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    Is depression a risk factor for heart complaints?

    Eich, Dominique, Neuhaus, Christoph, Gamma, Alex, Angst, Jules, Rössler, Wulf, Ajdacic-Gross, Vladeta, Opravil, Milos
    European Archives of Psychiatry and Clinical Neuroscience, 2007, Vol.257(7), pp.396-401 [Revue évaluée par les pairs]

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    Is depression a risk factor for heart complaints? Longitudinal aspects in the Zurich study

    Eich, Dominique
    Neuhaus, Christoph, Gamma, Alex, Angst, Jules, Rössler, Wulf, Ajdacic-Gross, Vladeta, Opravil, Milos
    European Archives of Psychiatry and Clinical Neuroscience. - 2007/257/7/396-401
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    Titre: Is depression a risk factor for heart complaints? Longitudinal aspects in the Zurich study
    Auteur: Eich, Dominique
    Contributeur: Neuhaus, Christoph; Gamma, Alex; Angst, Jules; Rössler, Wulf; Ajdacic-Gross, Vladeta; Opravil, Milos
    Sujet: epidemiology - heart complaints - major depression - minor depression - recurrent brief depression
    Description: Background: The objective of this longitudinal study was to assess the association between major depression and heart complaints in a population of young and healthy adults. Methods: Starting at the age 20/21, participants of the Zurich Study underwent 6 structured, psychological interviews during a span of 20years. We evaluated longitudinal data from 277 persons who participated in all 6 interviews including questions about heart complaints. Results: Over 20years, heart complaints were reported by two thirds of participants, and the frequency of depression was 11.4%. At the age of 40/41, heart complaints were significantly associated with earlier heart complaints and major depression, both more often in women. Recurrent brief depression showed a tendency, but neither minor depression nor depressive symptoms were predictive for later heart complaints. Conclusions: This study suggests that major depression is a predictor for heart complaints at the age of 40 and that the severity of depressive disorder in younger age has an effect on subsequent heart complaints. Follow-up data will help to elucidate whether these subjective heart complaints show any correlation with a later coronary heart disease
    Publication en relation: European Archives of Psychiatry and Clinical Neuroscience. - 2007/257/7/396-401
    Document hôte: European Archives of Psychiatry and Clinical Neuroscience
    Identifiant: 10.1007/s00406-007-0747-x (DOI)

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    Is the association of alcohol use disorders with major depressive disorder a consequence of undiagnosed bipolar-II disorder?

    Angst, Jules, Gamma, Alex, Endrass, Jérôme, Rössler, Wulf, Ajdacic-Gross, Valdeta, Eich, Dominique, Herrell, Richard, Merikangas, Kathleen Ries
    European Archives of Psychiatry and Clinical Neuroscience, 2006, Vol.256(7), pp.452-457 [Revue évaluée par les pairs]

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    Is the association of alcohol use disorders with major depressive disorder a consequence of undiagnosed bipolar-II disorder?

    Angst, Jules
    Gamma, Alex, Endrass, Jérôme, Rössler, Wulf, Ajdacic-Gross, Valdeta, Eich, Dominique, Herrell, Richard, Merikangas, Kathleen Ries
    European Archives of Psychiatry and Clinical Neuroscience. - 2006/256/7/452-457
    Disponible
    Plus…
    Titre: Is the association of alcohol use disorders with major depressive disorder a consequence of undiagnosed bipolar-II disorder?
    Auteur: Angst, Jules
    Contributeur: Gamma, Alex; Endrass, Jérôme; Rössler, Wulf; Ajdacic-Gross, Valdeta; Eich, Dominique; Herrell, Richard; Merikangas, Kathleen Ries
    Sujet: alcohol use disorders - alcohol abuse - alcohol dependence - bipolar II disorder - major depression - comorbidity
    Description: Background: There is emerging evidence that there is a spectrum of expression of bipolar disorder. This paper uses the well-established patterns of comorbidity of mood and alcohol use disorder to test the hypothesis that application of an expanded concept of bipolar-II (BP-II) disorder might largely explain the association of alcohol use disorders (AUD) with major depressive disorder (MDD). Method: Data from the Zurich study, a community cohort assessed over 6 waves from ages 20/21 to 40/41, were used to investigate the comorbidity between mood disorders and AUD. Systematic diagnostic criteria were used for alcohol abuse, alcohol dependence, MDD, and BP-II. In addition to DSM criteria, two increasingly broad definitions of BP-II were employed. Results: There was substantially greater comorbidity for the BP-II compared to major depression and for alcohol dependence compared to alcohol abuse. The broadest concept of BP-II explained two thirds of all cases of comorbidity of AUD with major depressive episodes (MDE). In fact, the broader the definition of BP-II applied, the smaller was the association of AUD with MDD, up to non-significance. In the majority of cases, the onset of bipolar manifestations preceded that of drinking problems by at least 5 years. Conclusions: The findings that the comorbidity of mood disorders with AUD was primarily attributable to BP-II rather than MDD and that bipolar symptoms usually preceded alcohol problems may encourage new approaches to prevention and treatment of AUD
    Publication en relation: European Archives of Psychiatry and Clinical Neuroscience. - 2006/256/7/452-457
    Document hôte: European Archives of Psychiatry and Clinical Neuroscience
    Identifiant: 10.1007/s00406-006-0673-3 (DOI)