Maintenance: Dimanche 8 décembre : le catalogue sera accessible uniquement en mode consultation (pas de demandes en ligne ni d'accès au dossier lecteur).
Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis
Carbajal, Kevin S, Schaumburg, Christopher, Strieter, Robert, Kane, Joy, Lane, Thomas E
Proceedings of the National Academy of Sciences of the United States of America, 15 June 2010, Vol.107(24), pp.11068-73
[Revue évaluée par les pairs]
Muse, Michael, Kane, Joy A C, Carr, Daniel J J, Farber, Joshua M, Lane, Thomas E
Virology, 20 December 2008, Vol.382(2), pp.132-44
[Revue évaluée par les pairs]
MEDLINE/PubMed (U.S. National Library of Medicine)
Titre: Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis Auteur:Muse, Michael; Kane, Joy A C; Carr, Daniel J J; Farber, Joshua M; Lane, Thomas E Sujet:Chemokine Cxcl9 -- Genetics ; Coronavirus Infections -- Prevention & Control ; Encephalitis, Viral -- Prevention & Control ; Hepatitis, Viral, Animal -- Prevention & Control ; Murine Hepatitis Virus -- Genetics Description:
The role of the CXC chemokine ligand 9 (CXCL9) in host defense following infection with mouse hepatitis virus (MHV) was determined. Inoculation of the central nervous system (CNS) of CXCL9-/- mice with MHV resulted in accelerated and increased mortality compared to wild type mice supporting an important role for CXCL9 in anti-viral defense. In addition, infection of RAG1-/- or CXCL9-/- mice with a recombinant MHV expressing CXCL9 (MHV-CXCL9) resulted in protection from disease that correlated with reduced viral titers within the brain and NK cell-mediated protection in the liver. Survival in MHV-CXCL9-infected CXCL9-/- mice was associated with reduced viral burden within the brain that coincided with increased T cell infiltration. Similarly, viral clearance from the livers of MHV-CXCL9-infected mice was accelerated but independent of increased T cell or NK cell infiltration. These observations indicate that CXCL9 promotes protection from coronavirus-induced neurological and liver disease.
Fait partie de:
Virology, 20 December 2008, Vol.382(2), pp.132-44
Identifiant:
1096-0341 (E-ISSN); 18973912 Version (PMID); 10.1016/j.virol.2008.09.032 (DOI)