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    Le balcon sous le ciel

    Denier, Charles, 1894-1972
    Lausanne : G. Chappuis
    1929
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    Titre: Le balcon sous le ciel / Charles Denier
    Auteur: Denier, Charles, 1894-1972
    Edition: 2e éd.
    Editeur: Lausanne : G. Chappuis
    Date: 1929
    Collation: 1 vol. (non paginé) ; 19 cm
    No RERO: 0279063
    Permalien:
    http://data.rero.ch/01-0279063/html?view=VS_V1

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    L'étreinte : roman de Jean-Marie et Valentine

    Denier, Charles, 1894-1972
    Lausanne
    1928
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    Titre: L'étreinte : roman de Jean-Marie et Valentine / Ch. Denier
    Auteur: Denier, Charles, 1894-1972
    Editeur: Lausanne
    Date: 1928
    Collation: 153 p. ; 8⁰
    No RERO: 0279064
    Permalien:
    http://data.rero.ch/01-0279064/html?view=VS_V1

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    Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature

    Fouillade, Charles, Baron-Menguy, Céline, Domenga-Denier, Valérie, Thibault, Christelle, Takamiya, Kogo, Huganir, Richard, Joutel, Anne
    Arteriosclerosis, thrombosis, and vascular biology, January 2013, Vol.33(1), pp.76-86 [Revue évaluée par les pairs]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Titre: Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature
    Auteur: Fouillade, Charles; Baron-Menguy, Céline; Domenga-Denier, Valérie; Thibault, Christelle; Takamiya, Kogo; Huganir, Richard; Joutel, Anne
    Sujet: Vasoconstriction ; Carrier Proteins -- Metabolism ; Muscle, Smooth, Vascular -- Metabolism ; Myocytes, Smooth Muscle -- Metabolism ; Nerve Tissue Proteins -- Metabolism ; Receptors, Notch -- Metabolism
    Description: Notch3 is critically important for the structure and myogenic response of distal arteries, particularly of cerebral arteries. However, signaling pathways acting downstream of Notch3 remain largely unknown. Transcriptome analysis using tail arteries of Notch3-null mice identified a core set of 17 novel Notch3-regulated genes confirmed in tail or brain arteries. Postnatal deletion of RBP-Jκ in smooth muscle cells recapitulated the structural, functional, and molecular defects of brain arteries induced by Notch3 deficiency. Transient in vivo blockade of the Notch pathway with γ-secretase inhibitors uncovered, in addition to Notch3, 6 immediate responders, including the voltage-gated potassium channel Kv1.5, which opposes to myogenic constriction of brain arteries, and the glutamate receptor-interacting protein 2 (Grip2) with no previously established role in the cerebrovasculature. We identified a vascular smooth muscle cell isoform of Grip2. We showed that Notch3-RBP-Jκ specifically regulates this isoform. Finally, we found that cerebral arteries of Grip2 mutant mice, which express an N-terminally truncated Grip2 protein, exhibited selective attenuation of pressure-induced contraction. Our data provide insight into how Notch3 signals in the brain arteries, establishing the postnatal requirement of smooth muscle RBP-Jκ in this context. Notch3-regulated transcriptome provides potential for modulating myogenic response in the cerebrovasculature.
    Fait partie de: Arteriosclerosis, thrombosis, and vascular biology, January 2013, Vol.33(1), pp.76-86
    Identifiant: 1524-4636 (E-ISSN); 23117660 Version (PMID); 10.1161/ATVBAHA.112.251736 (DOI)

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    Archetypal Arg169Cys mutation in NOTCH3 does not drive the pathogenesis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy via a loss-of-function mechanism

    Cognat, Emmanuel, Baron-Menguy, Céline, Domenga-Denier, Valérie, Cleophax, Sabine, Fouillade, Charles, Monet-Leprêtre, Marie, Dewerchin, Mieke, Joutel, Anne
    Stroke, March 2014, Vol.45(3), pp.842-9 [Revue évaluée par les pairs]
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    Titre: Archetypal Arg169Cys mutation in NOTCH3 does not drive the pathogenesis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy via a loss-of-function mechanism
    Auteur: Cognat, Emmanuel; Baron-Menguy, Céline; Domenga-Denier, Valérie; Cleophax, Sabine; Fouillade, Charles; Monet-Leprêtre, Marie; Dewerchin, Mieke; Joutel, Anne
    Sujet: Cadasil ; Notch3 Protein, Mouse ; Etiology ; Mouse Models ; Cadasil -- Genetics ; Mutation -- Genetics ; Receptors, Notch -- Genetics
    Description: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy, the most common heritable small vessel disease of the brain, is caused by dominant mutations in the NOTCH3 receptor that stereotypically lead to age-dependent Notch3ECD deposition in the vessels. NOTCH3 loss of function has been demonstrated for few mutations. However, whether this finding applies to all mutations and whether a loss-of-function mechanism drives the manifestations of the disease remain yet unknown. This study investigated the in vivo functionality of the Arg169Cys archetypal mutation. We used mice with constitutive or conditional reduction of NOTCH3 activity, mice harboring the Arg169Cys mutation at the endogenous Notch3 locus (Notch3Arg170Cys), and mice overexpressing the Arg169Cys NOTCH3 mutant (TgPAC-Notch3R169C) on either a Notch3 wild-type or a null background. NOTCH3 activity was monitored in the brain arteries by measuring the expression of NOTCH3 target genes using real-time polymerase chain reaction. Notch3ECD deposits were assessed by immunohistochemistry. Brain parenchyma was analyzed for vacuolation and myelin debris in the white matter and infarcts. We identified a subset of genes appropriate to detect NOTCH3 haploinsufficiency in the adult. Expression of these genes was unaltered in Notch3Arg170Cys mice, despite marked Notch3ECD deposits. Elimination of wild-type NOTCH3 did not influence the onset and burden of white matter lesions in 20-month-old TgPAC-Notch3R169C mice, and 20-month-old Notch3-null mice exhibited neither infarct nor white matter changes. These data provide strong evidence that cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy can develop without impairment of NOTCH3 signaling and argue against a loss of NOTCH3 function as a general driving mechanism for white matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy.
    Fait partie de: Stroke, March 2014, Vol.45(3), pp.842-9
    Identifiant: 1524-4628 (E-ISSN); 24425116 Version (PMID); 10.1161/STROKEAHA.113.003339 (DOI)

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    CT venous phase venography with 64-detector CT angiography in the diagnosis of acute pulmonary embolism

    Stein, Paul D, Matta, Fadi, Yaekoub, Abdo Y, Kazerooni, Ella A, Cahill, Jennifer Ellis, Goodman, Lawrence R, Sostman, H Dirk, Hales, Charles A, Denier, James E, Weg, John G, Ghumman, Dilraj, Chan, Kevin M, Woodard, Pamela K, Kwun, Yoojin
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, August 2010, Vol.16(4), pp.422-9 [Revue évaluée par les pairs]
    MEDLINE/PubMed (U.S. National Library of Medicine)
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    Titre: CT venous phase venography with 64-detector CT angiography in the diagnosis of acute pulmonary embolism
    Auteur: Stein, Paul D; Matta, Fadi; Yaekoub, Abdo Y; Kazerooni, Ella A; Cahill, Jennifer Ellis; Goodman, Lawrence R; Sostman, H Dirk; Hales, Charles A; Denier, James E; Weg, John G; Ghumman, Dilraj; Chan, Kevin M; Woodard, Pamela K; Kwun, Yoojin
    Sujet: Angiography -- Methods ; Pulmonary Embolism -- Diagnostic Imaging ; Tomography, X-Ray Computed -- Methods ; Venous Thrombosis -- Diagnostic Imaging
    Description: The value of computed tomographic (CT) venography in combination with CT pulmonary angiography has been questioned because of the potential dangers of radiation. Accordingly, we retrospectively evaluated the diagnostic yield of 64-detector CT angiography with CT venography. Among patients who routinely underwent CT venography with CT angiography, the CT angiogram showed acute pulmonary embolism (PE) in 206 of 1903 patients (10.8%). A positive CT venogram in a patient with a negative CT angiogram was shown in 25 of 1903 patients (1.3%). Either the CT angiogram or the CT venogram showed venous thromboembolism in 231 of 1903 patients (12.1%). The proportion of patients with venous thromboembolism diagnosed only by a CT venogram was 25 of 231 (10.8%). In conclusion, the proportion of patients with venous thromboembolism diagnosed only by a CT venogram is sufficiently high to merit consideration of its use especially in those at high risk for DVT.
    Fait partie de: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, August 2010, Vol.16(4), pp.422-9
    Identifiant: 1938-2723 (E-ISSN); 19520677 Version (PMID); 10.1177/1076029609335502 (DOI)