Livre

Characterization of a new response to bacterial pore-forming toxin that promotes cell survival in a caspase-1 dependent activation of SREBPs / Laure Gurcel…

Disponible
Titre
Characterization of a new response to bacterial pore-forming toxin that promotes cell survival in a caspase-1 dependent activation of SREBPs / Laure Gurcel
Auteur
Editeur
Genève : [s.n.]
Date
2006
Collation
134 p. : ill. ; 30 cm
Sujet MeSH
Description
Many pathogenic organisms produce poreforming toxins as virulence factors. Target cells however mount a response to such membrane damage. Here we show that toxin-induced membrane permeabilization leads to a decrease in cytoplasmic potassium, which promotes the formation of a multiprotein oligomeric innate immune complex, called the inflammasome, and the activation of caspase-1. Further, we find that when rendered proteolytic in this context caspase-1 induces the activation of the central regulators of membrane biogenesis, the Sterol Regulatory Element Binding Proteins (SREBPs), which in turn promote cell survival upon toxin challenge possibly by facilitating membrane repair. This study highlights that, in addition to its well-established role in triggering inflammation via the processing of the precursor forms of interleukins, caspase-1 has a broader role, in particular linking the intracellular ion composition to lipid metabolic pathways, membrane biogenesis, and survival
Note
Texte en anglais avec résumé en français - Th. Univ. Genève, 2006 ; Sc. 3801 - Existe aussi en version électronique
Note
Directrice de thèse: Professeure Françoise Gisou Van der Goot ; codirecteur: Professeur Jean Gruenberg
No RERO
R004294194
Permalien
http://data.rero.ch/01-R004294194/html