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  • Article
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    123 I-MIBG pulmonary removal: a biochemical marker of minimal lung endothelial cell lesions

    Slosman, Daniel, Polla, Barbara, Donath, Alfred
    European Journal of Nuclear Medicine, 1990, Vol.16(8), pp.633-637 [Revue évaluée par les pairs]
    Springer Science & Business Media B.V.
    Disponible
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    Titre: 123 I-MIBG pulmonary removal: a biochemical marker of minimal lung endothelial cell lesions
    Auteur: Slosman, Daniel; Polla, Barbara; Donath, Alfred
    Sujet: Metaiodobenzylguanizide - Bleomycin lung toxicity - Lung metabolism
    Description: Circulating biogenic amines, such as serotonin or norepinephrine, are cleared by the lung and can be considered as indicators of pulmonary endothelial integrity. An iodinated norepinephrine analogue, metaiodo-benzylguanidine (MIBG), is extracted in the lung by an active, saturable transport system. In order to investigate the use of MIBG lung extraction to detect minimal,lung endothelial cell lesions, an experimental model of initial pulmonary vascular lesions was developed in rats using repeated daily intraperitoneal injection of bleomycin (BLM: 2 U/100 g body weight) over a 5-day period. At this time, a significant decrease of serum angiotensin-converting enzyme activity, an index of endothelial cell metabolism, was observed (214±11 U/ml in controls as compared with 182±11 U/ml in BLM-treated rats, P < 0.05); electron microscopy showed the presence of typical but minimal endothelial cell lesions (blebbing). MIBG extraction (%E MIBG ) was measured using the isolated perfused lung model after a 10-min steady-state period and 2 min of perfusion with 123 I-MIBG (0.1 μCi/ml) and 125 I-labelled human serum albumin (HSA) (0.2 μCi/ml). Intraperitoneal administration of BLM to rats for 5 days resulted in a significant decrease in pulmonary extraction of MIBG. %E MIBG declined from a control value of 24.7%±1.1% in controls to 19.3%±1.6% in BLM-treated rats ( n =27, P
    Fait partie de: European Journal of Nuclear Medicine, 1990, Vol.16(8), pp.633-637
    Identifiant: 0340-6997 (ISSN); 1619-7089 (E-ISSN); 10.1007/BF00998161 (DOI)

  • Article
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    Estimation et gestion du risque de cancer engendré par les produits de filiation du radon

    Romerio-Giudici, Franco, Donath, Alfred
    Radioprotection, 1997, 32, 3, 331-355
    1997
    Disponible
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    Titre: Estimation et gestion du risque de cancer engendré par les produits de filiation du radon
    Auteur: Romerio-Giudici, Franco; Donath, Alfred
    Date: 1997
    Sujet: Risque Radiations ionisantes Cancer broncho-pulmonaire
    Fait partie de: Radioprotection, 1997, 32, 3, 331-355

  • Article
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    131 I-metaiodobenzylguanidine and 125 I-iodoamphetamine

    Slosman, Daniel, Donath, Alfred, Alderson, Philip
    European Journal of Nuclear Medicine, 1989, Vol.15(4), pp.207-210 [Revue évaluée par les pairs]
    Springer Science & Business Media B.V.
    Disponible
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    Titre: 131 I-metaiodobenzylguanidine and 125 I-iodoamphetamine
    Auteur: Slosman, Daniel; Donath, Alfred; Alderson, Philip
    Sujet: Metaiodobenzylguanidine - Endothelial cell function - Biogenic amines
    Description: Radioiodinated metaiodobenzylguanidine (MIBG) has been shown to be extracted in the lung by an active, sodium-dependent, saturable transport system similar to that which extracts norepinephrine. Accordingly, first transit uptake of MIBG has been investigated as a method for in vivo evaluation of pulmonary biogenic amine metabolism. Issues that still must be resolved include the degree to which MIBG extraction is affected by simple loss of available vascular surface (in distinction to changes in amine metabolism). If MIBG lung extraction is altered by loss of pulmonary vascular surface alone, then a tracer must be found that can serve as a simultaneous monitor of vascular surface loss in order to allow normalization of the MIBG data. One tracer with such potential is radioiodinated iodoamphetamine (IMP). Accordingly, an experimental model of pulmonary vascular surface loss (lobar ligatures) was applied in an isolated-perfused lung model with simultaneous administration of MIBG and IMP. A linear relationship was found between MIBG extraction and percent lung surface loss by weight ( n =21, r =0.75, P 0.05). Addition of IMP (1 or 10 μM) to media containing MIBG (1 μM) ( n =28) inhibited overall MIBG extraction, but decreases in MIBG uptake with vascular surface loss were otherwise parallel to those in experiments without IMP. IMP, however, did not adequately reflect vascular surface loss at the concentrations used in this study (extraction of IMP 1 μM=31.2±12.9% in control vs 32.7%±7.7% with greater than 50% lung surface loss, n =18, P =NS). The results indicate that a correction for vascular surface loss is needed to interpret MIBG results in vivo, but suggest that IMP is not able to serve this purpose.
    Fait partie de: European Journal of Nuclear Medicine, 1989, Vol.15(4), pp.207-210
    Identifiant: 0340-6997 (ISSN); 1619-7089 (E-ISSN); 10.1007/BF00253797 (DOI)

  • Livre
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    Bone and tumors : Basle (Switzerland), November 4-7, 1979

    Donath, Alfred
    Genève : Ed. Médecine et hygiène
    1980
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    Titre: Bone and tumors : Basle (Switzerland), November 4-7, 1979 / ed. A. Donath, B. Courvoisier
    Auteur: Donath, Alfred
    Editeur: Genève : Ed. Médecine et hygiène
    Date: 1980
    Collation: 248 p. : ill. ; 24 cm
    Collection: Symposium CEMO ; 3
    Documents dans cette collection: Symposium Cemo
    Sujet MeSH: Bone Neoplasms - Congresses
    Note: Congrès de médecine. Basel. 1979
    No RERO: 0836159
    Permalien:
    http://data.rero.ch/01-0836159/html?view=GE_V1

  • Son
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    50 ans après Hiroshima, 10 ans après Tchernobyl : conséquences pour la santé ?

    Donath, Alfred
    Genève : Laboratoire audiovisuel universitaire [prod.]
    1997
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    Titre: 50 ans après Hiroshima, 10 ans après Tchernobyl [Enregistrement sonore] : conséquences pour la santé ? / Alfred Donath
    Auteur: Donath, Alfred
    Editeur: Genève : Laboratoire audiovisuel universitaire [prod.]
    Date: 1997
    Collation: 1 cassette sonore (75 min.)
    Note: Conférence de l'Université du 3ème âge. Section médicale - Donnée le 12 mars 1997
    Classification: meum médecine
    No RERO: R217473560
    Permalien:
    http://data.rero.ch/01-R217473560/html?view=GE_V1

  • Son
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    A la découverte du fonctionnement de notre cerveau

    Donath, Alfred
    Genève : Laboratoire audiovisuel universitaire [prod.]
    1985
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    Titre: A la découverte du fonctionnement de notre cerveau [Enregistrement sonore] / Alfred Donath
    Auteur: Donath, Alfred
    Editeur: Genève : Laboratoire audiovisuel universitaire [prod.]
    Date: 1985
    Collation: 1 CASSETTE SONORE (65 min.)
    Note: Conférence de l'Université du 3ème âge. Section médicale - Donnée le 13 novembre 1985
    Classification: meum biologie
    meum médecine
    No RERO: 0778788
    Permalien:
    http://data.rero.ch/01-0778788/html?view=GE_V1

  • Plusieurs versions

    Conséquences de l'accident de Tchernobyl sur la santé en Suisse et en URSS

    Donath, Alfred
  • Article
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    Beitrag der religiösen und kulturellen Traditionen zur Menschenrechtsbildung

    Donath, Alfred
    In: Menschenrechte und Bildung. - Bern : Stämpfli, 2006. - P. 135-138
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    Titre: Beitrag der religiösen und kulturellen Traditionen zur Menschenrechtsbildung / Alfred Donath
    Auteur: Donath, Alfred
    Sujet RERO: droits de l'homme - enseignement - Religion - Droit international - Judaïsme
    Publication en relation: In: Menschenrechte und Bildung. - Bern : Stämpfli, 2006. - P. 135-138
    Document hôte: Menschenrechte und Bildung
    Classification: dr-sys D 18 i
    dr-geubfd D 18 e MEBI 2006
    No RERO: R004382690
    Permalien:
    http://data.rero.ch/01-R004382690/html?view=GE_V1

  • Article
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    Lung uptake of 131 I-metaiodobenzylguanidine in sheep

    Slosman, Daniel, Morel, Denis, Mo Costabella, Pierre, Donath, Alfred
    European Journal of Nuclear Medicine, 1988, Vol.14(2), pp.65-70 [Revue évaluée par les pairs]
    Springer Science & Business Media B.V.
    Disponible
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    Titre: Lung uptake of 131 I-metaiodobenzylguanidine in sheep
    Auteur: Slosman, Daniel; Morel, Denis; Mo Costabella, Pierre; Donath, Alfred
    Sujet: Metaiodobenzylguanidine - Endothelial cell function - Biogenic amines
    Description: Circulating biogenic amines are known to be cleared by the mammalian lung. Their lung uptake is considered as an indicator of pulmonary endothelial integrity. Unfortunately, their use as markers of pulmonary metabolic function in human pathology is precluded by their biological effects and by the type of radiolabeling ( 3 H and 14 C), making them harmful for repeat injections and unfit for scintigraphy. Metaiodobenzylguanidine (MIBG) is structurally related to the neuron blocking agent guanethidine, devoid of significant biological effects, and has been shown to be extracted by the same active sodium dependent, saturable transport as norepinephrine in perfused rat lungs in vitro. We studied the single pass lung extraction of 131 I-MIBG in five awake and five anaesthetised sheep using the standard double indicator dilution technique with 99m Tc-human serum albumin (HSA) as an intravascular reference tracer. Intravenous bolus injection of increasing doses of MIBG up to 400 nmol resulted in a significant (F ratio=7.778, P
    Fait partie de: European Journal of Nuclear Medicine, 1988, Vol.14(2), pp.65-70
    Identifiant: 0340-6997 (ISSN); 1619-7089 (E-ISSN); 10.1007/BF00253443 (DOI)

  • Plusieurs versions

    Immunoscintigraphy with biosynthetically-labeled 75Se-antibodies—II. Comparison with antibodies labeled by radioiodination

    Ryser, Jean-Etienne, Carrel, Stefan, Buchegger, Franz, Donath, Alfred
    International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1990, Vol.17(5), pp.495-497