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    • Article
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    Severe immune-related hepatitis induced by immune checkpoint inhibitors: Clinical features and management proposal

    Gauci, Marie-Léa, Baroudjian, Barouyr, Bédérède, Ulysse, Zeboulon, Charlotte, Delyon, Julie, Allayous, Clara, Madelaine, Isabelle, Eftekhari, Pirayeh, Resche-Rigon, Matthieu, Poté, Nicolas, Paradis, Valerie, Durand, François, Lebbé, Céleste
    Clinics and research in hepatology and gastroenterology, 06 August 2020 [Revue évaluée par les pairs]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Titre: Severe immune-related hepatitis induced by immune checkpoint inhibitors: Clinical features and management proposal
    Auteur: Gauci, Marie-Léa; Baroudjian, Barouyr; Bédérède, Ulysse; Zeboulon, Charlotte; Delyon, Julie; Allayous, Clara; Madelaine, Isabelle; Eftekhari, Pirayeh; Resche-Rigon, Matthieu; Poté, Nicolas; Paradis, Valerie; Durand, François; Lebbé, Céleste
    Sujet: Cancer ; Immune-Related Adverse Events ; Immune-Related Hepatitis ; Immunotherapy ; Ipilimumab ; Melanoma
    Description: Immune-related hepatitis (IRH) occurs in 1 to 18% of immune checkpoint inhibitor (ICI)-treated patients. Steroids are usually recommended for grade≥3 IRH, but their impact on IRH resolution and patient survival remains unclear. We retrospectively analyzed a prospective cohort of 339 patients treated at Saint-Louis Hospital (Paris, France) with ICIs for advanced melanoma. Cases of grade≥3 IRH were collected and analyzed. Two groups were compared for their biological features and time for IRH resolution and survival: patients who received steroids (steroids group: SG) and patients who did not (nonsteroids group: NSG). Grade≥3 IRH was observed in 21 patients. Thirteen were treated with steroids (SG), and 8 were not (NSG). The median time for toxicity resolution was 49 days in SG and 24 days in NSG (P=0.62). All but one patient showed a favorable outcome. Two-year survival was 56% in SG and 54% in NSG (P=0.83). Higher transaminase (P=0.002) and bilirubin (P=0.008) and lower prothrombin (P=0.035) levels were observed in SG than in NSG. For 8 (4 SG/4 NSG) patients, ICI was resumed without any hepatitis relapse. Favorable outcomes may be achieved spontaneously and with no steroids in patients with severe IRH. Steroid initiation should be discussed in cases of high bilirubin levels and decreased prothrombin levels. ICI could be resumed without hepatitis relapse. We propose a management algorithm for grade≥3 IRH that should be validated in larger and prospective cohorts.
    Fait partie de: Clinics and research in hepatology and gastroenterology, 06 August 2020
    Identifiant: 2210-741X (E-ISSN); 32773362 Version (PMID); 10.1016/j.clinre.2020.06.016 (DOI)

    • Plusieurs versions

    Cancer, immune suppression and Coronavirus Disease-19 (COVID-19): Need to manage drug safety (French Society for Oncology Pharmacy [SFPO] guidelines)

    Slimano, Florian, Baudouin, Amandine, Zerbit, Jérémie, Toulemonde-Deldicque, Anne, Thomas-Schoemann, Audrey, Chevrier, Régine, Daouphars, Mikaël, Madelaine, Isabelle, Pourroy, Bertrand, Tournamille, Jean-François, Astier, Alain, Ranchon, Florence, Cazin, Jean-Louis, Bardin, Christophe, Rioufol, Catherine
    Cancer treatment reviews, August 2020, Vol.88 [Revue évaluée par les pairs]

    • Article
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    Complement C5 inhibition in patients with COVID-19 - a promising target?

    Peffault De Latour, Regis, Bergeron, Anne, Lengline, Etienne, Dupont, Thibault, Marchal, Armance, Galicier, Lionel, De Castro, Nathalie, Bondeelle, Louise, Darmon, Michael, Dupin, Clairelyne, Dumas, Guillaume, Leguen, Pierre, Madelaine, Isabelle, Chevret, Sylvie, Molina, Jean-Michel, Azoulay, Elie, Fremeaux-Bacchi, Veronique
    Haematologica, 23 July 2020 [Revue évaluée par les pairs]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Titre: Complement C5 inhibition in patients with COVID-19 - a promising target?
    Auteur: Peffault De Latour, Regis; Bergeron, Anne; Lengline, Etienne; Dupont, Thibault; Marchal, Armance; Galicier, Lionel; De Castro, Nathalie; Bondeelle, Louise; Darmon, Michael; Dupin, Clairelyne; Dumas, Guillaume; Leguen, Pierre; Madelaine, Isabelle; Chevret, Sylvie; Molina, Jean-Michel; Azoulay, Elie; Fremeaux-Bacchi, Veronique
    Sujet: Cell Therapy and Immunotherapy ; Infectious Disorders ; Complement
    Fait partie de: Haematologica, 23 July 2020
    Identifiant: 1592-8721 (E-ISSN); 32703791 Version (PMID); 10.3324/haematol.2020.260117 (DOI)

    • Article
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    Improved time to treatment failure and survival in ibrutinib-treated malignancies with a pharmaceutical care program: an observational cohort study

    Zerbit, Jeremie, Chevret, Sylvie, Bernard, Sophie, Kroemer, Marie, Ablard, Charlotte, Harel, Stephanie, Brice, Pauline, Madelaine, Isabelle, Thieblemont, Catherine
    Annals of hematology, July 2020, Vol.99(7), pp.1615-1625 [Revue évaluée par les pairs]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Titre: Improved time to treatment failure and survival in ibrutinib-treated malignancies with a pharmaceutical care program: an observational cohort study
    Auteur: Zerbit, Jeremie; Chevret, Sylvie; Bernard, Sophie; Kroemer, Marie; Ablard, Charlotte; Harel, Stephanie; Brice, Pauline; Madelaine, Isabelle; Thieblemont, Catherine
    Sujet: Education ; Ibrutinib ; Leukemia ; Lymphoma ; Pharmacist ; Survival ; Quality Improvement ; Neoplasms -- Drug Therapy ; Pharmaceutical Services -- Standards ; Pyrazoles -- Therapeutic Use ; Pyrimidines -- Therapeutic Use ; Time-to-Treatment -- Standards
    Description: Ibrutinib treatment has been shown to increase survival in patients with B cell malignancies. Real-life data suggest a large part of discontinuations are due to toxicities, impairing ibrutinib efficacy. We aimed to assess the impact of a pharmaceutical care program on the efficacy and safety of ibrutinib. This single-center, cohort, observational study enrolled patients with B cell malignancies. Patients were either assigned to the program or to receive usual care, based on physician decision. The program was conducted by clinical pharmacists specializing in oncology and included patient education for management of toxicities, adherence monitoring, interventions to reduce drug-drug interactions, and follow-up of transition from hospital to community. Between February 2014 and May 2017, we enrolled 155 patients, including 42 (27%) who were allocated to the program group and 113 (73%) to the usual care group. The effect of the program was beneficial in terms of time to treatment failure (p...
    Fait partie de: Annals of hematology, July 2020, Vol.99(7), pp.1615-1625
    Identifiant: 1432-0584 (E-ISSN); 32483668 Version (PMID); 10.1007/s00277-020-04045-y (DOI)

    • Film
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    C'est ça l'amour

    Burger, Claire, Madelaine, Isabelle
    [Paris] : Blaq out
    [2019]
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    Titre: C'est ça l'amour / un film de Claire Burger ; produit par Isabelle Madelaine
    Auteur: Burger, Claire; Madelaine, Isabelle
    Editeur: [Paris] : Blaq out
    Date: [2019]
    Collation: 1 DVD-vidéo
    Sujet RERO - forme: [Comédies dramatiques (cinéma)]
    Description: Depuis que sa femme est partie, Mario tient la maison et élève seul ses deux filles. Frida, 14 ans, lui reproche le départ de sa mère et Niki, 17 ans, rêve d'indépendance. Mario, lui, attend toujours le retour de sa femme. (www.filmages.ch)
    Public cible: Dès 16 ans
    Interprètes: Bouli Lanners, Justine Lacroix, Sarah Henochsberg ... et al.
    Note: Langues: Français. Sous-titres pour sourds et malentendants. Audiodescription - Durée du film : 94 min. - Une prod. : Dharamsala - Arte, 2019
    Classification: nefian Drame
    No RERO: R008957346
    Permalien:
    http://data.rero.ch/01-R008957346/html?view=NJ_V1

    • Plusieurs versions

    Low-dose ritonavir-boosted darunavir in virologically suppressed HIV-1-infected adults: an open-label trial (ANRS 165 Darulight)

    Molina, Jean-Michel, Gallien, Sebastien, Chaix, Marie-Laure, El Abbassi, El Mountacer, Madelaine, Isabelle, Katlama, Christine, Valin, Nadia, Delobel, Pierre, Desseaux, Kristell, Peytavin, Gilles, Saillard, Juliette, Raffi, François, Chevret, Sylvie
    The Journal of antimicrobial chemotherapy, 01 August 2018, Vol.73(8), pp.2129-2136 [Revue évaluée par les pairs]

    • Plusieurs versions

    Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome induced by nivolumab

    Gauci, Marie-Léa, Baroudjian, Barouyr, Laly, Pauline, Madelaine, Isabelle, Da Meda, Laetitia, Vercellino, Laetitia, Bagot, Martine, Lioté, Frédéric, Pages, Cécile, Lebbé, Céleste
    Seminars in arthritis and rheumatism, October 2017, Vol.47(2), pp.281-287 [Revue évaluée par les pairs]

    • Film
    Sélectionner

    Maryland

    Winocour, Alice, 1976-, Gesaffelstein, 1985-, Bron, Jean-Stéphane, Madelaine, Isabelle
    [Paris] : Ed. vidéo France Télévisions Distribution
    2016
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    Titre: Maryland / un film de Alice Winocour ; musique Gesaffelstein ; scénario Alice Winocour ; avec la collab. de Jean-Stéphane Bron ; prod. par Isabelle Madelaine et Emilie Tisné
    Auteur: Winocour, Alice, 1976-; Gesaffelstein, 1985-; Bron, Jean-Stéphane; Madelaine, Isabelle
    Editeur: [Paris] : Ed. vidéo France Télévisions Distribution
    Date: 2016
    Collation: 1 DVD-vidéo
    Description: De retour du combat, Vincent, victime de troubles de stress post-traumatique, est chargé d'assurer la sécurité de Jessie, la femme d'un riche homme d'affaires libanais, dans sa propriété "Maryland". Tandis qu'il éprouve une étrange fascination pour la femme qu'il doit protéger, Vincent est sujet à des angoisses et des hallucinations. Malgré le calme apparent qui règne sur "Maryland", Vincent perçoit une menace extérieure...
    Drame
    Thriller
    Public cible: Dès 16 ans
    Interprètes: Matthias Schoenaerts ; Diane Kruger ; Paul Lamy ; Zaïd Errougui-Demonsant ; Percy Kemp ... et al.
    Note: Une prod.: Dharamsala - Darius Films - Mars Films - France 3 Cinéma - Scope Pictures, 2015 - Durée du film: ca. 99 min. - Langues: Français. Sous-titres: Français pour sourds et malentendants
    Note: Image George Lechaptois ; montage Julien Lacheray
    Classification: njhepg drame : forme
    No RERO: R008386568
    Permalien:
    http://data.rero.ch/01-R008386568/html?view=NJ_V1

    • Plusieurs versions

    Single-center study under a French Temporary Authorization for Use (TAU) protocol for ipilimumab in metastatic melanoma: negative impact of baseline corticosteroids

    Chasset, François, Pages, Cécile, Biard, Lucie, Roux, Jennifer, Sidina, Irina, Madelaine, Isabelle, Basset-Seguin, Nicole, Viguier, Manuelle, Madjlessi-Ezra, Nika, Schneider, Pierre, Bagot, Martine, Resche-Rigon, Matthieu, Lebbe, Céleste
    European journal of dermatology : EJD, 2015, Vol.25(1), pp.36-44 [Revue évaluée par les pairs]

    • Plusieurs versions

    Pegylated liposomal doxorubicin: an efficient treatment in patients with Hodgkin lymphoma relapsing after high dose therapy and stem cell transplation

    Clozel, Thomas, Deau, Benedicte, Benet, Claire, Franchi, Patricia, Robin, Marie, Madelaine, Isabelle, Thieblemont, Catherine, De Kerviler, Eric, Brière, Josette, Brice, Pauline
    British journal of haematology, September 2013, Vol.162(6), pp.846-8 [Revue évaluée par les pairs]