marita, Palm, Stig, Warnhammar, Elisabet, Jacobsson, Lars
    International Journal of Radiation Oncology, Biology and Physics, 15 November 2006, Vol.66(4) [Revue évaluée par les pairs]

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    Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35 F(ab′) 2

    Elgqvist, Jörgen, Andersson, Håkan, Bernhardt, Peter, Bäck, Tom, Claesson, Ingela, Hultborn, Ragnar, Jensen, Holger, Johansson, Bengt R, Lindegren, Sture, Olsson, Marita, Palm, Stig, Warnhammar, Elisabet, Jacobsson, Lars
    International journal of radiation oncology, biology, physics, 2006, Vol.66(4), pp.1228-1237 [Revue évaluée par les pairs]
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    Titre: Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35 F(ab′) 2
    Auteur: Elgqvist, Jörgen; Andersson, Håkan; Bernhardt, Peter; Bäck, Tom; Claesson, Ingela; Hultborn, Ragnar; Jensen, Holger; Johansson, Bengt R; Lindegren, Sture; Olsson, Marita; Palm, Stig; Warnhammar, Elisabet; Jacobsson, Lars
    Sujet: Ovarian Cancer ; Radioimmunotherapy ; Dosimetry ; Mx35 ; Astatine ; Ovarian Cancer ; Radioimmunotherapy ; Dosimetry ; Mx35 ; Astatine ; Medicine
    Description: Purpose: To elucidate the therapeutic efficacy of α-radioimmunotherapy of ovarian cancer in mice. This study: (i) estimated the minimum required activity (MRA), giving a reasonable high therapeutic efficacy; and (ii) calculated the specific energy to tumor cell nuclei and the metastatic cure probability (MCP) using various assumptions regarding monoclonal-antibody (mAb) distribution in measured tumors. The study was performed using the α-particle emitter Astatine-211 ( 211At) labeled to the mAb MX35 F(ab′) 2. Methods and Materials: Animals were inoculated intraperitoneally with ∼1 × 10 7 cells of the cell line NIH:OVCAR-3. Four weeks later animals were treated with 25, 50, 100, or 200 kBq 211At-MX35 F(ab′) 2 ( n = 74). Another group of animals was treated with a nonspecific mAb: 100 kBq 211At-Rituximab F(ab′) 2 ( n = 18). Eight weeks after treatment the animals were sacrificed and presence of macro- and microscopic tumors...
    Fait partie de: International journal of radiation oncology, biology, physics, 2006, Vol.66(4), pp.1228-1237
    Identifiant: 0360-3016 (ISSN); 1879-355X (E-ISSN); 10.1016/j.ijrobp.2006.07.003 (DOI)

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    Dry-distillation of astatine-211 from irradiated bismuth targets: a time-saving procedure with high recovery yields

    Lindegren, Sture, Bäck, Tom, Jensen, Holger J
    Applied radiation and isotopes, 2001, Vol.55(2), pp.157-160 [Revue évaluée par les pairs]

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    Astatine-211: The Chemistry Infrastructure

    Lindegren, Sture, Bäck, Tom, Palm, Stig, Jensen, Holger, Albertsson, Per, Aneheim, Emma
    Journal of medical imaging and radiation sciences, December 2019, Vol.50(4), pp.S94-S94 [Revue évaluée par les pairs]
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    Titre: Astatine-211: The Chemistry Infrastructure
    Auteur: Lindegren, Sture; Bäck, Tom; Palm, Stig; Jensen, Holger; Albertsson, Per; Aneheim, Emma
    Sujet: Medicine
    Fait partie de: Journal of medical imaging and radiation sciences, December 2019, Vol.50(4), pp.S94-S94
    Identifiant: 1939-8654 (ISSN); 1876-7982 (E-ISSN); 10.1016/j.jmir.2019.11.081 (DOI)

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    Quantified Cell Binding of Astatinated Immunoconjugates on Ovarian Cancer Cell Spheroids by Alpha Camera Imaging

    Back, Tom, Verhoeven, Marjolein, Aneheim, Emma, Albertsson, Per, Palm, Stig, Lindegren, Sture, Jensen, Holger
    Journal of medical imaging and radiation sciences, March 2019, Vol.50(1), pp.S36-S37 [Revue évaluée par les pairs]
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    Front Cover: Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking (ChemPlusChem 7/2019)

    Denk, Christoph, Wilkovitsch, Martin, Aneheim, Emma, Herth, Matthias M., Jensen, Holger, Lindegren, Sture, Mikula, Hannes
    ChemPlusChem, 07/2019, Vol.84(7), pp.772-772 [Revue évaluée par les pairs]
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    Titre: Front Cover: Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking (ChemPlusChem 7/2019)
    Auteur: Denk, Christoph; Wilkovitsch, Martin; Aneheim, Emma; Herth, Matthias M.; Jensen, Holger; Lindegren, Sture; Mikula, Hannes
    Fait partie de: ChemPlusChem, 07/2019, Vol.84(7), pp.772-772
    Identifiant: 2192-6506 (ISSN); 2192-6506 (E-ISSN); http (DOI)

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    Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone microtumors

    Bäck, Tom A, Jennbacken, Karin, Hagberg Thulin, Malin, Lindegren, Sture, Jensen, Holger, Olafsen, Tove, Yazaki, Paul J, Palm, Stig, Albertsson, Per, Damber, Jan-Erik, Wu, Anna M, Welén, Karin
    EJNMMI research, 11 February 2020, Vol.10(1), pp.10 [Revue évaluée par les pairs]

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    Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking

    Denk, Christoph, Wilkovitsch, Martin, Aneheim, Emma, Herth, Matthias M., Jensen, Holger, Lindegren, Sture, Mikula, Hannes
    ChemPlusChem, July 2019, Vol.84(7), pp.774-774 [Revue évaluée par les pairs]

    • Plusieurs versions

    Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking

    Denk, Christoph, Wilkovitsch, Martin, Aneheim, Emma, Herth, Matthias M., Jensen, Holger, Lindegren, Sture, Mikula, Hannes
    ChemPlusChem, July 2019, Vol.84(7), pp.775-778 [Revue évaluée par les pairs]

    • Plusieurs versions

    Astatine-211: The Chemistry Infrastructure

    Lindegren, Sture, Bäck, Tom, Palm, Stig, Jensen, Holger, Albertsson, Per, Aneheim, Emma
    Journal of medical imaging and radiation sciences, March 2019, Vol.50(1), pp.S24-S24 [Revue évaluée par les pairs]
    ScienceDirect Journals (Elsevier)