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    Reappraisal of the interplay between psychosis and depression symptoms in the pathogenesis of psychotic syndromes: results from a twenty-year prospective community study

    Rössler, Wulf, Angst, Jules, Gamma, Alex, Haker, Helene, Stulz, Niklaus, Merikangas, Kathleen, Ajdacic-Gross, Vladeta
    European Archives of Psychiatry and Clinical Neuroscience, 2011, Vol.261(1), pp.11-19 [Revue évaluée par les pairs]

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    Reappraisal of the interplay between psychosis and depression symptoms in the pathogenesis of psychotic syndromes: results from a twenty-year prospective community study

    Rössler, Wulf
    Angst, Jules, Gamma, Alex, Haker, Helene, Stulz, Niklaus, Merikangas, Kathleen, Ajdacic-Gross, Vladeta
    European Archives of Psychiatry and Clinical Neuroscience. - 2011/261/1/11-19
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    Titre: Reappraisal of the interplay between psychosis and depression symptoms in the pathogenesis of psychotic syndromes: results from a twenty-year prospective community study
    Auteur: Rössler, Wulf
    Contributeur: Angst, Jules; Gamma, Alex; Haker, Helene; Stulz, Niklaus; Merikangas, Kathleen; Ajdacic-Gross, Vladeta
    Sujet: Subclinical psychosis - Schizotypy - Schizotypal personality disorder - Depression - Community study - Epidemiological cohort
    Description: The interplay of psychotic and affective symptoms is a crucial challenge in understanding the pathogenesis of psychosis. In this study, we analyzed the interplay between two subclinical psychosis symptoms dimensions, and one depression symptoms dimension, using longitudinal data from Zurich. The Zurich study started in 1979 with a representative sample of 591 participants who were aged 20/21. Follow-up interviews were conducted at age 23, 28, 30, 35, and 41. The psychiatric symptoms were assessed with a semi-structured interview and the SCL 90-R. In this study, we analyzed three SCL-90-R subscales: the depression symptoms dimension and two distinct symptoms dimensions of subclinical psychosis, one representing a schizophrenia nuclear symptom dimension, the other representing a schizotypal symptoms dimension. Modeling was done with hybrid latent growth models, thereby including simultaneous and cross-lagged effects. The interplay between the two subclinical psychosis symptoms dimensions and the depression symptoms dimension includes several intertwined pathways. The schizotypal symptoms dimension has strong direct effects on the schizophrenia nuclear symptoms dimension, but also on the depression symptoms dimension. The latter has for its part an effect on the schizophrenia nuclear symptoms dimension. The main driving force within the dynamic interplay between depression and psychosis symptoms is a schizotypal symptoms dimension, which represents social and interpersonal deficiencies, ideas of reference, suspiciousness, paranoid ideation, and odd behavior. It does not only directly influence subclinical nuclear schizophrenia symptoms but also the symptoms of depression
    Publication en relation: European Archives of Psychiatry and Clinical Neuroscience. - 2011/261/1/11-19
    Document hôte: European Archives of Psychiatry and Clinical Neuroscience
    Identifiant: 10.1007/s00406-010-0123-0 (DOI)