Cette recherche s'applique uniquement aux ressources en bibliothèque.
7 résultats
Trier par:
Ajouter à la liste:
    • Livre

    Le culte de Galnée

    Cotter, Nicolas, 1990-
    Paris : Publibook
    Recherche de la disponibilité
    Erreur de chargement
    Titre: Le culte de Galnée / Nicolas Cotter
    Auteur: Cotter, Nicolas, 1990-
    Editeur: Paris : Publibook
    Date: 2009
    Collation: 119 p. : ill. ; 23 cm
    Collection: Science-fiction
    Documents dans cette collection: Science-fiction
    Décrit dans: Journal de Sion, 2010,201 (Hervé Lochmatter) ; L'Agache, février 2010,p.11 (Hervé Lochmatter)
    Note: Roman de science-fiction
    Classification: vs-bvs-sys 09.01.01
    cdu-vsprat COTT
    Identifiant: 9782748350630 (ISBN)
    No RERO: R005418498

    • Article

    Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease

    Roche, Sarah L, Kutsyr, Oksana, Cuenca, Nicolás, Cotter, Thomas G
    Investigative ophthalmology & visual science, 01 July 2019, Vol.60(8), pp.3221-3235 [Revue évaluée par les pairs]
    MEDLINE/PubMed (U.S. National Library of Medicine)
    Titre: Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease
    Auteur: Roche, Sarah L; Kutsyr, Oksana; Cuenca, Nicolás; Cotter, Thomas G
    Sujet: Neuroprotection -- Drug Effects ; Norgestrel -- Pharmacology ; Progesterone -- Pharmacology ; Retinal Cone Photoreceptor Cells -- Drug Effects ; Retinitis Pigmentosa -- Drug Therapy
    Description: Retinitis pigmentosa (RP) refers to a group of inherited blinding retinal diseases, whereby the death of mutated rod photoreceptors is followed closely by the death of cone photoreceptors. Cone cell death can be hugely debilitating as color/daytime vision becomes impaired. Thus, treatments that are effective against cone cell death are urgently needed. Our research has been working toward development of a neuroprotective treatment for RP. We have previously demonstrated significant neuroprotective properties of norgestrel, a progesterone analogue, in the mouse retina. The current study further investigates the potential of norgestrel as a treatment for RP, with a focus on long-term preservation of cone photoreceptors. Using the well-established rd10 mouse model of RP, we administered a norgestrel-supplemented diet at postnatal day (P)30, following widespread loss of rod photoreceptors and at the outset of cone degeneration. We subsequently assessed cone cell morphology and retinal function at P50, P60, and P80, using immunohistochemistry, electroretinograph recordings, and optomotor testing. While cone cell degeneration was widespread in the untreated rd10 retina, we observed profound preservation of cone photoreceptor morphology in the norgestrel-treated mice for at least 50 days, out to P80. This was demonstrated by up to 28-fold more cone arrestin-positive photoreceptors. This protection transpired to functional preservation at all ages. This work presents norgestrel as an incredibly promising long-term neuroprotective compound for the treatment of RP. Crucially, norgestrel could be used in the mid-late stages of the disease to protect remaining cone cells and help preserve color/daytime vision.
    Fait partie de: Investigative ophthalmology & visual science, 01 July 2019, Vol.60(8), pp.3221-3235
    Identifiant: 1552-5783 (E-ISSN); 31335948 Version (PMID); 10.1167/iovs.19-27246 (DOI)

    • Plusieurs versions

    Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling

    Roche, Sarah L, Wyse-Jackson, Alice C, Gómez-Vicente, Violeta, Lax, Pedro, Ruiz-Lopez, Ana M, Byrne, Ashleigh M, Cuenca, Nicolás, Cotter, Thomas G
    PLoS ONE, 2016, Vol.11(11) [Revue évaluée par les pairs]

    • Plusieurs versions

    Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway

    Fernando, Ruani N, Cotter, Laurent, Perrin-Tricaud, Claire, Berthelot, Jade, Bartolami, Sylvain, Pereira, Jorge A, González, Sergio, Suter, Ueli, Tricaud, Nicolas
    Nature communications, 20 July 2016, Vol.7(1), p.12186 [Revue évaluée par les pairs]

    • Article

    Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves

    Ozçelik, Murat, Cotter, Laurent, Jacob, Claire, Pereira, Jorge A, Relvas, João B, Suter, Ueli, Tricaud, Nicolas
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 17 March 2010, Vol.30(11), pp.4120-31 [Revue évaluée par les pairs]
    MEDLINE/PubMed (U.S. National Library of Medicine)
    Titre: Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves
    Auteur: Ozçelik, Murat; Cotter, Laurent; Jacob, Claire; Pereira, Jorge A; Relvas, João B; Suter, Ueli; Tricaud, Nicolas
    Sujet: Cell Polarity -- Physiology ; Epithelial Cells -- Enzymology ; Membrane Proteins -- Physiology ; Myelin Sheath -- Enzymology ; Nucleoside-Phosphate Kinase -- Physiology ; Peripheral Nerves -- Enzymology
    Description: Diameter, organization, and length of the myelin sheath are important determinants of the nerve conduction velocity, but the basic molecular mechanisms that control these parameters are only partially understood. Cell polarization is an essential feature of differentiated cells, and relies on a set of evolutionarily conserved cell polarity proteins. We investigated the molecular nature of myelin sheath polarization in connection with the functional role of the cell polarity protein pals1 (Protein Associated with Lin Seven 1) during peripheral nerve myelin sheath extension. We found that, in regard to epithelial polarity, the Schwann cell outer abaxonal domain represents a basolateral-like domain, while the inner adaxonal domain and Schmidt-Lanterman incisures form an apical-like domain. Silencing of pals1 in myelinating Schwann cells in vivo resulted in a severe reduction of myelin sheath thickness and length. Except for some infoldings, the structure of compact myelin was not fundamentally...
    Fait partie de: The Journal of neuroscience : the official journal of the Society for Neuroscience, 17 March 2010, Vol.30(11), pp.4120-31
    Identifiant: 1529-2401 (E-ISSN); 20237282 Version (PMID); 10.1523/JNEUROSCI.5185-09.2010 (DOI)

    • Plusieurs versions

    The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis

    Abbott, T. E. F, Ahmad, T, Phull, M. K, Fowler, A. J, Hewson, R, Biccard, B. M, Chew, M. S, Gillies, M, Pearse, R. M, Pearse, Rupert M, Beattie, Scott, Clavien, Pierre-Alain, Demartines, Nicolas, Fleisher, Lee A, Grocott, Mike, Haddow, James, Hoeft, Andreas, Holt, Peter, Moreno, Rui, Pritchard, Naomi, Rhodes, Andrew, Wijeysundera, Duminda, Wilson, Matt, Ahmed, Tahania, Everingham, Kirsty, Hewson, Russell, Januszewska, Marta, Phull, Mandeep-Kaur, Halliwell, Richard, Shulman, Mark, Myles, Paul, Schmid, Werner, Hiesmayr, Michael, Wouters, Patrick, de Hert, Stefan, Lobo, Suzana, Fang, Xiangming, Rasmussen, Lars, Futier, Emmanuel, Biais, Matthieu, Venara, Aurélien, Slim, Karem, Sander, Michael, Koulenti, Despoina, Arvaniti, Kostoula, Chan, Mathew, Kulkarni, Atul, Chandra, Susilo, Tantri, Aida, Geddoa, Emad, Abbas, Muntadhar, Della Rocca, Giorgio, Sivasakthi, Datin, Mansor, Marzida, Luna, Pastor, Bouwman, Arthur, Buhre, Wolfgang, Beavis, Vanessa, Campbell, Douglas, Short, Tim, Osinaike, Tunde, Matos, Ricardo, Grigoras, Ioana, Kirov, Mikhail, Protsenko, Denis, Biccard, Bruce, Aldecoa, Cesar, Chew, Michelle, Hofer, Christoph, Hubner, Martin, Ditai, James, Szakmany, Tamas, Fleisher, Lee, Ferguson, Marissa, Macmahon, Michael, Cherian, Ritchie, Currow, Helen, Kanathiban, Kathirgamanathan, Gillespie, David, Pathmanathan, Edward, Phillips, Katherine, Reynolds, Jenifer, Rowley, Joanne, Douglas, Jeanene, Kerridge, Ross, Garg, Sameer, Bennett, Michael, Jain, Megha, Alcock, David, Terblanche, Nico, Cotter, Rochelle, Leslie, Kate, Stewart, Marcelle, Zingerle, Nicolette, Clyde, Antony, Hambidge, Oliver, Rehak, Adam, Cotterell, Sharon, Huynh, Wilson Binh Quan, Mcculloch, Timothy, Ben-Menachem, Erez, Egan, Thomas, Cope, Jennifer, Fellinger, Paul, Haisjackl, Markus, Haselberger, Simone, Holaubek, Caroline, Lichtenegger, Paul, Scherz, Florian, Hoffer, Franz, Cakova, Veronika, Eichwalder, Andreas, Fischbach, Norbert, Klug, Reinhold, Schneider, Elisabeth, Vesely, Martin, Wickenhauser, Reinhart, Grubmueller, Karl Gernot, Leitgeb, Marion, Lang, Friedrich, Toro, Nancy, Bauer, Marlene, Laengle, Friedrich, Haberl, Claudia, Mayrhofer, Thomas, Trybus, Christoph, Buerkle, Christian, Forstner, Karin, Germann, Reinhard, Rinoesl, Harald, Schindler, Elke, Trampitsch, Ernst, Bogner, Gerhard, Dankl, Daniel, Duenser, Martin, Fritsch, Gerhard, Gradwohl-Matis, Ilse, Hartmann, Andreas, Hoelzenbein, Thomas, Jaeger, Tarkan, Landauer, Franz, Lindl, Gregor, Lux, Michael, Steindl, Johannes, Stundner, Ottokar, Szabo, Christian, Bidgoli, Jawad, Verdoodt, Hans, Forget, Patrice, Kahn, David, Lois, Fernande, Momeni, Mona, Prégardien, Caroline, Pospiech, Audrey, Steyaert, Arnaud, Veevaete, Laurent, De Kegel, Dirk, De Jongh, Karen, Foubert, Luc, Smitz, Carine, Vercauteren, Marcel, Poelaert, Jan, Van Mossevelde, Veerle, Abeloos, Jacques, Bouchez, Stefaan, Coppens, Marc, De Baerdemaeker, Luc, Deblaere, Isabel, De Bruyne, Ann, Fonck, Kristine, Heyse, Bjorn, Jacobs, Tom, Lapage, Koen, Moerman, Anneliese, Neckebroek, Martine, Parashchanka, Aliaksandra, Roels, Nathalie, Van Den Eynde, Nancy, Vandenheuvel, Michael, Limmen, Jurgenvan, Vanluchene, Ann, Vanpeteghem, Caroline, Wyffels, Piet, Huygens, Christel, Vandenbempt, Punitha, Van de Velde, Marc, Dylst, Dimitri, Janssen, Bruno, Schreurs, Evelien, Aleixo, Fábia Berganton, Candido, Keulle, Batista, Hugo Dias, Guimarães, Mario, Guizeline, Jaqueline, Hoffmann, João, Lobo, Francisco Ricardo Marques, Nascimento, Vinícius, Nishiyama, Katia, Pazetto, Lucas, Souza, Daniela, Rodrigues, Rodrigo Souza, Vilela Dos Santos, Ana Maria, Jardim, Jaquelline, Sá Malbouisson, Luiz Marcelo, Silva, Joao, Nascimento Junior, Paulo Do, Baio, Thalissa Hermínia, Pereira de Castro, Gabriel Isaac, Watanabe Oliveira, Henri Roger, Amendola, Cristina Prata, Cardoso, Gutemberg, Ortega, Daniela, Brotto, Ana Flavia, De Oliveira, Mirella Cristine, Réa-Neto, Álvaro, Dias, Fernando, Travi, Maria Eduarda, Zerman, Luiza, Azambuja, Pedro, Knibel, Marcos Freitas, Martins, Antonio, Almeida, William, Neto, Calim Neder, Tardelli, Maria Angela, Caser, Eliana, Machado, Marcio, Aguzzoli, Crisitiano, Baldisserotto, Sérgio, Tabajara, Fernanda Beck, Bettega, Fernanda, Rodrigues Júnior, La Hore Correa, de Gasperi, Julia, Faina, Lais, Nolasco, Marcos Farias, Ferreira Da Costa Fischer, Bruna, Fosch de Campos Ferreira, Mariana, Hartmann, Cristina, Kliemann, Marta, Hubert Ribeiro, Gustavo Luis, Fraga, Julia Merladete, Netto, Thiago Motta, Pozza, Laura Valduga, Wendling, Paulo Rafael, Azevedo, Caroline, Garcia, Juliana, Lopes, Marcel, Maia, Bernardo, Maselli, Paula, Melo, Ralph, Mendes, Weslley
    British Journal of Anaesthesia, 01 January 2018, Vol.120(1) [Revue évaluée par les pairs]

    • Plusieurs versions

    Improved cardiac and venous pressures during hospital stay in patients with acute heart failure: an echocardiography and biomarkers study

    Akiyama, Eiichi, Cinotti, Raphaël, Čerlinskaitė, Kamilė, Van Aelst, Lucas N L, Arrigo, Mattia, Placido, Rui, Chouihed, Tahar, Girerd, Nicolas, Zannad, Faiez, Rossignol, Patrick, Badoz, Marc, Launay, Jean-Marie, Gayat, Etienne, Cohen-Solal, Alain, Lam, Carolyn S P, Testani
    ESC heart failure, June 2020, Vol.7(3), pp.996-1006 [Revue évaluée par les pairs]