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    RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms

    Goncalves, Maria B, Moehlin, Julien, Clarke, Earl, Grist, John, Hobbs, Carl, Carr, Antony M, Jack, Julian, Mendoza-Parra, Marco Antonio, Corcoran, Jonathan P T
    iScience, 11 November 2019, Vol.21, pp.562-563
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Titre: RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms
    Auteur: Goncalves, Maria B; Moehlin, Julien; Clarke, Earl; Grist, John; Hobbs, Carl; Carr, Antony M; Jack, Julian; Mendoza-Parra, Marco Antonio; Corcoran, Jonathan P T
    Fait partie de: iScience, 11 November 2019, Vol.21, pp.562-563
    Identifiant: 2589-0042 (E-ISSN); 31726373 Version (PMID); 10.1016/j.isci.2019.10.068 (DOI)

    • Plusieurs versions

    RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms

    Goncalves, Maria B, Moehlin, Julien, Clarke, Earl, Grist, John, Hobbs, Carl, Carr, Antony M, Jack, Julian, Mendoza-Parra, Marco Antonio, Corcoran, Jonathan P T
    iScience, 25 October 2019, Vol.20, pp.554-566

    • Plusieurs versions

    Drug repurposing for Alzheimer's disease based on transcriptional profiling of human iPSC-derived cortical neurons

    Williams, Gareth, Gatt, Ariana, Clarke, Earl, Corcoran, Jonathan, Doherty, Patrick, Chambers, David, Ballard, Clive
    Translational psychiatry, 06 September 2019, Vol.9(1), pp.220 [Revue évaluée par les pairs]

    • Review
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    Combining Landsat and landscape metrics to analyse large-scale urban land cover change: a case study in the Jakarta Metropolitan Area

    Wahyudi, Agung, Liu, Yan, Corcoran, Jonathan
    Journal of Spatial Science, 02 September 2019, Vol.64(3), pp.515-534 [Revue évaluée par les pairs]
    Taylor & Francis (Taylor & Francis Group)
    Disponible
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    Titre: Combining Landsat and landscape metrics to analyse large-scale urban land cover change: a case study in the Jakarta Metropolitan Area
    Auteur: Wahyudi, Agung; Liu, Yan; Corcoran, Jonathan
    Sujet: Urban Land Cover Change ; Spatial Pattern ; Landscape Metrics ; Urban Growth ; Jakarta Metropolitan Area (Jma) ; Geography
    Description: This study tests the capacity of Landsat imagery and landscape metrics to explore spatial and temporal dynamics of urban expansion in Jakarta Metropolitan Area (JMA), Indonesia, over 23-year period (1994-2017). Results show that JMA's urban area has doubled in size with average expansion of nearly 40 km 2 per annum, and urban area has grown into sparsely vegetated areas on the outskirts of Jakarta and along the east-west and southern corridors of JMA. Landscape metrics show that urban land cover has evolved into single-connected urban landscape in JMA's core while more fragmented urban pattern in the inner and outer municipalities.
    Fait partie de: Journal of Spatial Science, 02 September 2019, Vol.64(3), pp.515-534
    Identifiant: 1449-8596 (ISSN); 1836-5655 (E-ISSN); 10.1080/14498596.2018.1443849 (DOI)

    • Plusieurs versions

    Corrigendum to "Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury" Bioorg. Med. Chem. Lett. 29(8) (2019) 995-1000

    Goncalves, Maria B, Clarke, Earl, Jarvis, Christopher I, Kalindjian, S Barret, Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T, Mills, Mark, Mumford, Peter, Borthwick, Alan D, Corcoran, Jonathan P T
    Bioorganic & medicinal chemistry letters, 15 August 2019, Vol.29(16), pp.2440-2441 [Revue évaluée par les pairs]

    • Plusieurs versions

    The influence of weather conditions on adult transit ridership in the sub-tropics

    Wei, Ming, Liu, Yan, Sigler, Thomas, Liu, Xiaoyang, Corcoran, Jonathan
    Transportation Research Part A, July 2019, Vol.125, pp.106-118 [Revue évaluée par les pairs]

    • Plusieurs versions

    Weather and cycling in New York: The case of Citibike

    An, Ran, Zahnow, Renee, Pojani, Dorina, Corcoran, Jonathan
    Journal of Transport Geography, May 2019, Vol.77, pp.97-112 [Revue évaluée par les pairs]

    • Article
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    Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells

    Goncalves, Maria B, Wu, Yue, Clarke, Earl, Grist, John, Hobbs, Carl, Trigo, Diogo, Jack, Julian, Corcoran, Jonathan P T
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 17 April 2019, Vol.39(16), pp.3013-3027 [Revue évaluée par les pairs]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Titre: Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells
    Auteur: Goncalves, Maria B; Wu, Yue; Clarke, Earl; Grist, John; Hobbs, Carl; Trigo, Diogo; Jack, Julian; Corcoran, Jonathan P T
    Sujet: Ng2+ Cells ; Rarα ; Rarβ ; Decorin ; Exosome ; Myelination ; Retinoic Acid
    Description: In the CNS, oligodendrocytes are responsible for myelin formation and maintenance. Following spinal cord injury, oligodendrocyte loss and an inhibitory milieu compromise remyelination and recovery. Here, we explored the role of retinoic acid receptor-beta (RARβ) signaling in remyelination. Using a male Sprague Dawley rat model of PNS-CNS injury, we show that oral treatment with a novel drug like RARβ agonist, C286, induces neuronal expression of the proteoglycan decorin and promotes myelination and differentiation of oligodendrocyte precursor cells (NG2 cells) in a decorin-mediated neuron-glia cross talk. Decorin promoted the activation of RARα in NG2 cells by increasing the availability of the endogenous ligand RA. NG2 cells synthesize RA, which is released in association with exosomes. We found that decorin prevents this secretion through regulation of the EGFR-calcium pathway. Using functional and pharmacological studies, we further show that RARα signaling is both required and sufficient for oligodendrocyte differentiation. These findings illustrate that RARβ and RARα are important regulators of oligodendrocyte differentiation, providing new targets for myelination. This study identifies novel therapeutic targets for remyelination after PNS-CNS injury. Pharmacological and knock-down experiments show that the retinoic acid (RA) signaling promotes differentiation of oligodendrocyte precursor cells (OPCs) and remyelination in a cross talk between neuronal RA receptor-beta (RARβ) and RARα in NG2 cells. We show that stimulation of RARα is required for the differentiation of OPCs and we describe for the first time how oral treatment with a RARβ agonist (C286, currently being tested in a Phase 1 trial, ISRCTN12424734) leads to the endogenous synthesis of RA through retinaldehyde dehydrogenase 2 (Raldh2) in NG2 cells and controls exosome-associated-RA intracellular levels through a decorin-Ca pathway. Although RARβ has been implicated in distinct aspects of CNS regeneration, this study identifies a novel function for both RARβ and RARα in remyelination.
    Fait partie de: The Journal of neuroscience : the official journal of the Society for Neuroscience, 17 April 2019, Vol.39(16), pp.3013-3027
    Identifiant: 1529-2401 (E-ISSN); 30760627 Version (PMID); 10.1523/JNEUROSCI.2922-18.2019 (DOI)

    • Article
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    Modelling the spatial dynamics of Mainland China-born migrants in Australia

    Wang, Siqin, Sigler, Thomas, Corcoran, Jonathan, Liu, Yan
    Australian Geographer, 03 April 2019, Vol.50(2), pp.201-219 [Revue évaluée par les pairs]
    Taylor & Francis (Taylor & Francis Group)
    Disponible
    Plus…
    Titre: Modelling the spatial dynamics of Mainland China-born migrants in Australia
    Auteur: Wang, Siqin; Sigler, Thomas; Corcoran, Jonathan; Liu, Yan
    Sujet: MC-Born Migrant ; Ethnic Concentration ; Geographically Weighted Regression ; Spatial Evolution ; Residential Pattern ; Australia ; Geography ; History & Archaeology
    Description: Over the past two decades, migration from Mainland China (MC) to Australia has become increasingly significant. In contrast to previous migrant waves, post-2000 MC-born migrants in Australia are more likely to be highly skilled and/or financially...
    Fait partie de: Australian Geographer, 03 April 2019, Vol.50(2), pp.201-219
    Identifiant: 0004-9182 (ISSN); 1465-3311 (E-ISSN); 10.1080/00049182.2018.1508542 (DOI)

    • Plusieurs versions

    Community social capital and individual functioning in the post-disaster context

    Zahnow, Renee, Wickes, Rebecca, Taylor, Mel, Corcoran, Jonathan
    Disasters, April 2019, Vol.43(2), pp.261-288 [Revue évaluée par les pairs]