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Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis
Carbajal, Kevin S, Schaumburg, Christopher, Strieter, Robert, Kane, Joy, Lane, Thomas E
Proceedings of the National Academy of Sciences of the United States of America, 15 June 2010, Vol.107(24), pp.11068-73
[Revue évaluée par les pairs]
Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis
Muse, Michael, Kane, Joy A.C, Carr, Daniel J.J, Farber, Joshua M, Lane, Thomas E
Virology (New York, N.Y.), 2008, Vol.382(2), pp.132-144
[Revue évaluée par les pairs]
Titre: Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis Auteur:Muse, Michael; Kane, Joy Ac; Carr, Daniel Jj; Farber, Joshua M; Lane, Thomas E Sujet:Liver ; Brain ; Killer Cells ; Natural ; Animals ; Mice ; Inbred C57bl ; Mice ; Knockout ; Mice ; Murine Hepatitis Virus ; Encephalitis ; Viral ; Hepatitis ; Viral ; Animal ; Coronavirus Infections ; Homeodomain Proteins ; Virus Replication ; Recombination Description:
The role of the CXC chemokine ligand 9 (CXCL9) in host defense following infection with mouse hepatitis virus (MHV) was determined. Inoculation of the central nervous system (CNS) of CXCL9-/- mice with MHV resulted in accelerated and increased mortality compared to wild type mice supporting an important role for CXCL9 in anti-viral defense. In addition, infection of RAG1-/- or CXCL9-/- mice with a recombinant MHV expressing CXCL9 (MHV-CXCL9) resulted in protection from disease that correlated with reduced viral titers within the brain and NK cell-mediated protection in the liver. Survival in MHV-CXCL9-infected CXCL9-/- mice was associated with reduced viral burden within the brain that coincided with increased T cell infiltration. Similarly, viral clearance from the livers of MHV-CXCL9-infected mice was accelerated but independent of increased T cell or NK cell infiltration. These observations indicate that CXCL9 promotes protection from coronavirus-induced neurological and liver...